Duodenal Obstruction as First Presentation of Metastatic Breast Cancer

Khairy, Sami; Azzam, Ayman; Mohammed, Shamayel; Suleman, Kausar; Khawaji, Abdurahman; Amin, Tarek

doi:10.1155/2015/605719

Cited by 7 publications

(3 citation statements)

References 9 publications

(8 reference statements)

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“…Also, as presented here, GIT metastases from ILC often occur many years after the diagnosis of the primary tumor, leading clinicians not to consider the possibility of recurrence. The disease-free interval between primary breast cancer and GIT metastases may range from synchronous to as long as 30 years, and occasionally the GIT manifestation precedes the diagnosis of breast cancer [3, 14]. An additional challenge in our case was the low sensitivity of preoperative imaging to pick up additional metastatic sites and the limitation of endoscopy in providing diagnosis given that the disease was beyond the mucosa.…”

Section: Discussion/conclusionmentioning

confidence: 99%

“…A high level of suspicion for metastases should be maintained when patients with a history of lobular breast cancer present with GI symptoms, or with a presumed new primary tumor or stricture of the GIT. Furthermore, given the prevalence of breast cancer and the fact that the presenting symptoms of GI metastasis from breast cancer are usually not specific to the origin and mimic a primary intestinal disorder [14], health-care professionals beyond oncologists, especially gastroenterologists and PCPs, may such encounter patients. Also, the central role of endoscopy and biopsy in ascertaining the diagnosis of such patients additionally highlights the importance of awareness of this presentation by gastroenterologists.…”

Section: Discussion/conclusionmentioning

confidence: 99%

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Duodenal and Biliary Obstruction due to Extrinsic Compression by Recurrent Lobular Breast Carcinoma: A Case Report

Hamidu

Asif

Lavu

et al. 2021

Case Rep Gastroenterol

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Metastases to the gastrointestinal tract (GIT) from breast carcinoma are rare, detected in approximately <5% of all breast cancer patients. Invasive lobular carcinoma (ILC) is the most common histological type of breast cancer to metastasize to the GIT. We report a case of abdominal recurrence of ILC of the breast causing intra-abdominal contracture leading to extrinsic compression of the duodenum and periampullary biliary tree. Four years after the patient’s diagnosis of a left breast pT1c, pN2, cM0 invasive lobular breast cancer, she presented with liver function tests consistent with biliary obstruction, and there was concern for a periampullary malignancy. Definitive diagnosis was achieved at laparotomy. This case demonstrates the importance of considering metastatic breast cancer as a potential cause of GI symptoms and radiological abnormalities affecting any part of the GIT of women with a previous history of lobular breast cancer. This case also highlights the effectiveness of chemotherapy in improving the survival and quality of life of these patients. Early recognition of this scenario enables prompt initiation of systemic therapy and avoids unnecessary surgical treatment. Despite the rarity, such patients will be encountered in clinical practice given the high prevalence of breast cancer. Moreover, the fact that the presenting symptoms of GI metastasis from breast cancer are usually not specific to the origin and mimic a primary intestinal disorder, health-care professionals beyond oncologists, especially gastroenterologists and primary care physicians, should be aware of this entity.

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Section: Discussion/conclusionmentioning

confidence: 99%

Section: Discussion/conclusionmentioning

confidence: 99%

Duodenal and Biliary Obstruction due to Extrinsic Compression by Recurrent Lobular Breast Carcinoma: A Case Report

Hamidu

Asif

Lavu

et al. 2021

Case Rep Gastroenterol

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“…Khairy et al describen el caso de una paciente que presentó obstrucción duodenal como manifestación inicial de un cáncer de mama metastásico. 5 Frase-Moodie et al reportan en el año 1974 el caso de una paciente, con diagnóstico de cáncer de mama, que presentó 13 años después una metástasis en yeyuno, que fue tratada quirúrgicamente con una evolución favorable, 6 y un caso similar con metástasis ileal fue asimismo descripto. 8 Otros reportes demuestran el compromiso duodenal en el contexto de una enfermedad metastásica avanzada con pobre respuesta al tratamiento paliativo.…”

Section: Discussionunclassified

Metástasis duodenal de cáncer de mama. Presentación atípica y resolución quirúrgica no habitual

Jaramillo¹,

Ojeda²,

T³

et al. 2020

Acta gastroenterol. latinoam.

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Breast cancer is the most frequent malignant tumor and the leading cause of death worldwide. The most frequent sites of metastatic involvement are the bone, liver and lung, and less than 1% compromise the gastrointestinal tract. The case of a patient with a history of breast cancer treated with chemotherapy and subsequent duodenal relapse is presented below. A cephalic duodenopancreatectomy (CDP) and adjuvant chemotherapy were performed with favorable evolution.

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A case of rare gastric metastasis of invasive lobular carcinoma of the breast

Liang

Paredes

Karpes

et al. 2023

Journal of Surgical Case Reports

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Breast cancer is the most common type of cancer diagnosed among women worldwide. It significantly contributes to cancer-related mortality in females. Early-stage breast cancers have a high cure rate. However, distant metastasis of breast cancer due to haematological and lymphatic spread often leads to a poor prognosis. Gastric and duodenal metastasises are rarely observed in invasive lobular carcinoma of the breast. Early diagnosis is challenging due to the non-specific symptoms, the limited specificity of radiological investigations and the difficulty in obtaining adequate tissue biopsy. Herein, we report the clinical, radiological, and macroscopic features of a 72-year-old female with rare gastric metastasis of breast cancer and likely concurrent duodenal metastasis.

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Duodenal Obstruction as First Presentation of Metastatic Breast Cancer

Cited by 7 publications

References 9 publications

Duodenal and Biliary Obstruction due to Extrinsic Compression by Recurrent Lobular Breast Carcinoma: A Case Report

Duodenal and Biliary Obstruction due to Extrinsic Compression by Recurrent Lobular Breast Carcinoma: A Case Report

Metástasis duodenal de cáncer de mama. Presentación atípica y resolución quirúrgica no habitual

A case of rare gastric metastasis of invasive lobular carcinoma of the breast

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