Dynamics of Proinflammatory Cytokine Levels and Their Role in the Development of Local and Systemic Effects during Progressing Cervical Cancer

Генинг, Т. П.; Антонеева, И. И.; Абакумова, Т. В.; Peskov, A.B.; Сидоренко, Е. Г.; Генинг, С. О.; Долгова, Д Р

doi:10.1007/s10517-014-2665-z

Cited by 5 publications

(6 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In recent years, authors say that marking IL-6 concentrations before treatment can influence the estimation of DFS and OS. They place stress on the important role of proinflammatory cytokines, IL-6 included, in the progression of cervical cancer, particularly in early stages of development [ 5 , 27 ]. Our studies confirmed those reports.…”

Section: Discussionmentioning

confidence: 99%

The assessment of the prognostic value of tumor markers and cytokines as SCCAg, CYFRA 21.1, IL-6, VEGF and sTNF receptors in patients with squamous cell cervical cancer, particularly with early stage of the disease

et al. 2015

View full text Add to dashboard Cite

The aim of this study is to determine the prognostic value of tumor markers, as squamous cell carcinoma antigen (SCCAg) and cytokeratin-19 fragment (CYFRA 21.1) and interleukin 6 (IL-6), vascular endothelial growth factor (VEGF), soluble tumor necrosis factor receptor I (sTNF RI), and sTNF RII in patients with squamous cell carcinoma of the cervix. The subjects of analysis were 138 patients with stage I–IVA according to the International Federation of Gynecology and Obstetrics (FIGO) classification. The collected research material comes from one oncology center. During the 10 years of follow-up, 56 relapses and 53 deaths were observed, and recurrent disease in early stage was confirmed in 45 % of patients. The pretreatment serum levels of SCCAg and CYFRA 21.1, and cytokines IL-6, VEGF, sTNF RI, and sTNF RII were determined in all patients. The probability of disease-free survival (DFS) and overall survival (OS) was evaluated using the log-rank test and the Cox regression model. Based on the ROC curve analysis for patients with recurrence, the largest area under the curve was demonstrated for SCCAg and IL-6 and for patients who died, for SCCAg and VEGF. Cox analysis demonstrated that independent prognostic factor for DFS was only SCCAg and for OS cytokine IL-6 and SCCAg, but in patients with early stage the prognostic value for DFS was VEGF, whereas IL-6 and CYFRA 21.1 for OS. Serum level of VEGF, CYFRA 21.1 and IL-6 before treatment in patients with early stage cervical cancer appears to be an important prognostic factor.

show abstract

Section: Discussionmentioning

confidence: 99%

The assessment of the prognostic value of tumor markers and cytokines as SCCAg, CYFRA 21.1, IL-6, VEGF and sTNF receptors in patients with squamous cell cervical cancer, particularly with early stage of the disease

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Studies have found a correlation between HPV infection and serum IL-10 levels in local tissue [ 19 ]. In fact, two studies found an increase in serum IL-10 associated with various stages of cervical cancer [ 20 , 21 ]. Moreover, immature stromal dendritic cells expressing IL-10 are more numerous in cervical cancer than in normal cervix and cervical intraepithelial neoplasia [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Identification of a serum-induced transcriptional signature associated with metastatic cervical cancer

Palatnik

Kendziorski

et al. 2017

PLoS ONE

View full text Add to dashboard Cite

ObjectiveTumor cells that escape local tissue control can convert inflammatory cells from tumor suppressors to tumor promoters. Moreover, soluble immune-modulating factors secreted from the tumor environment can be difficult to identify in patient serum due to their low abundance. We used an alternative strategy to infer a metastatic signature induced by sera of cervical cancer patients.MethodsSera from patients with local and metastatic cervical cancer were used to induce a disease-specific transcriptional signature in cultured, healthy peripheral blood mononuclear cells (PBMCs). An empirical Bayesian method, EBarrays, was used to identify differentially expressed (DE) genes with a target false discovery rate of <5%. Ingenuity Pathway Analysis (IPA) software was used to detect the top molecular and cellular functions associated with the DE genes. IPA and in silco analysis was used to pinpoint candidate upstream regulators, including cancer-related microRNAs (miRNAs).ResultsWe identified enriched pathways in the metastatic cervical group related to immune surveillance functions, such as downregulation of engulfment, accumulation, and phagocytosis of hematopoietic cells. The predicted top upstream genes were IL-10 and immunoglobulins. In silco analysis identified miRNAs predicted to drive the transcriptional signature. Two of the 4 miRNAs (miR-23a-3p and miR-944) were validated in a cohort of women with local and metastatic cervical cancer.ConclusionsThis study supports the use of a cell-based assay that uses PBMC “reporters” to predict biologically relevant factors in patient serum. Further, disease-specific transcriptional signatures induced by patient sera have the potential to differentiate patients with local versus metastatic disease.

show abstract

“…Followed by production of chemokines, vascular growth factor and tumor growth factor provide favorable immune microenvironment for the survival of tumor cells and progression of lesion. Additionally, the circulating levels of TNF-α were increased with the increased clinical stage progress, and expression levels of KI-67, Bcl-2 and p53 in stage Iβ-IIa of cervical carcinoma were positively correlated with the levels of TNF-α [17].…”

Section: Discussionmentioning

confidence: 94%

Cytokines profiles in cervical mucosa in patients with cervical high-risk human papillomavirus infection

Long

Song

2021

J Infect Dev Ctries

View full text Add to dashboard Cite

Introduction: The purpose of this study was to detect the expression of local cytokines in cervical mucosa between patients with transient and persistent HR-HPV infection with or without CIN. Methodology: A total of 150 patients who were diagnosed as HR-HPV infection in Tianjin Central Hospital of Obstetrics and Gynecology from January 2016 to December 2016 were included in this study. The expression levels of 9 cytokines in 150 patients with HR-HPV infection, including interleukin (IL)-1β, IL-4, IL-6, IL-8, IL-10, IL-12, IL-12p70, IL-21, interferon (IFN)-γ and tumor necrosis factor (TNF)-α, were simultaneously measured by using a multiplex immunoassay. Moreover, HR-HPV genotype was performed by using pyrosequencing. The association between cytokines and HPV genotype was also investigated. Results: There was a statistically significant difference in IL-1β level between patients with HPV transient infection and HPV persistent infection (p = 0.041). There were statistically significant differences in the levels of IL-1β, IL-10, IL-21 and TNF-α between patients with low grade squamous intraepithelial lesion (LSIL) and high grade squamous intraepithelial lesion (HSIL) (p = 0.011, p = 0.008, p = 0.046 and p = 0.019, respectively). Conclusions: Pro-inflammatory cytokines, IL-1β and TNF-α, and Th2 type cytokines, IL-10 and IL-21, became stronger in cervical mucosa with the progression of CIN. IL-1β may be advantageous for HR-HPV persistent infection.

show abstract

Dynamics of Proinflammatory Cytokine Levels and Their Role in the Development of Local and Systemic Effects during Progressing Cervical Cancer

Cited by 5 publications

References 6 publications

The assessment of the prognostic value of tumor markers and cytokines as SCCAg, CYFRA 21.1, IL-6, VEGF and sTNF receptors in patients with squamous cell cervical cancer, particularly with early stage of the disease

The assessment of the prognostic value of tumor markers and cytokines as SCCAg, CYFRA 21.1, IL-6, VEGF and sTNF receptors in patients with squamous cell cervical cancer, particularly with early stage of the disease

Identification of a serum-induced transcriptional signature associated with metastatic cervical cancer

Cytokines profiles in cervical mucosa in patients with cervical high-risk human papillomavirus infection

Contact Info

Product

Resources

About