Dynamic swelling behavior of pH‐sensitive anionic hydrogels used for protein delivery

Kim, Bumsang; Flamme, Kristen La; Peppas, Nicholas A.

doi:10.1002/app.12337

Cited by 253 publications

(142 citation statements)

References 27 publications

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“…It was found that the solvent transport mechanism became non-Fickian (more relaxation-controlled) as gel ionisation became prominent. As discussed earlier by Peppas et al [29,31,32], the dynamic swelling behaviour of hydrogels is dependent on the relative contribution of penetrant diffusion and polymer relaxation. In the ionic hydrogels the ionisation of functional groups may control the water diffusion process, thus affecting the relative magnitude of diffusion and relaxation times [29,42].…”

Section: Case III (Or Anomalous Diffusion Non-fickian Diffusion)mentioning

confidence: 80%

“…The mechanism of water transport in a swelling hydrogel is greatly affected by many factors, such as equilibrium water content, chemical composition of the hydrogel, swelling rate, etc. [30,32]. In general, three models are used to describe transport phenomena into polymer networks [33][34][35][36][37].…”

Section: Swelling Kinetics Of Hydrogel Membranesmentioning

confidence: 99%

“…from relaxation-controlled to diffusion-controlled. The effect of pH on the mechanism of water transport into ionic hydrogels was studied earlier by several researchers [32,[39][40][41]. It was found that the solvent transport mechanism became non-Fickian (more relaxation-controlled) as gel ionisation became prominent.…”

Section: Case III (Or Anomalous Diffusion Non-fickian Diffusion)mentioning

confidence: 99%

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pH-responsive hydrogel membranes based on modified chitosan: water transport and kinetics of swelling

2015

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pH-responsive membranes prepared by treating chitosan (Ch) with glutaraldehyde (GA) or with GA and sulfuric acid (SA) were studied. The structure and properties of the membranes were characterized by Fourier transform infrared (FTIR) spectroscopy, wide-angle X-ray diffraction (WAXD), scanning electron microscopy (SEM), atomic force microscopy (AFM), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) and elemental analysis. The effect of the cross-linking process both on the dynamic swelling behaviour of the hydrogel membranes and on the mechanism of water transport through those membranes was investigated in buffer solutions of different pH (1.2-9.5). The mechanism of water transport through the hydrogel chitosan membranes was affected by membrane composition and pH of the swelling medium. Non-cross-linked Ch membrane showed a non-Fickian swelling behaviour in the pH range 6.5-9.5. Chitosan membrane cross-linked with GA (Ch/GA) showed less-Fickian or Fickian swelling behaviour in all buffer solutions. In the case of chitosan membrane cross-linked with GA and SA (Ch/GA/SA), at low pH (lower than the pK a of the hydrogel) the water transport was controlled more by polymer relaxation than by penetrant diffusion. The experimental data clearly suggested that the swelling process in all buffer solutions obeyed second-order kinetics. Values of an apparent swelling rate constant for Ch/ GA and Ch/GA/SA membranes were of the same order of magnitude for acidic and neutral swelling media but they increased for alkaline solutions.

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Section: Case III (Or Anomalous Diffusion Non-fickian Diffusion)mentioning

confidence: 80%

Section: Swelling Kinetics Of Hydrogel Membranesmentioning

confidence: 99%

Section: Case III (Or Anomalous Diffusion Non-fickian Diffusion)mentioning

confidence: 99%

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pH-responsive hydrogel membranes based on modified chitosan: water transport and kinetics of swelling

2015

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“…Generally, the swelling processes of the gels are described from the kinetic point of view by the Peppas equation [28][29][30][31] (Equation (2)): (2) This equation allows to calculate the exponent n that indicates the water (or other species) diffusion mechanism (Fickian or non-Fickian) and the diffusion constant k. This equation is not applicable in our case, due to the complexity of the process and changing gel morphology. If we still try to apply this equation, we get very low n-values, which do not correspond to the diffusion mechanism.…”

Section: 7mentioning

confidence: 99%

Study of the PVA hydrogel behaviour in 1-butyl-3-methylimidazolium tetrafluoroborate ionic liquid

Paţachia¹,

Friedrich²,

Florea³

et al. 2011

Express Polym. Lett.

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Abstract. The present paper aims at studying the behaviour of the poly(vinyl alcohol) [PVA] cryogel in the presence of 1-butyl-3-methylimidazolium tetrafluoroborate ([BMIM] + [BF 4 ] -) aqueous solutions with various concentrations. The gravimetric method showed that the swollen PVA cryogels exhibit mechanically active behaviour. PVA cryogels showed shrinking in the presence of ionic liquid, (IL), and re-swelling in the presence of distilled water. The re-swelling is not completely reversible, due to the influence of the IL ions on the gel morphology. The Fourier transform infrared (FTIR) spectra have indicated no chemical interaction between the PVA and the studied IL, but highlighted the gel crystallinity change as a function of IL concentration, as well as changes in the bound water amount. Rheological analyses showed dominating plastifying effect of the cation at a lower IL concentration and dominating kosmotropic effect of the anion at a higher IL concentration. A phenomenological kinetic equation that takes into account both fluxes of matters, in and out of the gel, is proposed, explaining the alteration of the gel properties when it comes in contact with BMIMBF 4 solutions.

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“…Peppas group [32][33][34][35] studied the drug delivery from a polymeric film or matrix into solution and found it obeyed to the following equation:…”

Section: Resultsmentioning

confidence: 99%

Halophilic bacteria are able to decontaminate dichlorvos, a pesticide, from saline environments

et al. 2007

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Dichlorvos (DDVP) is an organophosphorous pesticide with a high degree of dangerous effect towards the environment. We have investigated the growth and susceptibility to DDVP of halophilic bacteria isolated from Romanian salt lakes. The growth of four strains was affected by DDVP, which may be correlated with the rate constant values of DDVP disappearance from the saline solutions. This is due not to a chemical degradation in solution but to the diffusion process and namely DDVP penetration into the cell cytoplasm by an "organic-osmolyte" mechanism. The permeability coefficient P was calculated.

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Dynamic swelling behavior of pH‐sensitive anionic hydrogels used for protein delivery

Cited by 253 publications

References 27 publications

pH-responsive hydrogel membranes based on modified chitosan: water transport and kinetics of swelling

pH-responsive hydrogel membranes based on modified chitosan: water transport and kinetics of swelling

Study of the PVA hydrogel behaviour in 1-butyl-3-methylimidazolium tetrafluoroborate ionic liquid

Halophilic bacteria are able to decontaminate dichlorvos, a pesticide, from saline environments

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