Ductal carcinoma of male breast with prominent lipid-rich component

Mazzella, Fermina M.; Sieber, Steven; Braza, Frank

doi:10.1080/00313029500169123

Cited by 31 publications

(49 citation statements)

References 5 publications

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“…3,6,8 In the veterinary literature, lipid-rich carcinoma of the mammary gland has been reported in a total of 10 dogs but has not been reported previously in cats. 1,6 The World Health Organization (WHO) tumor classification system indicates that lipid-rich carcinomas of the canine mammary gland are extremely uncommon; however, it does not identify this tumor type as a variant of feline mammary tumors.…”

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Lipid-rich Carcinoma of the Mammary Gland in a Cat

Kamstock¹,

Fredrickson²,

Ehrhart³

2005

Vet Pathol

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Abstract. A 1.5-year-old female, intact, clinically healthy cat presented for a subcutaneous mass of the ventral abdomen. Surgical excision and microscopic examination of the mass were performed. Histologically, this was a discrete, unencapsulated, multilobular, expansile mass, which compressed the surrounding normal mammary tissue. Lobules were composed of tubuloacinar structures formed by atypical round to polygonal cells, which contained foamy to microvacuolated cytoplasm and variably sized, intracytoplasmic, distinct vacuoles causing nuclear peripheralization. Neoplastic cells demonstrated intense and diffuse immunoreactivity for cytokeratin and lacked immunoreactivity for vimentin. The vacuolar contents stained positively with Oil Red-O and negatively with periodic acid-Schiff and Alcian blue stains. Histomorphologic, histochemical, and immunohistochemial analysis support a diagnosis of lipid-rich mammary carcinoma. This is the first report of a cat with a lipid-rich variant of mammary carcinoma.Key words: Carcinoma; felines; immunohistochemistry; lipid-rich; mammary gland; Oil Red-O.Lipid-rich mammary carcinoma, although exceedingly rare, occurs in women and has been reported in the breast of a single male. 3,6,8 In the veterinary literature, lipid-rich carcinoma of the mammary gland has been reported in a total of 10 dogs but has not been reported previously in cats. 1,6 The World Health Organization (WHO) tumor classification system indicates that lipid-rich carcinomas of the canine mammary gland are extremely uncommon; however, it does not identify this tumor type as a variant of feline mammary tumors. 5 This is the first report of a lipid-rich mammary gland carcinoma in a cat.A 1.5-year-old female, intact, calico, outdoor, farm cat presented for a single mass on the ventral abdomen, which had been present for an unknown period of time. Physical exam revealed a 2.5-cm-diameter (additional dimensions were not provided) subcutaneous mass of the left, fourth mammary gland, which was mottled white to bluish-black, lobular, moderately firm, and nonpainful on palpation. No additional masses were noted, and no lymphadenomegaly was identified. Other than the presence of a mild flea infestation, remaining physical exam findings were unremarkable. Routine blood work was within normal limits, and radiographs were not pursued.The animal was taken to surgery for mass removal and ovariohysterectomy (OHE). The mass was submitted to the Veterinary Diagnostic Laboratory, University of Illinois, for routine histopathologic examination. Expanding the dermis, compressing surrounding mammary glands and ducts, and elevating the overlying epidermis was an unencapsulated, discrete, multilobulated mass. Lobules were separated by dense bands of fibrovascular connective tissue and composed of closely packed, variably sized (10-40 m diameter), round to polygonal cells. These cells frequently formed tubuloacinar structures (up to four cell layers thick) of variable luminal diameter. Individual cells contained moderate to abundant, ...

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Lipid-rich Carcinoma of the Mammary Gland in a Cat

Kamstock¹,

Fredrickson²,

Ehrhart³

2005

Vet Pathol

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“…It has been described in 15 cases so far in the English-language literature, either as a minor or predominant component in a classical ductal carcinoma or as a pure line of differentiation [1][2][3][4][5][6][7][8][9][10][11]. According to the current WHO classification, primary sebaceous carcinoma of the breast must show sebaceous differentiation in at least 50% of cells and have no evidence of origin from the cutaneous adnexa [12].…”

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confidence: 99%

Original paper Sebaceous carcinoma of the breast: report of four cases and review of the literature

Švajdler¹,

Baník²,

Poliaková³

et al. 2015

pjp

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“…10 Mammary tumors also may occur in both male and female Djungarian hamsters, 7,8 although the present lipid-rich carcinoma occurred in a female. All reported lipid-rich carcinomas in the dog and cat also have been described solely in females.…”

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Lipid-Rich Carcinoma in the Mammary Gland of a Djungarian Hamster (Phodopus Sungorus)

et al. 2010

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Abstract. A lipid-rich carcinoma of the mammary gland was diagnosed in a female Djungarian hamster (Phodopus sungorus), which was kept as an indoor pet. The animal underwent surgery for a primary tumor arising in the mammary gland at the age of 16 months, and also for a recurrent tumor 6 months later. Histologically, the primary neoplasm was composed of 2 different cell populations: nonvacuolated glandular neoplastic cells with moderate atypia, and vacuolated neoplastic cells with marked atypia. Transition from the nonvacuolated glandular cells to the vacuolated cells was frequently seen. The recurrent neoplasm was composed predominantly of vacuolated neoplastic cells that often invaded the surrounding soft tissue. The cytoplasmic vacuoles contained neutral lipids, as confirmed by oil red O and Nile blue staining. The vacuolated neoplastic cells were immunopositive for cytokeratin and negative for vimentin, a-smooth muscle actin, p63, estrogen receptor a, and androgen receptor. Presumably, this high-grade, lipid-rich mammary carcinoma had developed from a low-grade mammary adenocarcinoma.Key words: Djungarian hamster; immunohistochemistry; lipid-rich carcinoma; mammary tumor; Phodopus sungorus.In human medicine, lipid-rich carcinoma is a rare variant of invasive breast carcinoma in which tumor cells contain abundant cytoplasmic neutral lipids. 4,16 The morphological features of this neoplasm were first described in a human patient in 1963.1 However, because of the great rarity of this neoplasm, many aspects of its pathology remain to be elucidated. In the veterinary literature, lipid-rich mammary carcinoma has been recognized as a rare neoplasm in 12 female dogs 5,11-13 and 1 female cat. The Djungarian hamster (Phodopus sungorus), also known as the Dzhungarian hamster, Siberian dwarf hamster, or Russian dwarf hamster, is a popular, indoor small pet in Japan. This species is also used as a laboratory animal, although it is used less often than the Syrian hamster (Mesocricetus auratus). In Djungarian hamsters, mammary tumor is one of the most common spontaneous neoplasms, 3,7,8,14,18 and androgen-dependent atypical fibromas are likewise known to arise in the skin with aging. 2 A female Djungarian hamster, which weighed 52 g at the age of 16 months and was kept as an indoor pet, developed a subcutaneous mass at the site of the fourth mammary gland on the left side. At 9 months of age, this hamster had undergone surgery to excise a neoplasm in the first left mammary gland. This neoplasm had been diagnosed as an adenocarcinoma. The present mass in the fourth left mammary gland (the primary tumor) was surgically excised. It measured 2.0 cm 3 1.5 cm 3 1.5 cm and weighed 1.7 g. When the animal was 22 months old and weighed 53 g, the neoplasm in the fourth left mammary gland recurred and was surgically excised again. This mass measured 2.2 cm 3 2.0 cm 3 1.9 cm and weighed 3.9 g. Further follow-up clinical data on the hamster could not be obtained.On gross examination, both the primary and the recurrent neoplasms were bro...

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Ductal carcinoma of male breast with prominent lipid-rich component

Cited by 31 publications

References 5 publications

Lipid-rich Carcinoma of the Mammary Gland in a Cat

Lipid-rich Carcinoma of the Mammary Gland in a Cat

Original paper Sebaceous carcinoma of the breast: report of four cases and review of the literature

Lipid-Rich Carcinoma in the Mammary Gland of a Djungarian Hamster (Phodopus Sungorus)

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