Duration of viable SARS-CoV-2 shedding from respiratory tract in different human hosts and its impact on isolation discontinuation polices revision; a narrative review

Qutub, Mohammed; Aldabbagh, Yasser; Mehdawi, Fahtima; Alraddadi, Abdullah; Alhomsy, Mohanna; Alnahdi, Abdulaziz; Fakeeh, Majed; maghrabi, Abdullah; Alwagdani, Meshari; Bahabri, Nezar

doi:10.1016/j.clinpr.2022.100140

Cited by 13 publications

(16 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A recent study showed that the symptomatic COVID-19 cases across each variant, including Omicron, had higher viral loads than the asymptomatic cases [22]. Besides, the larger number of clinical symptoms and lower Ct values were shown to be associated with a longer LOS and slower viral clearance [6,8], which were consistent with the longer LOS in mild cases compared with asymptomatic ones in this study. Age was another important factor previously reported to be associated with a worse outcome, including disease progression, in-hospital mortality, as well as prolonged duration of viral shedding, in COVID-19 patients [28][29][30][31][32].…”

Section: Discussionsupporting

confidence: 86%

“…The Ct values of RT-PCR tests for SARS-CoV-2 are the most acknowledged and convenient indicator for viral load in COVID-19 patients at present [27,28]. The low Ct values were shown to be associated with delayed clearance of viral RNA in patients infected with previous SARS-CoV-2 variants [8,9], and our findings further supported that it could be the same case in Omicron-infected patients. A recent study showed that the symptomatic COVID-19 cases across each variant, including Omicron, had higher viral loads than the asymptomatic cases [22].…”

Section: Discussionsupporting

confidence: 78%

“…A few studies on COVID-19 patients during the Omicron wave showed that their median length of hospital stay (LOS) was 3-3.2 days [4,5]. Meanwhile, age, more severe clinical symptoms, non-vaccination, comorbidities, and low cycle threshold (Ct) values of the RT-PCR tests were shown to be associated with prolonged viral clearance and LOS in patients infected with previous variants [6][7][8][9][10]. Since Omicron is the dominant disease-causing variant at present and the majority of Omicron-infected COVID-19 patients were reported to be asymptomatic and mild cases [11][12][13][14][15], this study aims to demonstrate the clinical characteristics and LOS in a cohort of asymptomatic and mild COVID-19 patients during the wave of the Omicron epidemic in Shanghai from the largest municipal-level makeshift hospital with a capacity of 50,000 beds, the National Exhibition and Convention Center (NECC) Makeshift Hospital, and to investigate the risk factors for the prolonged LOS due to prolonged duration of viral shedding.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Clinical characteristics and risk factors for a prolonged length of stay of patients with asymptomatic and mild COVID-19 during the wave of Omicron from Shanghai, China

Liu

Sun

et al. 2022

BMC Infect Dis

View full text Add to dashboard Cite

Background This study aims to investigate the clinical characteristics and the length of hospital stay (LOS), as well as risk factors for prolonged LOS in a cohort of asymptomatic and mild COVID-19 patients infected with the Omicron variant. Methods A total of 1166 COVID-19 patients discharged from the inpatient ward of the largest makeshift hospital (May 8–10, 2022) in Shanghai, China, were included. The demographics, medical history, and the lowest and admission cycle threshold (Ct) values of the RT-PCR tests for SARS-CoV-2 genes of the open reading frame 1ab (Ct-ORF) and the nucleocapsid protein (Ct-N) during hospitalization were recorded. Patients with LOS > 7 days, or LOS ≤ 7 days were included in the Prolonged group or the Control group, separately. The clinical characteristics and LOS of the participants in the two groups were described and compared. Multivariate Logistic and linear regression analyses were applied to explore the risk factors for prolonged LOS. The diagnostic efficacy of the lowest and admission Ct values for the Prolonged group was tested via the receiver operating characteristic (ROC) curve analysis. Results The median LOS was 6 days in the total study population. The age was older (45.52 ± 14.78 vs. 42.54 ± 15.30, P = 0.001), while both the lowest and admission Ct-ORF (27.68 ± 3.88 vs. 37.00 ± 4.62, P < 0.001; 30.48 ± 5.03 vs. 37.79 ± 3.81, P < 0.001) and Ct-N (25.79 ± 3.60 vs. 36.06 ± 5.39, P < 0.001; 28.71 ± 4.95 vs. 36.95 ± 4.59, P < 0.001) values were significantly lower in the Prolonged group. There were more mild cases in the Prolonged group (23.8% vs. 11.5%, P < 0.001). The symptom spectrum differed between the two groups. In multivariate analyses, age, disease category, and the lowest Ct-N values were shown to be associated with prolonged LOS. Besides, both the lowest and admission Ct-ORF (AUC = 0.911 and 0.873) and Ct-N (AUC = 0.912 and 0.874) showed robust diagnostic efficacy for prolonged LOS. Conclusions Our study firstly reports the clinical characteristics and risk factors for prolonged LOS during the wave of the Omicron epidemic in Shanghai, China. These findings provide evidence for the early identification of asymptomatic and mild COVID-19 patients at a high risk of prolonged hospitalization who may require early intervention, and long-term monitoring and management.

show abstract

Section: Discussionsupporting

confidence: 86%

Section: Discussionsupporting

confidence: 78%

mentioning

confidence: 99%

See 1 more Smart Citation

Clinical characteristics and risk factors for a prolonged length of stay of patients with asymptomatic and mild COVID-19 during the wave of Omicron from Shanghai, China

Liu

Sun

et al. 2022

BMC Infect Dis

View full text Add to dashboard Cite

show abstract

“…Regarding the magnitude of viral shedding, studies report high variations of temporal viral shedding patterns among individuals (38)(39)(40). In addition, the duration of viral shedding can be highly heterogeneous, with pooled estimates of mean durations ranging from 11.1 days to 30.3 days, and almost all reviews report high heterogeneity of estimates identified from literatures (37,(41)(42)(43)(44)(45)(46)(47)(48)(49)(50). Such heterogeneities still exist in subgroup analyses by age and severity (37,(41)(42)(43)(44)(45)50).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, the duration of viral shedding can be highly heterogeneous, with pooled estimates of mean durations ranging from 11.1 days to 30.3 days, and almost all reviews report high heterogeneity of estimates identified from literatures (37,(41)(42)(43)(44)(45)(46)(47)(48)(49)(50). Such heterogeneities still exist in subgroup analyses by age and severity (37,(41)(42)(43)(44)(45)50). Also, the infectious period, proxied by duration of replicant competent virus isolation, is also heterogeneous (50).…”

Section: Discussionmentioning

confidence: 99%

The effect of variation of individual infectiousness on SARS-CoV-2 transmission in households

Tsang

Huang

Wang

et al. 2022

Preprint

View full text Add to dashboard Cite

Quantifying variation of individual infectiousness is critical to inform disease control. Previous studies reported substantial heterogeneity in transmission of many infectious diseases (including SARS-CoV-2). However, those results are difficult to interpret since the number of contacts is rarely considered in such approaches. Here, we analyze data from 17 SARS-CoV-2 household transmission studies conducted in periods dominated by ancestral strains, in which the number of contacts was known. By fitting individual-based household transmission models to these data, accounting for number of contacts and baseline transmission probabilities, the pooled estimate suggests that the 20% most infectious cases have 3.1-fold (95% confidence interval: 2.2-4.2 fold) higher infectiousness than average cases, which is consistent with the observed heterogeneity in viral shedding. Household data can inform the estimation of transmission heterogeneity, which is important for epidemic management.One Sentence SummaryIn this study, variation of individual infectiousness is quantified. Potential sources of such variation, particularly heterogeneity of viral shedding is discussed.

show abstract

Determination of airborne influenza virus and coronavirus infectivity using capsid integrity polymerase chain reaction

Choi,

Piri,

Jung

et al. 2024

Journal of Hazardous Materials

View full text Add to dashboard Cite

Duration of viable SARS-CoV-2 shedding from respiratory tract in different human hosts and its impact on isolation discontinuation polices revision; a narrative review

Cited by 13 publications

References 30 publications

Clinical characteristics and risk factors for a prolonged length of stay of patients with asymptomatic and mild COVID-19 during the wave of Omicron from Shanghai, China

Clinical characteristics and risk factors for a prolonged length of stay of patients with asymptomatic and mild COVID-19 during the wave of Omicron from Shanghai, China

The effect of variation of individual infectiousness on SARS-CoV-2 transmission in households

Determination of airborne influenza virus and coronavirus infectivity using capsid integrity polymerase chain reaction

Contact Info

Product

Resources

About