Dynamic association of ambient air pollution with incidence and mortality of pulmonary hypertension: A multistate trajectory analysis

Shi, Hui; Chen, Lan; Zhang, Shiyu; Li, Rui; Wu, Yinglin; Zou, Hongtao; Wang, Chongjian; Cai, Miao; Lin, Hualiang

doi:10.1016/j.ecoenv.2023.115126

Cited by 4 publications

(3 citation statements)

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“…A recent UK Biobank analysis of almost 500,000 participants found that the combination of air pollution and smoking had a synergistic effect on the incidence and mortality of PH, and even never-smokers had a higher risk of PH with increased exposure to PM 2.5 , PM 10 , NO 2 , and NO x . 36 In a randomized cross-over trial, 18 healthy subjects exposed for 2 h to diesel exhaust had no increase of echocardiography-measured pulmonary vascular resistance at rest, but showed an increase in pulmonary artery pressure to cardiac output slope and…”

Section: Populations-based and Healthy Subjects Studies On Pulmonary ...mentioning

confidence: 99%

“…43 ↑ incidence and mortality of PH associated with air pollutants. 36 Acute exposure to diesel exhaust ↑pulmonary vasomotor tone by ↓distensibility of pulmonary vessels at high cardiac output. 37 DE is associated with ↑ pulmonary vessels volume on CT scans.…”

Section: Pvd Subgroup Main Findingsmentioning

confidence: 99%

“…A recent UK Biobank analysis of almost 500,000 participants found that the combination of air pollution and smoking had a synergistic effect on the incidence and mortality of PH, and even never‐smokers had a higher risk of PH with increased exposure to PM 2.5 , PM 10 , NO 2 , and NO x 36 . In a randomized cross‐over trial, 18 healthy subjects exposed for 2 h to diesel exhaust had no increase of echocardiography‐measured pulmonary vascular resistance at rest, but showed an increase in pulmonary artery pressure to cardiac output slope and decreased pulmonary distensibility during dobutamine stress test; the study found no difference in serum ET‐1 and fractional exhaled NO 37 .…”

Section: Direct and Indirect Impact Of Climate Change On Pvdmentioning

confidence: 99%

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Pulmonary vascular disease, environmental pollution, and climate change

Lichtblau,

Reimann,

Piccari

2024

Pulm. circ.

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Pollution and climate change constitute a combined, grave and pervasive threat to humans and to the life‐support systems on which they depend. Evidence shows a strong association between pollution and climate change on cardiovascular and respiratory diseases, and pulmonary vascular disease (PVD) is no exception. An increasing number of studies has documented the impact of environmental pollution and extreme temperatures on pulmonary circulation and the right heart, on the severity and outcomes of patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension (PH), on the incidence of pulmonary embolism, and the prevalence and severity of diseases associated with PH. Furthermore, the downstream consequences of climate change impair health care systems' accessibility, which could pose unique obstacles in the case of PVD patients, who require a complex and sophisticated network of health interventions. Patients, caretakers and health care professionals should thus be included in the design of policies aimed at adaptation to and mitigation of current challenges, and prevention of further climate change. The purpose of this review is to summarize the available evidence concerning the impact of environmental pollution and climate change on the pulmonary circulation, and to propose measures at the individual, healthcare and community levels directed at protecting patients with PVD.

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Section: Populations-based and Healthy Subjects Studies On Pulmonary ...mentioning

confidence: 99%

Section: Pvd Subgroup Main Findingsmentioning

confidence: 99%

“…A recent UK Biobank analysis of almost 500,000 participants found that the combination of air pollution and smoking had a synergistic effect on the incidence and mortality of PH, and even never‐smokers had a higher risk of PH with increased exposure to PM 2.5 , PM 10 , NO 2 , and NO x 36 . In a randomized cross‐over trial, 18 healthy subjects exposed for 2 h to diesel exhaust had no increase of echocardiography‐measured pulmonary vascular resistance at rest, but showed an increase in pulmonary artery pressure to cardiac output slope and decreased pulmonary distensibility during dobutamine stress test; the study found no difference in serum ET‐1 and fractional exhaled NO 37 .…”

Section: Direct and Indirect Impact Of Climate Change On Pvdmentioning

confidence: 99%

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