Dynamic reorganization of the cortico-basal ganglia-thalamo-cortical network during task learning

Sych, Yaroslav; Fomins, Aleksejs; Novelli, Leonardo; Helmchen, Fritjof

doi:10.1016/j.celrep.2022.111394

Cited by 6 publications

(3 citation statements)

References 85 publications

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“…Next we used multi-fiber photometry 45 , 46 to test whether our approach would permit the optical detection and comparison of tonic DA levels across different brain regions within the same animal. Mice were implanted with 12 fiber-arrays (3 fibers targeting subregions of PFC, 4 fibers targeting NAc and 4 fibers targeting caudate putamen CPu/DS).…”

Section: Resultsmentioning

confidence: 99%

A chemogenetic approach for dopamine imaging with tunable sensitivity

Labouesse,

Wilhelm,

Kagiampaki

et al. 2024

Nat Commun

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Genetically-encoded dopamine (DA) sensors enable high-resolution imaging of DA release, but their ability to detect a wide range of extracellular DA levels, especially tonic versus phasic DA release, is limited by their intrinsic affinity. Here we show that a human-selective dopamine receptor positive allosteric modulator (PAM) can be used to boost sensor affinity on-demand. The PAM enhances DA detection sensitivity across experimental preparations (in vitro, ex vivo and in vivo) via one-photon or two-photon imaging. In vivo photometry-based detection of optogenetically-evoked DA release revealed that DETQ administration produces a stable 31 minutes window of potentiation without effects on animal behavior. The use of the PAM revealed region-specific and metabolic state-dependent differences in tonic DA levels and enhanced single-trial detection of behavior-evoked phasic DA release in cortex and striatum. Our chemogenetic strategy can potently and flexibly tune DA imaging sensitivity and reveal multi-modal (tonic/phasic) DA signaling across preparations and imaging approaches.

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Section: Resultsmentioning

confidence: 99%

A chemogenetic approach for dopamine imaging with tunable sensitivity

Labouesse,

Wilhelm,

Kagiampaki

et al. 2024

Nat Commun

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“…The insertion of the optical fiber into the brain, which is required to target subcortical regions, may have a similar impact on the tissue as the implantation of electrode arrays. By using multiple fibers in parallel, [87][88][89] several locations can be measured at the same time. Image-forming methods produce a spatial map of activity, either by forming an image directly onto a two-dimensional (2D) sensor, capturing image stacks or movies, or by creating a 2D image (or 3D volume) through sequential scanning of a focused laser beam 90,91 [Figs.…”

Section: Strengths and Limitations Of Optical Measurementsmentioning

confidence: 99%

Linking brain activity across scales with simultaneous opto- and electrophysiology

Lewis,

Hoffmann,

Helmchen

2023

Neurophoton.

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The brain enables adaptive behavior via the dynamic coordination of diverse neuronal signals across spatial and temporal scales: from fast action potential patterns in microcircuits to slower patterns of distributed activity in brain-wide networks. Understanding principles of multiscale dynamics requires simultaneous monitoring of signals in multiple, distributed network nodes. Combining optical and electrical recordings of brain activity is promising for collecting data across multiple scales and can reveal aspects of coordinated dynamics invisible to standard, singlemodality approaches. We review recent progress in combining opto-and electrophysiology, focusing on mouse studies that shed new light on the function of single neurons by embedding their activity in the context of brain-wide activity patterns. Optical and electrical readouts can be tailored to desired scales to tackle specific questions. For example, fast dynamics in single cells or local populations recorded with multi-electrode arrays can be related to simultaneously acquired optical signals that report activity in specified subpopulations of neurons, in non-neuronal cells, or in neuromodulatory pathways. Conversely, two-photon imaging can be used to densely monitor activity in local circuits while sampling electrical activity in distant brain areas at the same time. The refinement of combined approaches will continue to reveal previously inaccessible and under-appreciated aspects of coordinated brain activity.

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“…The cortico-basal ganglia-thalamo-cortical loops represent a fundamental network organizational principle of the brain that critically mediates a broad range of functional domains ranging from motor and behavioral control towards learning and reward-based processes. [69][70][71] Within this circuitry the MD and VM thalamus represent higher-order thalamic nuclei that relay and integrate an entire array of important signals, 72 whereas the basal ganglia complex represents a key regulator of reward and motor related processes 73,74 with bi-directional connections to the prefrontal cortex that facilitate adaptive control. 75 Connections of the MD and VM thalamus with the basal ganglia and frontal cortex in particular support: 1) flexible and goal directed behavior including reward value and effort computations via thalamic-striatal connections, 76,77 2) regulatory control and decision making via thalamo-frontal circuits.…”

Section: Target Engagement -Effects Of Acute At1r Blockade On Regiona...mentioning

confidence: 99%

The central renin angiotensin II system – a genetic pathway, functional decoding and selective target engagement characterization in humans

Chen

Zhou

et al. 2023

Preprint

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The brain renin angiotensin II system plays a pivotal role in cognition and neuropathology via the central angiotensin II type 1 receptor (AT1R), yet the lack of a biologically informed framework currently impedes translational and therapeutic progress. We combined imaging transcriptomic and meta-analyses with pharmaco-resting state fMRI employing a selective AT1R antagonist in a discovery-replication design (n=132 individuals). The AT1R was densely expressed in subcortical systems engaged in reward, motivation, stress, and memory. Pharmacological target engagement suppressed spontaneous neural activity in subcortical systems with high AT1R expression and enhanced functional network integration in cortico-basal ganglia-thalamo-cortical circuits. AT1R-regulation on functional network integration was further mediated by dopaminergic, opioid and corticotrophin-releasing hormone pathways. Overall, this work provides the first comprehensive characterization of the architecture and function of the brain renin angiotensin II system indicating that the central AT1R mediates human cognition and behavior via regulating specific circuits and interacting with classical transmitter systems.

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Dynamic reorganization of the cortico-basal ganglia-thalamo-cortical network during task learning

Cited by 6 publications

References 85 publications

A chemogenetic approach for dopamine imaging with tunable sensitivity

A chemogenetic approach for dopamine imaging with tunable sensitivity

Linking brain activity across scales with simultaneous opto- and electrophysiology

The central renin angiotensin II system – a genetic pathway, functional decoding and selective target engagement characterization in humans

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