Dynamic monitoring of platelet activation and its role in post-dissection inflammation in a canine model of acute type A aortic dissection

Qin, Chaoyi; Zhang, Hongwei; Gu, Jun; Xiao, Zhenghua; Yang, Qin; Meng, Wei

doi:10.1186/s13019-016-0472-5

Cited by 15 publications

(11 citation statements)

References 13 publications

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“…It has also been demonstrated that an inflammatory reaction can destroy the medial layer of the aorta and eventually lead to dilation, dissection and rupture of aortic wall [ 23 , 24 ]. Moreover, local inflammation in aortic wall and systemic inflammatory responses were observed during the whole course of AAD [ 9 , 10 , 25 ]. TLR4 is a useful marker for evaluating inflammatory response and vascular injury, and its activation plays a critical role in vascular remodeling [ 12 – 14 ].…”

Section: Discussionmentioning

confidence: 99%

Serum levels of matrix metalloproteinase 9 and toll-like receptor 4 in acute aortic dissection: a case-control study

Li¹,

Jun

Sun³

et al. 2018

BMC Cardiovasc Disord

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BackgroundMatrix metalloproteinase 9 (MMP9) and Toll-like receptor 4 (TLR4) play important roles in aortic pathophysiology. However, there is lacking research on serum TLR4 levels in acute aortic dissection (AAD) patients, and the performance of serum MMP9 and TLR4 for the diagnosis of AAD is still unknown. This study aimed to evaluate the serum levels of MMP9 and TLR4 in AAD patients, identify their associations with circulating C-reactive protein (CRP) and D-dimer, which are well-known classical biomarkers of AAD, and further explore the potential diagnostic role of MMP9 and TLR4 in AAD.MethodsSerum levels of MMP9 and TLR4 were measured by enzyme-linked immunosorbent assay (ELISA) in 88 AAD patients and 88 controls. The clinical test related information was collected from patients’ electronic medical records.ResultsSerum MMP9 and TLR4 levels were significantly higher in AAD patients than those in healthy controls in the general and stratified comparisons. Either serum MMP9 or TLR4 was independently associated with the risk of AAD (all p < 0.001). There was a positive significant association between serum MMP9 and TLR4 (r = 0.518, p < 0.001). Both MMP9 and TLR4 levels were statistically correlated with circulating CRP, but not D-dimer. Based on receiver-operating characteristic (ROC) analysis, the area under the curves (AUCs) of MMP9 and TLR4 alone for the diagnosis of AAD were 0.810 and 0.799 with optimal cut-off points of 379.47 ng/ml and 7.83 ng/ml, respectively. Moreover, a combination of serum MMP9 and TLR4 increased the AUC to 0.89 with a sensitivity of 60.2% and specificity of 94.3%.ConclusionsSerum MMP9 and TLR4 could be potential biomarkers for identifying AAD, while the combined diagnostic value was higher in safely ruling out AAD.

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Section: Discussionmentioning

confidence: 99%

Serum levels of matrix metalloproteinase 9 and toll-like receptor 4 in acute aortic dissection: a case-control study

Li¹,

Jun

Sun³

et al. 2018

BMC Cardiovasc Disord

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“…[2627] Qin et al . [28] have recently dynamically monitored the systemic inflammatory level and platelet activation with a new acute TAAD canine model. Their study found that both tumor necrosis factor-α and IL-6 were significantly climbed and reached highest levels at 6 h after the AD model was established.…”

Section: Discussionmentioning

confidence: 99%

Association of Plasma Pentraxin-3 Levels on Admission with In-hospital Mortality in Patients with Acute Type A Aortic Dissection

Zhou

Chai

Fang

et al. 2016

Chinese Medical Journal

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Background:Acute aortic dissection is a life-threatening cardiovascular emergency. Pentraxin-3 (PTX3) is proposed as a prognostic marker and found to be related to worse clinical outcomes in various cardiovascular diseases. This study sought to investigate the association of circulating PTX3 levels with in-hospital mortality in patients with acute Type A aortic dissection (TAAD).Methods:A total of 98 patients with TAAD between January 2012 and December 2015 were enrolled in this study. Plasma concentrations of PTX3 were measured upon admission using a high-sensitivity enzyme-linked immunosorbent assay system. Patients were divided into two groups as patients died during hospitalization (Group 1) and those who survived (Group 2). The clinical, laboratory variables, and imaging findings were analyzed between the two groups, and predictors for in-hospital mortality were evaluated using multivariate analysis.Results:During the hospital stay, 32 (33%) patients died and 66 (67%) survived. The patients who died during hospitalization had significantly higher PTX3 levels on admission compared to those who survived. Pearson's correlation analysis demonstrated that PTX3 correlated positively with high-sensitivity C-reactive protein (hsCRP), maximum white blood cell count, and aortic diameter. Multivariate logistic regression analysis demonstrated that PTX3 levels, coronary involvement, cardiac tamponade, and a conservative treatment strategy are significant independent predictors of in-hospital mortality in patients with TAAD. The receiver operating characteristic curve analysis further illustrated that PTX3 levels on admission were strong predictors of mortality with an area under the curve of 0.89. A PTX3 level ≥5.46 ng/ml showed a sensitivity of 88% and a specificity of 79%, and an hsCRP concentration ≥9.5 mg/L had a sensitivity of 80% and a specificity of 69% for predicting in-hospital mortality.Conclusion:High PTX3 levels on admission are independently associated with the in-hospital mortality in patients with TAAD.

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“…The activated PLT in the false lumens form a thrombus, resulting in a drop in the PLT count in the body. Chaoyi Qin et al [13] proved that the PLT count (K/ul) in aortic dissection is lower than chronic aortic aneurysm and healthy people. This change of PLT count may be related to extent of dissection, and is consistent with the findings of earlier study by Tanaka et al [14].…”

Section: Discussionmentioning

confidence: 99%

The Significance of Platelet Count in Short-Term Prognosis of Type B Acute Aortic Dissection Patients

Shao¹,

Yao²,

Ya-bin³

2021

IJBSE

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Background: The lower number of platelet (PLT) has been found to be a risk factor in patients with type A acute aortic dissection (AAD) In admission. However prognostic implications of the PLT count in the type B AAD patients has not yet been elucidated. Methods: We consecutively enrolled 81 patients which confirmed with type B. Patients were divided into survival group and death group and PLT count were measured on admission. Univariate analysis and multiple logistic regression analysis were used to identify the predictors of in-hospital mortality. Results: Compared with the survival group, the death group PLT count was significant lower (172.07±57.38×10 9 /L vs. 227.13±75.97×10 9 /L, P<0.05). The results showed PLT count (HR: 0.993, 95% CI: 0.987-0.997, P=0.043), the area under the ROC curve of PLT count was 0.717, the best cut off was 179.5 × 10 9 / L, the sensitivity was 72.5%, the specificity was 63.3%, P=0.001; Log Rang test results showed that there was a statistically significant difference in cumulative survival between the high PLT count group (>179.5 × 10 9 / L) and the low PLT count group (<179.5 × 10 9 / L) (P=0.001). Conclusions: Low PLT on admission count is one of the specific dead risk factors for type B AAD in-hospital patients.

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Dynamic monitoring of platelet activation and its role in post-dissection inflammation in a canine model of acute type A aortic dissection

Cited by 15 publications

References 13 publications

Serum levels of matrix metalloproteinase 9 and toll-like receptor 4 in acute aortic dissection: a case-control study

Serum levels of matrix metalloproteinase 9 and toll-like receptor 4 in acute aortic dissection: a case-control study

Association of Plasma Pentraxin-3 Levels on Admission with In-hospital Mortality in Patients with Acute Type A Aortic Dissection

The Significance of Platelet Count in Short-Term Prognosis of Type B Acute Aortic Dissection Patients

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