DW MRI at 3.0 T versus FDG PET/CT for detection of malignant pulmonary tumors

Zhang, Jiän; Cui, Long‐Biao; Tang, Xing; Ren, Xue; Shi, Junnan; Yang, Hainan; Zhang, Yan; Li, Zhikui; Wu, Changgui; Wen, Jianbo; Zhao, Feng; Ti, Xinyu; Yin, Hong

doi:10.1002/ijc.28394

Cited by 32 publications

(38 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The model yielded an average adjusted estimate of sensitivity of 89% (95% CI, 87%-91%) and specificity of 75% (95% CI, 71%-78%) (Figure 2) 30-89 .…”

Section: Resultsmentioning

confidence: 99%

Accuracy of FDG-PET to Diagnose Lung Cancer in Areas With Infectious Lung Disease

Deppen

Blume

Kensinger

et al. 2014

JAMA

153

119

View full text Add to dashboard Cite

Importance Positron emission tomography (PET) with 18-fluorodeoxyglucose (FDG) is recommended for the non-invasive diagnosis of pulmonary nodules suspicious for lung cancer. In populations with endemic infectious lung disease, FDG-PET may not accurately identify malignant lesions. Objective To estimate the diagnostic accuracy of FDG-PET for pulmonary nodules suspicious for lung cancer in regions where infectious lung disease is endemic and compare the test accuracy in regions where infectious lung disease is rare. Data Sources and Study Selection Databases of MEDLINE, EMBASE and the Web of Science were searched from October 1, 2000, through April 28, 2014. Articles reporting information sufficient to calculate sensitivity and specificity of FDG-PET to diagnose lung cancer were included. Only studies that enrolled more than 10 participants with benign and malignant lesions were included. Database searches yielded 1923 articles, of which 257 were assessed for eligibility. Seventy studies were included in the analysis. Studies reported on a total of 8511 nodules; 5105 (60%) were malignant. Data Extraction and Synthesis Abstracts meeting eligibility criteria were collected by a research librarian and reviewed by 2 independent reviewers. Hierarchical summary receiver operating characteristic curves were constructed. A random-effects logistic regression model was used to summarize and assess the effect of endemic infectious lung disease on test performance. Main Outcome and Measures The sensitivity and specificity for FDG-PET test performance. Results Heterogeneity for sensitivity (I2=87%) and specificity (I2=82%) was observed across studies. The pooled (unadjusted) sensitivity was 89% (95% CI, 86%-91%) and specificity was 75% (95% CI, 71%-79%). There was a 16% lower average adjusted specificity in regions with endemic infectious lung disease (61% [95% CI, 49%-72%]) compared with nonendemic regions (77% [95% CI, 73%-80%]). Lower specificity was observed when the analysis was limited to rigorously conducted and well-controlled studies. In general, sensitivity did not change appreciably by endemic infection status, even after adjusting for relevant factors. Conclusions and Relevance The accuracy of FDG-PET for diagnosing lung nodules was extremely heterogeneous. Use of FDG-PET combined with computed tomography was less specific in diagnosing malignancy in populations with endemic infectious lung disease compared with nonendemic regions. These data do not support use of FDG-PET to diagnose lung cancer in endemic areas unless an institution achieves test performance accuracy similar to that found in nonendemic regions.

show abstract

“…The model yielded an average adjusted estimate of sensitivity of 89% (95% CI, 87%-91%) and specificity of 75% (95% CI, 71%-78%) (Figure 2) 30-89 .…”

Section: Resultsmentioning

confidence: 99%

Accuracy of FDG-PET to Diagnose Lung Cancer in Areas With Infectious Lung Disease

Deppen

Blume

Kensinger

et al. 2014

JAMA

153

119

View full text Add to dashboard Cite

show abstract

“…5 ADC values also correlate with tumour grades. 4,17,18 Recent studies have shown that ADC may be more useful than FDG-PET in the differentiation of malignant tumours from benign lesions 3,6 and the new approaches using PET\MRI may provide more promising results in the future. 33 Among primary lung cancers, ADC values are usually low in cases with small cell carcinomas, but the values for adenocarcinomas and squamous cell carcinomas are usually similar.…”

Section: Discussionmentioning

confidence: 99%

“…It has been increasingly used for the detection, differential diagnosis and evaluation of tumour characteristics, including grading and prediction of the therapeutic response. [1][2][3][4][5][6][7] DW-MRI is a functional imaging technique that reveals physiological information by quantifying the diffusion of water molecules in tissues. The extent of this diffusion is measured using the apparent diffusion coefficient (ADC).…”

Section: Introductionmentioning

confidence: 99%

“…[13][14][15][16][17][18][19] The Ki-67 index has also been used routinely in the evaluation of lung tumours and has been shown to be an important prognostic factor for lung cancer. 3,6,[20][21][22][23][24][25][26][27] Although a few studies have evaluated the association of ADC with Ki-67 index in lung tumours 3,6 , no study has previously investigated differences in the ADC/Ki 67 correlation in different tumour subtypes.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Correlation of diffusion MRI with the Ki-67 index in non-small cell lung cancer

et al. 2016

View full text Add to dashboard Cite

Disclosure: No potential conflicts of interest were disclosed.Background. The primary objective of the study was to evaluate the association between the minimum apparent diffusion coefficient (ADC min ) and Ki-67, an index for cellular proliferation, in non-small cell lung cancers. Also, we aimed to assess whether ADC min values differ between tumour subtypes and tissue sampling method.Methods. The patients who had diffusion weighted magnetic resonance imaging (DW-MRI) were enrolled retrospectively. The correlation between ADC min and the Ki-67 index was evaluated.Results. Ninety three patients, with a mean age 65 ± 11 years, with histopathologically proven adenocarcinoma and squamous cell carcinoma of the lungs and had technically successful DW-MRI were included in the study. The numbers of tumour subtypes were 47 for adenocarcinoma and 46 for squamous cell carcinoma. There was a good negative correlation between ADC min values and the Ki-67 proliferation index (r = -0.837, p < 0.001). The mean ADC min value was higher and the mean Ki-67 index was lower in adenocarcinomas compared to squamous cell carcinoma (p < 0.0001). There was no statistical difference between tissue sampling methods.Conclusions. Because ADC min shows a good but negative correlation with Ki-67 index, it provides an opportunity to evaluate tumours and their aggressiveness and may be helpful in the differentiation of subtypes non-invasively.

show abstract

“…23 Qualitative and quantitative assessments of the tumor were also higher with DWI than with PET/CT. 24 The detection rate depends on the b value, with lower SI at higher b values, which makes detection of ground-glass nodules difficult at higher b values (1000 s/mm 2 ). 20 However, a study on 25 patients showed that DWI as a part of WB-[ 18 F]-FDG-PET/MRI did not improve lesion detection.…”

Section: Nodule Sizementioning

confidence: 99%