2019
DOI: 10.1101/633891
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Abstract: Signal integration in the mTOR pathway plays a vital role in cell fate decision making in cancer cells.As a signal integrator, mTOR shows a complex dynamical behavior which determines the cell fate at different cellular processes levels including cell cycle progression, cell survival, cell death, metabolic reprogramming, and aging. The dynamics of the complex responses to rapamycin in cancer cells have been attributed to its differential time-dependent inhibitory effects on mTORC1 and mTORC2, the two main comp… Show more

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