Durability of Benefits From Supervised Treadmill Exercise in People With Peripheral Artery Disease

McDermott, Mary McGrae; Kibbe, Melina R.; Guralnik, Jack M.; Ferrucci, Luigi; Criqui, Michael H.; Domanchuk, Kathryn; Tian, Lü; Zhao, Lihui; Li, Lingyu; Patel, Kruti; Polonsky, Tamar S.

doi:10.1161/jaha.118.009380

Cited by 29 publications

(28 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The functional status of the patients was measured using the WIQ, which has been validated as a measure of perceived difficulty concerning walking distances and speeds and the ability to climb stairs [39]; significant improvements were seen in walking distance but benefits regarding walking speed and stair-climbing ability were not observed. These results are similar to those of other exercise intervention studies, which reported significant effects on WIQ walking distance and no effects on other outcome measures [40,41].…”

Section: Principal Findingssupporting

confidence: 89%

Effectiveness of Mobile Health–Based Exercise Interventions for Patients with Peripheral Artery Disease: Systematic Review and Meta-Analysis

Kim

et al. 2021

JMIR Mhealth Uhealth

View full text Add to dashboard Cite

Background Peripheral artery disease (PAD) affects over 236 million people worldwide, and exercise interventions are commonly used to alleviate symptoms of this condition. However, no previous systematic review has evaluated the effects of mobile health (mHealth)–based exercise interventions for patients with PAD. Objective This study aimed to assess the effect of mHealth-based exercise interventions on walking performance, functional status, and quality of life in patients with PAD. Methods A systematic review and meta-analysis were conducted. We searched in seven databases to identify randomized controlled trials of patients with PAD published in English up to December 4, 2020. Studies were included if patients participated in mHealth-based exercise interventions and were assessed for walking performance. We analyzed pooled effect size on walking performance, functional status, and quality of life based on the standardized mean differences between groups. Results A total of seven studies were selected for the systematic review, and six studies were included in the meta-analysis. The duration of interventions in the included studies was 12 to 48 weeks. In the pooled analysis, when compared with the control groups, the mHealth-based exercise intervention groups were associated with significant improvements in pain-free walking (95% CI 0.13-0.88), maximal walking (95% CI 0.03-0.87), 6-minute walk test (6MWT) distance (95% CI 0.59-1.24), and walking distance (95% CI 0.02-0.49). However, benefits of the interventions on walking speed, stair-climbing ability, and quality of life were not observed. Conclusions mHealth-based exercise interventions for patients with PAD were beneficial for improving pain-free walking, maximal walking, and 6MWT distance. We found that exercise interventions using mHealth are an important strategy for improving the exercise effectiveness and adherence rate of patients with PAD. Future studies should consider the use of various and suitable functions of mHealth that can increase the adherence rates and improve the effectiveness of exercise.

show abstract

Section: Principal Findingssupporting

confidence: 89%

Effectiveness of Mobile Health–Based Exercise Interventions for Patients with Peripheral Artery Disease: Systematic Review and Meta-Analysis

Kim

et al. 2021

JMIR Mhealth Uhealth

View full text Add to dashboard Cite

show abstract

“…In a randomised study, 156 participants were allocated to supervised treadmill exercise, supervised resistance training, or oral advice about nutrition and training. (35) After 6 months, the 6 minute walk distance improved only in the treadmill exercise group (36.1 m, 95% CI 13.9 -58.3), but at 12 months neither treadmill nor resistance significantly differed from baseline or control (walking distance: +7.5m and +6.1m).…”

Section: Proximal Aortic Longitudinal Strainmentioning

confidence: 86%

The year in cardiology: aorta and peripheral circulation

Heiß

Pitcher

Belch

et al. 2020

SAHJ

View full text Add to dashboard Cite

to qualify atherosclerotic disease of the lower extremity arteries and carotid arteries. In the current article and in line with the European Society of Cardiology (ESC) guidelines, (4) we have stringently used the specific terms lower extremity arterial disease (LEAD) and have reserved PAD as the umbrella term encompassing all arterial diseases other than relating to the aorta and coronaries. VASCULAR BIOLOGY/TRANSLATIONAL RESEARCHThe extent to which genetic factors contribute to PAD development and if they are shared or distinct between LEAD, cerebral, and coronary arteries are largely unknown. In a genome-wide association study in the Million Veteran Program, ~32 million DNA sequence variants were tested for PAD (31 307 cases, 211 753 controls) and combined with electronic health records. (5) The results were replicated in an independent sample from the UK Biobank. They identified 19 LEAD loci (18 not previously reported): 11 loci were associated with disease in 3 vascular beds (coronary, cerebral, and lower extremity), including LDLR, LPL, and Lp(a) (Figure 1); 4 loci appeared to be specific for LEAD, including F5 p.R506Q (Factor V Leiden variant), highlighting the pathogenic role of thrombosis in LEAD and supporting Factor Xa inhibition as a therapeutic strategy.Despite the fact that numerous long non-coding RNAs (lncRNA) have been identified, only a few of them have been studied with respect to endothelial cell homeostasis or vascular disease development. One of them, the pro-angiogenic lncRNA MANTIS, may be clinically relevant in carotid disease. (6) In fact, the protective effects of laminar flow and statins are, at least in part, attributed to the expression of MANTIS. The mechanisms involve epigenetic rearrangements and the transcription factors Krüppel-like factor 2 and 4. As induction of MANTIS mimics the beneficial effects of statins on endothelial function, the authors proposed that strategies to increase MANTIS might improve vascular function in patients not responding to statin therapy.

show abstract

“…In addition to reducing the strength of the lower limb muscles [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ], chronic lower limb ischemia also changes the gait pattern. Compared to a group of healthy individuals, people with PAD exhibit an extended stance phase while simultaneously shortening the swing phase [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

“…The primary aims of physical rehabilitation are to extend the walking distance until claudication onset and to reduce pain, which can be achieved through regular physical training [ 12 ]. Treadmill training is the current gold standard for rehabilitation; however, researchers have observed a non-physiological gait pattern in people with PAD due to their fear of falling [ 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Physical Rehabilitation on Spatiotemporal Gait Parameters and Ground Reaction Forces of Patients with Intermittent Claudication

Dziubek

Stefańska

Bulińska

et al. 2020

JCM

View full text Add to dashboard Cite

Chronic ischemia of the lower extremities often presents as intermittent claudication characterized by lower limb pain which subsides after a short break. This study aimed to provide an assessment of the spatiotemporal parameters of gait and ground reaction forces in patients with PAD participating in three forms of supervised physical training. A total of 80 subjects completed a three-month supervised physical rehabilitation program with three sessions per week. The subjects were assigned to one of three programs: group 1—standard walking training on a treadmill (TT); group 2—Nordic walking (NW) training; group 3—strength and endurance training comprised of NW with isokinetic resistance training (NW + ISO). Gait biomechanics tests (kinematic and kinetic parameters of gait) and a six-minute walk test were carried out before and after three months of physical training. Nordic walking training led to the greatest improvements in the gait pattern of patients with PAD and a significant increase in the absolute claudication distance and total gait distance. Combined training (NW + ISO) by strengthening the muscles of the lower extremities increased the amplitude of the general center of gravity oscillation to the greatest extent. Treadmill training had little effect on the gait pattern. Nordic walking training should be included in the rehabilitation of patients with PAD as a form of gait training, which can be conducted under supervised or unsupervised conditions.

show abstract

Durability of Benefits From Supervised Treadmill Exercise in People With Peripheral Artery Disease

Cited by 29 publications

References 30 publications

Effectiveness of Mobile Health–Based Exercise Interventions for Patients with Peripheral Artery Disease: Systematic Review and Meta-Analysis

Effectiveness of Mobile Health–Based Exercise Interventions for Patients with Peripheral Artery Disease: Systematic Review and Meta-Analysis

The year in cardiology: aorta and peripheral circulation

Effects of Physical Rehabilitation on Spatiotemporal Gait Parameters and Ground Reaction Forces of Patients with Intermittent Claudication

Contact Info

Product

Resources

About