Dual-time-point FDG-PET for evaluation of lymph node metastasis in patients with non-small-cell lung cancer

Nishiyama, Yoshihiro; Yamamoto, Yuka; Kimura, Naruhide; Ishikawa, Shinya; Sasakawa, Yasuhiro; Ohkawa, Motoomi

doi:10.1007/s12149-007-0103-2

Cited by 36 publications

(38 citation statements)

References 15 publications

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“…DTPI has been considered helpful for the discrimination of benign and malignant disease, and the staging of lymph node status in patients with pulmonary malignancy [6][7][8]. As regards our cases, DTPI may be also useful for showing the description of metabolic status and the extent of benign infectious disease.…”

Section: Discussionmentioning

confidence: 99%

“…If one adopts the criterion that more than a 10% increase of standardized uptake value (SUV) between the initial and delayed scan signals malignancy, significant improvement in the diagnostic accuracy for the detection of malignant pulmonary nodules has been observed [7]. DTPI has also been applied to stage lymph node status in patients with pulmonary malignancy, and DTPI showed better specificity, positive predictive value and accuracy [8].…”

Section: Introductionmentioning

confidence: 99%

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Experience of Dual Time Point Brain F-18 FDG PET/CT Imaging in Patients with Infectious Disease

Kim

Park

et al. 2010

Nucl Med Mol Imaging

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Dual time point FDG PET imaging (DTPI) has been considered helpful for discrimination of benign and malignant disease, and staging lymph node status in patients with pulmonary malignancy. However, DTPI for benign disease has been rarely reported, and it may show a better description of metabolic status and extent of benign infectious disease than early imaging only. The authors report on the use F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) imaging with additional delayed imaging on a 52-year-old man with sparganosis and a 70-year-old man with tuberculous meningitis. To the best of our knowledge, this is the first report on dual time point PET/CT imaging in patients with cerebral sparganosis and tuberculous meningitis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Experience of Dual Time Point Brain F-18 FDG PET/CT Imaging in Patients with Infectious Disease

Kim

Park

et al. 2010

Nucl Med Mol Imaging

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“…The primary tumour and lymph nodes that were .1.0 cm in short axis or PET positive were delineated as the gross target volume (GTV) or ITV. The positive lymph nodes were diagnosed in consultation with the nuclear medicine physician [12].…”

Section: Treatment Procedures Of Radiation Therapymentioning

confidence: 99%

Radiation pneumonitis in patients with lung and mediastinal tumours: a retrospective study of risk factors focused on pulmonary emphysema

Kimura¹,

Togami²,

Takashima³

et al. 2012

BJR

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Objectives: To evaluate the impact of pulmonary emphysema (PE) on the incidence and severity of radiation pneumonitis (RP) in patients with lung and mediastinal tumours. Methods: 92 patients were enrolled. Involved-field radiation therapy (non-small cell carcinoma or mediastinal tumours in 69 patients; median 70 Gy) and accelerated hyperfractionation (limited disease small cell carcinoma in 23 patients; median 45 Gy) were performed. Common Terminology Criteria for Adverse Events v.3.0 was used to evaluate RP and the relationship with the percentage of pulmonary volume irradiated to .20 Gy (V20) and PE. PE was diagnosed by the presence of low-attenuation areas (LAAs) on CT scans and was classified into Grades 0-4 according to the extent of the LAAs. Results: The median follow-up time was 16 months. The 6-month cumulative incidence of RP at Grade 3 or greater was 7.7% and 34.1% in patients with a V20 of ,25% and >25%, respectively (p50.017). In patients with PE Grades 0, 1, 2 and 3 or greater, the incidence of RP was 16.5%, 9.1%, 8.6% and 54.0%, respectively. As the PE Grade increased, the incidence of RP also increased significantly. Conclusion: The incidence and severity of RP are significantly higher in patients with a high V20 value as well as in those with severe PE.

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“…Nishiyama et al also evaluated the diagnostic performance of DTP PET/CT for the diagnosis of LN metastasis in patients with NSCLC. They reported that DTP PET showed better (although not statistically significant) specificity, positive predictive value, and accuracy than early or delayed PET alone for LN staging in NSCLC [6]. Other studies also have described the advantages of DTP PET/CT for the evaluation of mediastinal LN metastasis [7,8].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, in several studies, it has been proposed that dual-time-point (DTP) FDG PET/ CT may improve the accuracy of LN staging in NSCLC [6][7][8]. However, other studies reported that single-timepoint (STP) FDG PET/CT at 1 h after FDG injection was sufficiently useful for LN staging in NSCLC, and the usefulness of DTP PET/CT is still controversial [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Dual-time-point FDG PET/CT: Is It Useful for Lymph Node Staging in Patients with Non-Small-Cell Lung Cancer?

Kim

2012

Nucl Med Mol Imaging

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Purpose Dual-time-point (DTP) FDG PET/CT has been shown to be useful for lymph node (LN) staging in patients with non-small-cell lung cancer (NSCLC). The aim of this study was to evaluate the LN staging ability of DTP FDG PET/CT in the predominant area of pulmonary tuberculosis. Methods Sixty-nine NSCLC patients underwent DTP PET/ CT. Regions of interest were placed on each LN of each station, and the maximum SUVs were measured. Three variables were obtained: (1) the SUV on the early scan (SUV early ), (2) the SUV on the delayed scan (SUV delayed ), and (3) the retention index of the SUV (RI). Each patient had one final LN stage and three other LN stages according to the cutoff values of SUV early , SUV delayed , and RI. Results In the LN-based analysis, the area under the ROC curve of SUV delayed (0.884) was significantly larger (P< 0.01) than those of SUV early (0.868) and RI (0.717). Among the three variables, SUV delayed was more accurate (P<0.01) for detecting the mediastinal LN metastasis than SUV early and RI. In the patient-based analysis, SUV delayed had correctly determined LN stages in 55 of 69 patients (sensitivity, specificity, and accuracy088.7 %, 50.0 %, and 79.7 %), whereas SUV early and RI correctly determined LN stages in 53 and 52 patients, respectively. Conclusions In this study, comparing the diagnostic efficacy of SUV early , SUV delayed , and RI for LN staging in patients with NSCLC, SUV delayed was the most accurate variable for LN staging. DTP PET/CT could provide improved diagnostic accuracy for the LN staging of NSCLC.

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Dual-time-point FDG-PET for evaluation of lymph node metastasis in patients with non-small-cell lung cancer

Abstract: Dual-time-point FDG-PET (combined delayed PET and RI) showed better (although not statistically significant) specificity, positive predictive value, and accuracy than early or delayed PET alone for lymph node staging in NSCLC.

Cited by 36 publications

References 15 publications

Experience of Dual Time Point Brain F-18 FDG PET/CT Imaging in Patients with Infectious Disease

Experience of Dual Time Point Brain F-18 FDG PET/CT Imaging in Patients with Infectious Disease

Radiation pneumonitis in patients with lung and mediastinal tumours: a retrospective study of risk factors focused on pulmonary emphysema

Dual-time-point FDG PET/CT: Is It Useful for Lymph Node Staging in Patients with Non-Small-Cell Lung Cancer?

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