Dynamics of Superparamagnetic Iron Oxide Nanoparticles with Various Polymeric Coatings

Strączek, Tomasz; Fiejdasz, Sylwia; Rybicki, Damian; Goc, Kamil; Przewoźnik, J.; Mazur, Weronika; Nowakowska, Maria; Zapotoczny, Szczepan; Rumian, Stanisław; Kapusta, Cz.

doi:10.3390/ma12111793

Cited by 17 publications

(11 citation statements)

References 59 publications

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“…SPION can be obtained by various methods of synthesis such as sol-gel, coprecipitation, thermal decomposition, hydrothermal method, etc. [ 5 , 13 ]. Co-precipitation synthesis is among the most used because it is a cheap and efficient method that allows the easy obtaining of superparamagnetic iron oxide nanoparticles [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

“…[ 5 , 13 ]. Co-precipitation synthesis is among the most used because it is a cheap and efficient method that allows the easy obtaining of superparamagnetic iron oxide nanoparticles [ 13 ]. In general, to prevent the agglomeration of nanoparticles and to improve their colloidal stability and biological properties, they are incorporated into polymers (chitosan, dextran, poly(vinyl alcohol)—PVA, gelatin, polyvinylpyrrolidone (PVP), etc.)…”

Section: Introductionmentioning

confidence: 99%

“…In general, to prevent the agglomeration of nanoparticles and to improve their colloidal stability and biological properties, they are incorporated into polymers (chitosan, dextran, poly(vinyl alcohol)—PVA, gelatin, polyvinylpyrrolidone (PVP), etc.) [ 6 , 13 , 14 , 15 , 16 ]. Dextran, (H(C 6 H 10 O 5 )xOH), is one of the most widely used natural polysaccharides used as a coating for SPION [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

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Preparation and Characterization of Dextran Coated Iron Oxide Nanoparticles Thin Layers

et al. 2021

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In the present study, we report the synthesis of a dextran coated iron oxide nanoparticles (DIO-NPs) thin layer on glass substrate by an adapted method. The surface morphology of the obtained samples was analyzed by Scanning Electron Microscopy (SEM), Atomic Force Microscopy (AFM), optical, and metallographic microscopies. In addition, the distribution of the chemical elements into the DIO-NPs thin layer was analyzed by Glow Discharge Optical Emission Spectrometry (GDOES). Furthermore, the chemical bonds formed between the dextran and iron oxide nanoparticles was investigated by Fourier Transform Infrared Spectroscopy (FTIR). Additionally, the HepG2 viability incubated with the DIO-NPs layers was evaluated at different time intervals using MTT (3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. The goal of this study was to obtain a DIO-NPs thin layer which could be used as a coating for medical devices such as microfluidic channel, microchips, and catheter. The results of the surface morphology investigations conducted on DIO-NPs thin layer suggests the presence of a continuous and homogeneous layer. In addition, the GDOES results indicate the presence of C, H, Fe, and O signal intensities characteristic to the DIO-NPs layers. The presence in the IR spectra of the Fe-CO metal carbonyl vibration bonds prove that the linkage between iron oxide nanoparticles and dextran take place through carbon–oxygen bonds. The cytotoxicity assays highlighted that HepG2 cells morphology did not show any noticeable modifications after being incubated with DIO-NPs layers. In addition, the MTT assay suggested that the DIO-NPs layers did not present any toxic effects towards HEpG2 cells.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Preparation and Characterization of Dextran Coated Iron Oxide Nanoparticles Thin Layers

et al. 2021

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“…The resulting SPION/CCh nanoparticles had a high positive charge in a wide range of pH and thus were colloidally stable; they also showed excellent magnetic properties. 22 , 23 These SPION were then further functionalized to obtain MRI contrasts specifically targeting endothelium in early stages of inflammation 24 and a new system for magnetic hyperthermia. 25 …”

Section: Introductionmentioning

confidence: 99%

Specific Binding of Novel SPION-Based System Bearing Anti-N-Cadherin Antibodies to Prostate Tumor Cells

Karnas¹,

Strączek²,

Kapusta³

et al. 2021

IJN

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Purpose Epithelial–mesenchymal (EMT) transition plays an important role in metastasis and is accompanied by an upregulation of N-cadherin expression. A new nanoparticulate system (SPION/CCh/N-cad) based on superparamagnetic iron oxide nanoparticles, stabilized with a cationic derivative of chitosan and surface-modified with anti-N-cadherin antibody, was synthetized for the effective capture of N-cadherin expressing circulating tumor cells (CTC). Methods The morphology, physicochemical, and magnetic properties of the system were evaluated using dynamic light scattering (DLS), fluorescence spectroscopy, Mössbauer spectroscopy, magnetometry, and fluorescence spectroscopy. Atomic force microscopy (AFM), confocal microscopy and flow cytometry were used to study the interaction of our nanoparticulate system with N-cadherin expressed in prostate cancer cell lines (PC-3 and DU 145). A purpose-built cuvette was used in the cancer cell capture experiments. Results The obtained nanoparticles were a spherical, stable colloid, and exhibited excellent magnetic properties. Biological experiments confirmed that the novel SPION/CCh/N-cad system interacts specifically with N-cadherin present on the cell surface. Preliminary studies on the magnetic capture of PC-3 cells using the obtained nanoparticles were successful. Incubation times as short as 1 minute were sufficient for the synthesized system to effectively bind to the PC-3 cells. Conclusion Results obtained for our system suggest a possibility of using it to capture CTC in the flow conditions.

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“…Their limited toxicity, together with commonly applied biocompatible coatings, allows meeting the respective requirements concerning the adequate dose of particles. Furthermore, biomedical applications require high magnetization values and sizes typically smaller than 100 nm with a narrow distribution, which is possible to achieve with iron oxide nanoparticles [12][13][14][15][16]. An important aspect is also the use of an appropriate biocompatible coating; hydrophilic coatings are commonly based on polysaccharides and polypeptides, while hydrophobic coatings are commonly based on surfactants [16][17][18].…”

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Hydrophobically Coated Superparamagnetic Iron Oxides Nanoparticles Incorporated into Polymer-Based Nanocapsules Dispersed in Water

et al. 2020

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This paper reports the characterization of iron oxide magnetic nanoparticles obtained via the thermal decomposition of an organometallic precursor, which were then loaded into nanocapsules prepared via the emulsification process in the presence of an amphiphilic derivative of chitosan. The applied synthetic method led to the formation of a hydrophobic layer on the surface of nanoparticles that enabled their loading in the hydrophobic liquid inside of the polymer-based capsules. The average diameter of nanoparticles was determined to be equal to 15 nm, and they were thoroughly characterized using X-ray diffraction (XRD), magnetometry, and Mössbauer spectroscopy. A core-shell structure consisting of a wüstite core and maghemite-like shell was revealed, resulting in an exchange bias effect and a considerable magnetocrystalline anisotropy at low temperatures and a superparamagnetic behavior at room temperature. Importantly, superparamagnetic behavior was observed for the aqueous dispersion of the nanocapsules loaded with the superparamagnetic nanoparticles, and the dispersion was shown to be very stable (at least 48 weeks). The results were analyzed and discussed with respect to the potential future applications of these nanoparticles and nanocapsules based on biopolymers as platforms designed for the magnetically navigated transport of encapsulated hydrophobic substances.

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Dynamics of Superparamagnetic Iron Oxide Nanoparticles with Various Polymeric Coatings

Cited by 17 publications

References 59 publications

Preparation and Characterization of Dextran Coated Iron Oxide Nanoparticles Thin Layers

Preparation and Characterization of Dextran Coated Iron Oxide Nanoparticles Thin Layers

Specific Binding of Novel SPION-Based System Bearing Anti-N-Cadherin Antibodies to Prostate Tumor Cells

Hydrophobically Coated Superparamagnetic Iron Oxides Nanoparticles Incorporated into Polymer-Based Nanocapsules Dispersed in Water

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