Duplication of the mitochondrial control region is associated with increased longevity in birds

Skujina, Ilze; McMahon, Robert; Lenis, Vasilis; Gkoutos, Georgios V.; Hegarty, Matthew J.

doi:10.18632/aging.101012

Cited by 25 publications

(26 citation statements)

References 30 publications

(37 reference statements)

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“…The second is the presence of a duplication and degeneration of the entire control region that appears to have fixed across Falco species. Similar duplications have been reported as evolutionary parallelism in other birds and squamates and have been suggested to have functional potential (Skujina, McMahon, Lenis, Gkoutos, & Hegarty, ). Mitochondrial heteroplasmy has also been reported in some falcons (Fuchs et al, ), although its prevalence and significance have not been assessed.…”

Section: The Biology Of Falconssupporting

confidence: 78%

Falcon genomics in the context of conservation, speciation, and human culture

Wilcox

Boissinot

Idaghdour

2019

Ecology and Evolution

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Here, we review the diversity, evolutionary history, and genomics of falcons in the context of their conservation and interactions with humans, and provide a perspective on how new genomic approaches may be applied to expand our knowledge of these topics. For millennia, humans and falcons (genus Falco) have developed unique relationships through falconry, religious rituals, conservation efforts, and human lifestyle transitions. From an evolutionary perspective, falcons remain an enigma. Having experienced several recent radiations, they have reached an unparalleled and almost global distribution, with an intrageneric species richness that is roughly an order of magnitude higher than typical within their family (Falconidae) and across other birds (Phylum: Aves). This diversity has evolved in the context of unusual genomic architecture that includes unique chromosomal rearrangements, relatively low chromosome counts, extremely low microdeletion rates, and high levels of nuclear mitochondrial DNA segments (NUMTs). These genomic peculiarities combine with high levels of ecological and organismal diversity and a legacy of human interactions to make falcons obvious candidates for evolutionary studies, providing unique research opportunities in common topics, including chromosomal evolution, the mechanics of speciation, local adaptation, domestication, and urban adaptation.

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Section: The Biology Of Falconssupporting

confidence: 78%

Falcon genomics in the context of conservation, speciation, and human culture

Wilcox

Boissinot

Idaghdour

2019

Ecology and Evolution

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“…However, it may be a consequence of larger body size because body mass is positively correlated with longevity in homeothermic animals, including birds ( Lindstedt and Calder 1976 , 1981 ; Hulbert et al. 2007 ; Skujina et al. 2016 ).…”

Section: Resultsmentioning

confidence: 99%

“…The new data helped to elucidate the evolution of the parrot mitogenome in terms of duplications. As mitochondrial duplication can be associated with many phenomena, for example, greater longevity ( Skujina et al. 2016 ) and stronger compositional asymmetry between DNA strands ( Eberhard and Wright 2016 ), we also studied relationships of the mitogenomic duplications with the DNA asymmetry and life span as well as basic morphological characteristics of parrots.…”

Section: Introductionmentioning

confidence: 99%

New insight into parrots’ mitogenomes indicates that their ancestor contained a duplicated region

Urantowka

Kroczak

Silva³

et al. 2018

Molecular Biology and Evolution

104

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Mitochondrial genomes of vertebrates are generally thought to evolve under strong selection for size reduction and gene order conservation. Therefore, a growing number of mitogenomes with duplicated regions changes our view on the genome evolution. Among Aves, order Psittaciformes (parrots) is especially noteworthy because of its large morphological, ecological, and taxonomical diversity, which offers an opportunity to study genome evolution in various aspects. Former analyses showed that tandem duplications comprising the control region with adjacent genes are restricted to several lineages in which the duplication occurred independently. However, using an appropriate polymerase chain reaction strategy, we demonstrate that early diverged parrot groups contain mitogenomes with the duplicated region. These findings together with mapping duplication data from other mitogenomes onto parrot phylogeny indicate that the duplication was an ancestral state for Psittaciformes. The state was inherited by main parrot groups and was lost several times in some lineages. The duplicated regions were subjected to concerted evolution with a frequency higher than the rate of speciation. The duplicated control regions may provide a selective advantage due to a more efficient initiation of replication or transcription and a larger number of replicating genomes per organelle, which may lead to a more effective energy production by mitochondria. The mitogenomic duplications were associated with phenotypic features and parrots with the duplicated region can live longer, show larger body mass as well as predispositions to a more active flight. The results have wider implications on the presence of duplications and their evolution in mitogenomes of other avian groups.

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“…Based on studies in mammals and fruit flies, it has been proposed that mt genomes with duplicated CR may have a selective advantage over mt genomes with a single CR, by allowing a higher replication rate (Shao et al, 2005). Moreover, in some avian families, it was demonstrated that duplication of the CR forms a pseudo-CR which is associated with extended lifespan (Skujina et al, 2016). It is unclear whether any of these potential advantages may apply to G. roeselii and this issue represents an interesting avenue for future research in G. roeselii mitochondrial biology and, more generally, to further investigate the evolutionary forces at work and implications of CR duplications in animal mt genomes.…”

Section: Discussionmentioning

confidence: 99%