Duffy blood group system and the malaria adaptation process in humans

Carvalho, Gledson Barbosa de; Carvalho, Glauber Barbosa de

doi:10.5581/v33n1a16

Cited by 24 publications

(5 citation statements)

References 85 publications

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“…The Duffy blood group locus is located on the long arm of chromosome 1 (1.q22-1.q23) and consists of three major alleles: FY*A (encoding the Fy a ), FY*B (encoding the Fy b ), and FY*B ES (4,5). The FY*A and FY*B alleles differ by a single nucleotide polymorphism (SNP) at nucleotide 125 (G125A, rs12075) resulting in the amino acid change Gly42Asp (6). FY*B ES whose homozygote corresponds to the Fy (a-b-) phenotype is caused by a SNP from T to C at position-33 in the GATA box motif of the FY*B promoter.…”

Section: Introductionmentioning

confidence: 99%

A New Method for Analyzing the Duffy Blood Group Genotype by TaqMan Minor Groove Binding Probes

Zhou

Liu

An³

et al. 2014

Clinical Laboratory Analysis

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Section: Introductionmentioning

confidence: 99%

A New Method for Analyzing the Duffy Blood Group Genotype by TaqMan Minor Groove Binding Probes

Zhou

Liu

An³

et al. 2014

Clinical Laboratory Analysis

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“…Our analysis of potential chemokine receptor-ligand interactions in the TME of PCa revealed CXCR4 and ACKR1 as the main receivers of CXC-signaling of which only ACKR1 is known to bind the CXCchemokines of our signatures. ACKR1, also known as the Duffy antigen receptor, was initially discovered on erythrocytes and loss of expression is associated with malaria resistance [55]. Apart from erythrocytes, ACKR1 is expressed on endothelial cells of the lungs.…”

Section: Discussionmentioning

confidence: 99%

“…ACKR1, also known as the Duffy antigen receptor, was initially discovered on erythrocytes and loss of expression is associated with malaria resistance [34]. Apart from erythrocytes, ACKR1 is expressed on endothelial cells of the lungs.…”

Section: Chemokine Receptor Ackr1 Dominant Receptor Of Cxc-chemokines...mentioning

confidence: 99%

Deep phenotyping of the prostate tumor microenvironment reveals molecular stratifiers of relapse linked to inflammatory chemokine expression and aberrant metabolism

Krossa,

Andersen,

Midtbust

et al. 2024

Preprint

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Understanding the molecular characteristics and changes of the tumor microenvironment (TME) associated with aggressive prostate cancer (PCa) is essential for precise diagnosis and treatment. We interrogated spatially resolved integrated transcriptomics and metabolomics data to build molecular signatures capable of discriminating patients with aggressive, potentially relapsing, and metastasizing PCa. We report two signatures characterized by upregulated expression of immune response related genes with increased activity in relapsing patients. The signatureRelapsewas active in cancer, stroma, and glandular tissue while the other was a feature of morphologically normal appearing glands (NAG) adjacent to aggressive cancer and was named the NAG signature. The NAG signature scored high in regions with upregulated expression of pro-inflammatory chemokines and in glandular regions enriched with Club-like cells and immune cell infiltration in the surrounding stroma. Regions which scored high for both NAG and relapse were associated with loss of normal prostate secretory gland functions such as reduced expression of genes necessary for citrate secretion and reduced levels of citrate and zinc. Our findings suggest that aggressive PCa is associated with an increased inflammatory status linked to chemokine production and Club-like cells.

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“…The Duffy antigen receptor for chemokines (DARC) is encoded by the DARC gene expressed on the surface of red blood cells (RBCs) and plays a role in RBC invasion by the P. vivax parasite [ 16 , 17 ]. Individuals who lack Duffy antigen expression (Duffy-negative individuals) are known to be resistant to P. vivax [ 18 , 19 ] and have a reduced risk of P. vivax infection [ 20 , 21 ]. However, Duffy negativity does not provide complete protection against vivax malaria [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Detection of Duffy blood group genotypes and submicroscopic Plasmodium infections using molecular diagnostic assays in febrile malaria patients

Abagero,

Rama,

Obeid

et al. 2024

Malar J

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Background Malaria remains a severe parasitic disease, posing a significant threat to public health and hindering economic development in sub-Saharan Africa. Ethiopia, a malaria endemic country, is facing a resurgence of the disease with a steadily rising incidence. Conventional diagnostic methods, such as microscopy, have become less effective due to low parasite density, particularly among Duffy-negative human populations in Africa. To develop comprehensive control strategies, it is crucial to generate data on the distribution and clinical occurrence of Plasmodium vivax and Plasmodium falciparum infections in regions where the disease is prevalent. This study assessed Plasmodium infections and Duffy antigen genotypes in febrile patients in Ethiopia. Methods Three hundred febrile patients visiting four health facilities in Jimma town of southwestern Ethiopia were randomly selected during the malaria transmission season (Apr–Oct). Sociodemographic information was collected, and microscopic examination was performed for all study participants. Plasmodium species and parasitaemia as well as the Duffy genotype were assessed by quantitative polymerase chain reaction (qPCR) for all samples. Data were analysed using Fisher’s exact test and kappa statistics. Results The Plasmodium infection rate by qPCR was 16% (48/300) among febrile patients, of which 19 (39.6%) were P. vivax, 25 (52.1%) were P. falciparum, and 4 (8.3%) were mixed (P. vivax and P. falciparum) infections. Among the 48 qPCR-positive samples, 39 (13%) were negative by microscopy. The results of bivariate logistic regression analysis showed that agriculture-related occupation, relapse and recurrence were significantly associated with Plasmodium infection (P < 0.001). Of the 300 febrile patients, 85 (28.3%) were Duffy negative, of whom two had P. vivax, six had P. falciparum, and one had mixed infections. Except for one patient with P. falciparum infection, Plasmodium infections in Duffy-negative individuals were all submicroscopic with low parasitaemia. Conclusions The present study revealed a high prevalence of submicroscopic malaria infections. Plasmodium vivax infections in Duffy-negative individuals were not detected due to low parasitaemia. In this study, an improved molecular diagnostic tool was used to detect and characterize Plasmodium infections, with the goal of quantifying P. vivax infection in Duffy-negative individuals. Advanced molecular diagnostic techniques, such as multiplex real-time PCR, loop-mediated isothermal amplification (LAMP), and CRISPR-based diagnostic methods. These techniques offer increased sensitivity, specificity, and the ability to detect low-parasite-density infections compared to the employed methodologies.

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Duffy blood group system and the malaria adaptation process in humans

Cited by 24 publications

References 85 publications

A New Method for Analyzing the Duffy Blood Group Genotype by TaqMan Minor Groove Binding Probes

A New Method for Analyzing the Duffy Blood Group Genotype by TaqMan Minor Groove Binding Probes

Deep phenotyping of the prostate tumor microenvironment reveals molecular stratifiers of relapse linked to inflammatory chemokine expression and aberrant metabolism

Detection of Duffy blood group genotypes and submicroscopic Plasmodium infections using molecular diagnostic assays in febrile malaria patients

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