Dynamic states of cells adhering in shear flow: From slipping to rolling

Korn, Christian; Schwarz, Ulrich S.

doi:10.1103/physreve.77.041904

Cited by 76 publications

(127 citation statements)

References 71 publications

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“…In the context of the state space of descriptors of adhesion moieties, the forward binding rate between solvated cationic nanoparticles and a silica surface is fundamentally fast. Connecting to literature on receptor physics, it is known, for instance, that neutrophil rolling on the endothelium requires a fast forward binding constant 68,69,136 such as that seen with the cationic nanoparticles, but rolling also depends on the dissociation rate constant. The latter is not addressed here.…”

Section: Examples and Explanationsmentioning

confidence: 99%

“…Binding and unbinding rate constants comprise a "state space" in which different families of adhesion molecules reside and accomplish their function. 68,69 Additionally, the sensitivity of the binding rates to external forces 64,70 is implicated in some unusual behavior, for instance, catch-stick or catch-slip bonds, [71][72][73][74][75] and the shear threshold observed for L-selectin. [76][77][78][79] This quantitative focus on the interfacial reaction rate constants of immobilized adhesion molecules is a relatively recent development within the biophysics community, and it has yet to impact materials design.…”

Section: Introductionmentioning

confidence: 99%

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Beyond Molecular Recognition: Using a Repulsive Field to Tune Interfacial Valency and Binding Specificity between Adhesive Surfaces

et al. 2008

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Surface-bound biomolecular fragments enable "smart" materials to recognize cells and other particles in applications ranging from tissue engineering and medical diagnostics to colloidal and nanoparticle assembly. Such smart surfaces are, however, limited in their design to biomolecular selectivity. This feature article demonstrates, using a completely nonbiological model system, how specificity can be achieved for particle (and cell) binding, employing surface designs where immobilized nanoscale adhesion elements are entirely nonselective. Fundamental principles are illustrated by a model experimental system where 11 nm cationic nanoparticles on a planar negative silica surface interact with flowing negative silica microspheres having 1.0 and 0.5 µm diameters. In these systems, the interfacial valency, defined as the number of cross-bonds needed to capture flowing particles, is tunable through ionic strength, which alters the range of the background repulsion and therefore the effective binding strength of the adhesive elements themselves. At high ionic strengths where long-range electrostatic repulsions are screened, single surface-bound nanoparticles capture microspheres, defining the univalent regime. At low ionic strengths, competing repulsions weaken the effective nanoparticle adhesion so that multiple nanoparticles are needed for microparticle capture. This article discusses important features of the univalent regime and then illustrates how multivalency produces interfacial-scale selectivity. The arguments are then generalized, providing a possible explanation for highly specific cell binding in nature, despite the degeneracy of adhesion molecules and cell types. The mechanism for the valency-related selectivity is further developed in the context of selective flocculation in the colloidal literature. Finally, results for multivalent binding are contrasted with the current thinking for interfacial design and the presentation of adhesion moieties on engineered surfaces.

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Section: Examples and Explanationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Beyond Molecular Recognition: Using a Repulsive Field to Tune Interfacial Valency and Binding Specificity between Adhesive Surfaces

et al. 2008

View full text Add to dashboard Cite

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“…Similar models with simple two-state kinetics have proven useful in a number of studies since it is relatively straightforward to include the force-dependent bond stability in a heuristic manner so that either slip or catch bond behavior is obtained [17][18][19][20][21] We present adsorption state diagrams as a function of shear rate, the surface-monomer bond dissociation and association rates and an effective catch bond parameter that describes the continuous change from slip to catch bond behavior. The adsorption transition displays shearinduced adsorption only for rather low dissociation and association rate and only for bonds that show neither pronounced slip nor catch bond behavior.…”

Section: Introductionmentioning

confidence: 99%

Shear-enhanced adsorption of a homopolymeric globule mediated by surface catch bonds

Radtke

Netz

2015

Eur. Phys. J. E

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Abstract. The adsorption of a single collapsed homopolymer onto a planar smooth surface in shear flow is investigated by means of Brownian hydrodynamics simulation. While cohesive intra-polymer forces are modeled by Lennard-Jones potentials, surface-monomer interactions are described by stochastic bonds whose two-state kinetics is characterized by three parameters: bond formation rate, bond dissociation rate and an effective catch bond parameter that describes how the force acting on a surface-monomer bond influences the dissociation rate. We construct adsorption state diagrams as a function of shear rate and all three surface-monomer bond parameters. We find shear-induced adsorption in a small range of parameters for low dissociation and association rates and only when the surface-monomer bond is near the transition between slip and catch bond behavior. By mapping on a simple surface-monomer interaction model with conservative pair potentials we try to estimate the conservative potential parameters necessary to observe shear-induced surface adsorption phenomena.

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“…As most technological and biological applications involve dissipation, there is general interest in understanding nonequilibrium aspects such as the adsorption of macromolecules in shear flow [2][3][4]. The present study is motivated by recent investigations [5] on the von Willebrand factor, a blood protein involved in hemostasis [6].…”

Section: Introductionmentioning

confidence: 99%

Shear-induced dynamics of polymeric globules at adsorbing homogeneous and inhomogeneous surfaces

Radtke

Netz

2014

Eur. Phys. J. E

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Abstract. The dynamics and adsorption behavior of a single collapsed homopolymer on a surface in shear flow is investigated by means of Brownian hydrodynamics simulations. We study different homogeneous and inhomogeneous surface models and determine dynamic state diagrams as a function of the cohesive strength, the adhesive strength, and the shear rate. We find distinct dynamical adsorbed states that are classified into rolling and slipping states, globular and coil-like states, as well as isotropic and prolate states. We identify two different cyclic processes based on trajectories of the polymer stretching and the polymer separation from the surface. For adsorption on an inhomogeneous surface consisting of discrete binding sites, we observe stick-roll motion for highly corrugated surface potentials. Although the resulting high surface friction leads to low drift velocities and reduced hydrodynamic lift forces on such inhomogeneous surfaces, a shear-induced adsorption is not found in the presence of full hydrodynamic interactions. A hydrodynamically stagnant surface model is introduced for which shear-induced adsorption is observed in the absence of hydrodynamic interactions.

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Dynamic states of cells adhering in shear flow: From slipping to rolling

Cited by 76 publications

References 71 publications

Beyond Molecular Recognition: Using a Repulsive Field to Tune Interfacial Valency and Binding Specificity between Adhesive Surfaces

Beyond Molecular Recognition: Using a Repulsive Field to Tune Interfacial Valency and Binding Specificity between Adhesive Surfaces

Shear-enhanced adsorption of a homopolymeric globule mediated by surface catch bonds

Shear-induced dynamics of polymeric globules at adsorbing homogeneous and inhomogeneous surfaces

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