Dural Sinus Thrombosis in Leukemia

Hemorrhagic Infarction of the Basal Ganglia

“…Multifocal infarctions of small cerebral vessels have been described in association with generalized infec tions. Signs of disseminated intravascular coagulation with multiple thrombi in the microvasculature of other organs were detected in these patients [1,4], Recently, rare cases of cerebral arterial thrombosis have been observed in children with ALL either during initial induction chemotherapy [5] or during complete remission, several months after CNS prophylaxis [6], Thrombosis of the superior sagittal sinus in leukemia has been described with leukemic infiltration of the sinus walls [7] and in the absence of any manifest cause [8][9][10], In the fatal cases throm bosis had spread within the dural sinus system to the cerebral veins resulting in extensive hemorrhagic in farctions. Isolated thrombosis of the deep cerebral venous (Galenic) system and, in particular, primary thrombosis of both internal cerebral veins with con secutive bilateral hemorrhagic infarction of the basal ganglia (case 1 in this paper) is rare among the spec trum of cerebral venous thromboses [11][12][13] and has, to our knowledge, not been reported in connection with leukemia.…”

Dural sinus thrombosis in children with cancer

“…Obstruction of venous drain age can be due to invasion or compression of sinuses by the neoplasm [25]. Thrombosis as a " paraneoplastic" phenomenon is another possibility [1], Thrombosis of the sagittal sinus has been reported in children with cancer [3][4][5][6]8,26,27]. The first observa tions were made in children with leukaemia [3][4][5][6].…”

“…Thrombosis as a " paraneoplastic" phenomenon is another possibility [1], Thrombosis of the sagittal sinus has been reported in children with cancer [3][4][5][6]8,26,27]. The first observa tions were made in children with leukaemia [3][4][5][6]. This complication can be ascribed to hypercoagulability due to the asparaginase-induced antithrombin III deficiency [7].…”

Superior sagittal sinus thrombosis in blastic crisis of chronic myelogenous leukemia. A case report of a complete recovery.

“…myelogenous leukemia (CML) is now better than 30% and it has become necessary to place attention on reducing or eliminating complications. Central nervous system (CNS) leukemia is an uncommon complication of CMLblastic crisis (1 , 2), but infections and hemorrhage in the CNSare a frequent cause of death (3). The present report describes a patient with CMLblastic crisis, which was in remission, whodeveloped severe herpes simplex meningoencephalitis complicated by superior sagittal sinus thrombosis.…”