volume 269, issue 1, P185-194 2004
DOI: 10.1016/j.ijpharm.2003.09.031
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Abstract: The synthesis and characterisation of semi-interpenetrating polymeric networks obtained by the radical-induced polymerisation of N-isopropylacrylamide in the presence of chitosan using tetraethyleneglycoldiacrylate as the crosslinker is described. The influence of the degree of crosslinking and that of the ratio of chitosan to poly(N-isopropylacrylamide) on the "pH/temperature induced" phase transition behaviour and swelling characteristics of the hydrogel system are investigated. The ability of the same syste…

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