Ductal Lavage of Cancerous and Unaffected Breasts

Wood, Marie; Stanley, Mary; Crocker, Abigail; Kingsley, F; Leiman, Gladwyn

doi:10.1159/000325341

Cited by 5 publications

(2 citation statements)

References 27 publications

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“…However, Wood et al found that nipple aspiration fluid was more commonly expressed in cancerous, as compared with unaffected, breasts. Overall, sensitivity for detecting marked atypia or malignant cells in affected breasts was 17 %, which is comparable to the results in other studies [37]. …”

Section: Ductal Lavage (Dl)supporting

confidence: 87%

Comparison of Random Periareolar Fine Needle Aspirate versus Ductal Lavage for Risk Assessment and Prevention of Breast Cancer

Hoffman

Pellenberg

Drendall

et al. 2012

Curr Breast Cancer Rep

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Random periareolar fine needle aspiration (RPFNA) and ductal lavage (DL) are research techniques developed to (1) assess short-term breast cancer risk in asymptomatic women who are at increased risk for breast cancer and (2) track cytological response to risk reduction strategies. RPFNA and DL provide minimally invasive methods to repeatedly sample epithelial cells and research tools to investigate the biological origins of breast cancer in high-risk women. This review gives an overview of the strengths and limitations of both RPFNA and DL for risk assessment and breast cancer prevention in asymptomatic high-risk women.

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Section: Ductal Lavage (Dl)supporting

confidence: 87%

Comparison of Random Periareolar Fine Needle Aspirate versus Ductal Lavage for Risk Assessment and Prevention of Breast Cancer

Hoffman

Pellenberg

Drendall

et al. 2012

Curr Breast Cancer Rep

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show abstract

“…Brogi et al [25] showed a similar sensitivity of 14% in their study of premastectomy ductal lavage on 26 cancer-containing breasts. Although a recent study by Wood et al [26] found that nipple aspiration fluid was more commonly expressed in cancerous compared with unaffected breasts, overall sensitivity for detecting marked atypia or malignant cells in affected breasts was similar to previous studies, at approximately 17%.…”

Section: Intraductal Lavagesupporting

confidence: 67%

Status of Intraductal Therapy for Ductal Carcinoma in Situ

Flanagan

Love

Hwang

2010

Curr Breast Cancer Rep

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The intraductal approach is particularly appealing in the setting of ductal carcinoma in situ (DCIS), a preinvasive breast neoplasm that is thought to be entirely intraductal in its extent. Based on an emerging understanding of the anatomy of the ductal system as well as novel techniques to leverage the access accorded by the intraductal approach, researchers are actively exploring how ductal lavage, ductoscopy, and intraductal infusion of therapeutic agents may enhance breast cancer treatment. Both cytologic and molecular diagnostics continue to improve, and work is ongoing to identify the most effective diagnostic biomarkers for DCIS and cancer, although optimal targeting of the diseased duct remains an important consideration. Ductoscopy holds potential in detection of occult intraductal lesions, and ductoscopically guided lumpectomy could increase the likelihood of a more comprehensive surgical excision. Exciting pilot studies are in progress to determine the safety and feasibility of intraductal chemotherapy infusion. These studies are an important starting point for future investigations of intraductal ablative therapy for DCIS, because as our knowledge and techniques evolve, it is likely that DCIS may be the target most amenable to treatment by intraductal therapy. If such studies are successful, these approaches will allow an important and meaningful transformation in treatment options for women diagnosed with DCIS.

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Current and Future Direction in Basic and Translational Research

Love

2012

Management of the Patient at High Risk for Breast Cancer

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Ductal Lavage of Cancerous and Unaffected Breasts

Cited by 5 publications

References 27 publications

Comparison of Random Periareolar Fine Needle Aspirate versus Ductal Lavage for Risk Assessment and Prevention of Breast Cancer

Comparison of Random Periareolar Fine Needle Aspirate versus Ductal Lavage for Risk Assessment and Prevention of Breast Cancer

Status of Intraductal Therapy for Ductal Carcinoma in Situ

Current and Future Direction in Basic and Translational Research

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