Dynamics and plasticity of stem cells in the regenerating human colonic epithelium
Koen C. Oost,
Maurice Kahnwald,
Silvia Barbiero
et al.
Abstract:SummaryThe human intestinal epithelium is a tissue with rapid turnover. Its complex regenerative process and differentiation trajectories have been challenging to study due to its inaccessibility and lack of temporal sampling. To this end, we developed a workflow to culture adult stem cell-derived human intestinal organoids from single cells to maturation. Extensive characterization of our model system indicated a transient regenerative response, followed by differentiation into all mature cell lineages. This … Show more
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