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Cited by 59 publications
(43 citation statements)
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References 22 publications
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“…Moreover, our recent data showed an abundant eosinophil iniltration in the rectal mucosa of most patients with NCWS, revealing that rectal inlammation is also a characteristic of NCWS [11]. Consequently, the anatomic proximity between an "inlamed" rectum and other pelvic organs could be the pathogenetic explanation for the high frequency of urogenital disturbances in NCWS, this "speciic subgroup" of IBS patients.…”
Section: Discussionmentioning
confidence: 87%
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“…Moreover, our recent data showed an abundant eosinophil iniltration in the rectal mucosa of most patients with NCWS, revealing that rectal inlammation is also a characteristic of NCWS [11]. Consequently, the anatomic proximity between an "inlamed" rectum and other pelvic organs could be the pathogenetic explanation for the high frequency of urogenital disturbances in NCWS, this "speciic subgroup" of IBS patients.…”
Section: Discussionmentioning
confidence: 87%
“…As the irst step of evaluation, CD and WA diagnoses were ruled out in all the 68 study patients according to the following criteria: (1) negative serum assays for CD, anti-tissue transglutaminase (anti-tTG) IgA and anti-deamidated gliadin peptide (anti-DGP) IgG antibodies; (2) the absence of intestinal villous atrophy, documented in all the patients carrying the DQ2 and/or DQ8 HLA haplotypes; and (3) negative IgE-mediated immune-allergy tests to wheat (skin prick tests and/or speciic serum IgE testing). Inlammatory bowel diseases and other diagnoses were also excluded in accordance with current recommendations, as previously described [10,11].…”
Section: Non-celiac Wheat Sensitivity Diagnosismentioning
confidence: 99%
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“…Furthermore, an increased number of degranulated eosinophils in the duodenum has been identified as hallmark of FD . Moreover, Carroccio et al investigated in detail the histologic characteristics of duodenal mucosa in 78 NCG/WS patients, 39 non‐NCG/WS patients, and 16 CD enrolled as positive control group. Interestingly, the duodenal mucosal biopsies of NCG/WS had a significantly higher number of intraepithelial CD3 + T cells, lamina propria CD45 + immunocytes, and eosinophils compared to non‐NCG/WS controls.…”
Section: Discussionmentioning
confidence: 99%
“…However, it was pointed out that AGA probably develop in a majority of patients with an altered (increased) gut permeability without any disease specificity, thus this finding has to be considered with caution [19]. Other markers tested are in vitro basophil activation test in response to food antigens [20] or the number of eosinophils in the intestinal mucosa [21]. However, neither test reached a high level of specificity, making them not usable in a routine clinical setting.…”
Section: Clinical Presentation and Diagnosis Of Ncgsmentioning
confidence: 99%