Dynamic Modulation of Enzyme Activity by Near‐Infrared Light

Wang, Changping; Zhang, Qiang; Wang, Xinyu; Chang, Hong; Zhang, Sanjun; Tang, Yuankai; Xu, Jianhua; Qi, Ruijuan; Cheng, Yiyun

doi:10.1002/ange.201700968

Cited by 38 publications

(19 citation statements)

References 51 publications

(47 reference statements)

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“…As a result, the complexation of these fluoroamphiphiles with BSA, an anionic protein at pH 7.4, leads to the decrease of zeta-potential of formed nanoparticles. We further labeled BSA with platinum (Pt) nanoparticles 57 . The TEM results in Fig.…”

Section: Resultsmentioning

confidence: 99%

The fluorination effect of fluoroamphiphiles in cytosolic protein delivery

et al. 2018

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Direct delivery of proteins into cells avoids many drawbacks of gene delivery, and thus has emerging applications in biotherapy. However, it remains a challenging task owing to limited charges and relatively large size of proteins. Here, we report an efficient protein delivery system via the co-assembly of fluoroamphiphiles and proteins into nanoparticles. Fluorous substituents on the amphiphiles play essential roles in the formation of uniform nanoparticles, avoiding protein denaturation, efficient endocytosis, and maintaining low cytotoxicity. Structure-activity relationship studies reveal that longer fluorous chain length and higher fluorination degree contribute to more efficient protein delivery, but excess fluorophilicity on the polymer leads to the pre-assembly of fluoroamphiphiles into stable vesicles, and thus failed protein encapsulation and cytosolic delivery. This study highlights the advantage of fluoroamphiphiles over other existing strategies for intracellular protein delivery.

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Section: Resultsmentioning

confidence: 99%

The fluorination effect of fluoroamphiphiles in cytosolic protein delivery

et al. 2018

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“…[27] NIR absorbing TTA-UC is advantageous in biological applications such as deep tissue penetration and weak photo-damage for the organism. [28][29] PdPc (OBu) 8 was proposed to use due to its intense absorbance in NIR region. When combined with a rubene emitter, NIR to visible light upconversion was able to be detected.…”

Section: The Basic Theory and Principles Of Tta-ucmentioning

confidence: 99%

Designing next generation of photon upconversion: Recent advances in organic triplet-triplet annihilation upconversion nanoparticles

et al. 2019

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Organic triplet-triplet annihilation upconversion (TTA-UC) nanoparticles have emerged as exciting therapeutic agents and imaging probes in recent years due to their unique chemical and optical properties such as outstanding biocompatibility and low power excitation density. In this review, we focus on the latest breakthroughs in such new version of upconversion nanoparticle, including their design, preparation, and applications. First, we will discuss the key principles and design concept of these organic-based photon upconversion in regard to the methods of selection of the related triplet TTA dye pairs (photosensitizer and emitter). Then, we will discuss the recent approaches s to construct TTA-UCNPs including silica TTA-UCNPs, lipid-coated TTA-UCNPs, polymer encapsulated TTA-UCNPs, nano-droplet TTA-UCNPs and metal-organic frameworks (MOFs) constructed TTA-UCNPs. In addition, the applications of TTA-UCNPs will be discussed. Finally, we will discuss the challenges posed by current TTA-UCNP development.

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“…For instance, the method of adjusting enzyme activity by NIR illumination is facile and feasible. It has been reported that platinum nanoparticles (PtNPs) within an enzyme allow local heating through the photothermal effect of the PtNPs upon NIR irradiation and consequently tailoring the enzyme activity (Wang et al 2017).…”

Section: Introductionmentioning

confidence: 99%

Preparation of injectable hydrogel with near-infrared light response and photo-controlled drug release

Zhao

Liang

Tan

2020

Bioresour. Bioprocess.

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Photo-controlled release hydrogel provides a new strategy for treating tumours. Under the stimulation of external light sources, the ability to release the entrapped drug on time and space on demand has outstanding advantages in improving drug utilisation, optimising treatment, and reducing toxicity and side effects. In this study, a photocontrolled drug delivery system for disulphide cross-linked polyaspartic acid (PASP-SS) hydrogels encapsulating proteinase K (ProK) adsorbed with platinum nanoparticles (PtNPs) was designed. The injectable cysteamine-modified polyaspartic acid (PASP-SH) sol and PtNPs adsorbed by ProK (ProK-PtNPs) as regulatory factors were prepared. Then, ProK-PtNPs and lentinan were dissolved in the sol, and the oxidant was added to the matrix to form the gel in situ quickly after injection. Finally, the degradation of PASP-SS hydrogel by ProK and the controllability of drug release under near-infrared (NIR) light irradiation were elucidated. In vitro degradation of hydrogels and drug release experiments showed that the degradation rate of PASP-SS hydrogel significantly increased and the drug release rate increased significantly under near-infrared radiation. The results of cytotoxicity test showed that PASP-SS, ProK-PtNPs, and lentinan all had more than 90% cell survival rate on NIH3T3, and the lentinan released from the carrier obviously inhibited the proliferation of MCF7. PASP hydrogel has the potential to respond to on-demand light control. Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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Dynamic Modulation of Enzyme Activity by Near‐Infrared Light

Cited by 38 publications

References 51 publications

The fluorination effect of fluoroamphiphiles in cytosolic protein delivery

The fluorination effect of fluoroamphiphiles in cytosolic protein delivery

Designing next generation of photon upconversion: Recent advances in organic triplet-triplet annihilation upconversion nanoparticles

Preparation of injectable hydrogel with near-infrared light response and photo-controlled drug release

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