Dynamic moisture sorption and desorption of standard and silicified microcrystalline cellulose

Kachrimanis, Kyriakos; Noisternig, Michael F.; Griesser, Ulrich J.; Malamataris, S.

doi:10.1016/j.ejpb.2006.05.019

Cited by 60 publications

(48 citation statements)

References 27 publications

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“…Analysis of water vapour and anisole sorption isotherms using the GAB model A number of models have been used to describe the sorption isotherms of cellulose (one example can be found in the article by Kachrimanis et al 2006). The models most widely used are the Brunauer-EmmettTeller (BET) isotherm, the Guggenheim, Anderson and De Boer (GAB) isotherm, the Young and Nielson model, Parallel Exponential Kinetics (PEK), the Park model or New Dual-Mode Sorption.…”

Section: Anisole and Cyclohexane Adsorptionmentioning

confidence: 99%

“…Primary CNC, like MCC, suffer irreversible aggregation due to strong hydrogen bonding between the particles once they are dried (Eyley and Thielemans 2014). For example, hornification following the drying of MCC is a major problem encountered in the formulation of pharmaceutical excipients (Kachrimanis et al 2006). Surface grafting to reduce inter-particle hydrogen bonding is one of the solutions to this problem (Habibi et al 2010).…”

Section: Introductionmentioning

confidence: 98%

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Cellulose nanocrystal surface functionalization for the controlled sorption of water and organic vapours

et al. 2016

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The surface grafting of cellulose nanocrystals (CNC) is a valuable tool to increase opportunities for their application. This work had several goals designed to improve CNC: reduction of hornification, increased re-dispersibility after CNC drying, and tuning of the surface graft to enhance the adsorption of particular molecules. To achieve this, the CNC surfaces were modified chemically with aromatic surface grafts using widely employed methods: the creation of urethane linkages, silylation and esterification. Even a low degree of grafting sufficed to increase water contact angles to as much as 96°. The analysis of water sorption isotherms showed that at high water activities, capillary condensation could be suppressed and hysteresis was decreased. This indicates that hornification was significantly suppressed. However, although the contact angles increased, the water sorption isotherms were changed only slightly because of reduced hysteresis. The grafts were not able to shield the surface from water vapour sorption. A comparison of the sorption isotherms of anisole and cyclohexane, sorbates with a similar surface area, showed that the sorption of anisole was three times higher than that of cyclohexane. The specific sorption of aromatic molecules was achieved and the most efficient methodology was the esterification of CNC with carboxylic acids containing a flexible linker between the aromatic moiety and ester bond.

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Section: Anisole and Cyclohexane Adsorptionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Cellulose nanocrystal surface functionalization for the controlled sorption of water and organic vapours

et al. 2016

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“…It has been demonstrated that the water vapour sorption behaviour of natural fibres (Kohler et al 2003;Hill et al 2010a;Xie et al 2010a), regenerated cellulose fibres (Okubayashi et al 2004(Okubayashi et al , 2005a, microcrystalline cellulose (Kachrimanis et al 2006), wood flour (Hill et al 2010b, c;Jalaludin et al 2010;Xie et al 2010b, c) and some foodstuffs (Madamba et al 1996;Rahman et al 1998;Tang et al 2008), can be accurately described using the parallel exponential kinetics (PEK) model (Eq. 1).…”

Section: Introductionmentioning

confidence: 98%

The water vapour sorption behaviour of three celluloses: analysis using parallel exponential kinetics and interpretation using the Kelvin-Voigt viscoelastic model

et al. 2011

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The objective of this study was to examine the water vapour sorption behaviour of three celluloses, which were originally derived from cotton fibers, using a dynamic vapour sorption apparatus, including analyses of the sorption rate and hysteresis occurring in the isotherm run. Cotton linter, a-cellulose, and microcrystalline cellulose (MCC), respectively attained equilibrium moisture contents of 14.2, 20.6, and 16.9% at a relative humidity (RH) of 95%. All three cellulosic materials exhibited sorption hysteresis to varying degrees throughout the full RH range; the MCC and a-cellulose displayed the lowest and highest total hysteresis, respectively. The sorption kinetics were analysed in terms of the parallel exponential kinetics (PEK) model, with excellent fits to the data being obtained. The PEK data is further interpreted on the basis of two Kelvin-Voigt elements operating in series. Clear differences in behaviour were seen between the a-cellulose and the other two celluloses in this study. The relative importance of capillary condensation and matrix viscoelasticity with respect to sorption hysteresis is discussed.

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“…The results on water vapour sorption on all the measured MCCs are in good agreement with previously published results. Adsorption isotherms can be described as the type II (BET) adsorption isotherms (25,26). The results on sorption, desorption and hysteresis obtained from the DVS results at 75 % relative humidity (Table III) were used in the study of the influence of adsorbed water on MCC on the stability of PER and EM in mixtures with different types of MCC.…”

Section: Physicochemical Properties Of MCC Powders That Could Influenmentioning

confidence: 99%

Influence of different types of commercially available microcrystalline cellulose on degradation of perindopril erbumine and enalapril maleate in binary mixtures / Vpliv različnih tipov komercialno dostopne mikrokristalne celuloze na razpad erbuminijevega perindoprilata in enalaprilijevega maleata v binarnih zmeseh

Vehovec¹,

Gartner²,

Planinšek³

et al. 2012

Acta Pharmaceutica

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Numerous types of microcrystalline cellulose (MCC) are available on the market for a variety of uses in pharmaceutical industry. They can be used as adsorbents, anti-adherents, binders/diluents and tablet disintegrants (1). On the industrial scale, MCC is obtained by hydrolysis of wood and cotton cellulose using dilute mineral acids. The treated pulp is then rinsed and spray-dried with or without an additional process step such as milling. Cellulose from different sources differs in the properties such as crystallinity, moisture content, surface area, porous structure, molecular mass. These properties can be also affected by the conditions of hydrolysis. Preparations of MCC from materials other than wood and cotton (e.g., water hyacinth, coconut shells, wheat and rice straws, etc.) have also been reported (2). Influence of some commercially available types of microcrystalline cellulose (MCC) on the stability of certain active pharmaceutical ingredients (APIs), when in contact, has been investigated. Two structurally similar APIs, perindopril erbumine (PER) and enalapril maleate (EM), both well-known angiotensin-converting enzyme inhibitors were used. The main properties of an MCC that could determine the stability for each API were measured and correlated to the stability of these two APIs in binary mixtures. The stability of these APIs differed when in contact with different types of MCC. The dominant properties of MCC from one manufacturer were surface features that influenced the stability of PER and acidity that influenced the stability of EM. In the case of MCC from other manufacturers, unbound water was stability determining for both substances.

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Dynamic moisture sorption and desorption of standard and silicified microcrystalline cellulose

Cited by 60 publications

References 27 publications

Cellulose nanocrystal surface functionalization for the controlled sorption of water and organic vapours

Cellulose nanocrystal surface functionalization for the controlled sorption of water and organic vapours

The water vapour sorption behaviour of three celluloses: analysis using parallel exponential kinetics and interpretation using the Kelvin-Voigt viscoelastic model

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