Dual regeneration of muscle and nerve by intravenous administration of human amniotic fluid–derived mesenchymal stem cells regulated by stromal cell–derived factor-1α in a sciatic nerve injury model

Yang, Dar Yu; Sheu, Meei-Ling; Su, Hong; Cheng, Fu Chou; Chen, Ying‐Ju; Chen, Chun‐Jung; Chiu, Wen Ta; Yiin, Jia Jean; Sheehan, Jason P.; Pan, Hung Chuan

doi:10.3171/2012.2.jns111360

Cited by 49 publications

(41 citation statements)

References 27 publications

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“…However, in the absence of cells, attempts to replicate the structural complexity of the nerve have led to disappointing results. Recent evidence exists that systemic administration of stem cells following peripheral nerve injury can be efficacious ( Figure 2E) [5,114] . With further refinement, it may become possible to sustain regenerative support through regular systemic dosing.…”

Section: Cell Scaffolds and Methods Of Deliverymentioning

confidence: 99%

“…Stromal cell-derived factor-1α (SDF-1α) is chemotactic towards MSCs and is expressed in several tissues in the rat, including injured nerve. By timing intravenous administration of AFDSCs with peak expression of SDF-1α, this novel approach has been shown to improve AFDSC numbers at the repair site and nerve regeneration [114] . Fetal tissue represents a promising alternative source of stem cells.…”

Section: Bone Marrow Derived Stem Cellsmentioning

confidence: 99%

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Augmenting peripheral nerve regeneration using stem cells: A review of current opinion

Fairbairn

Meppelink

Ng-Glazier

et al. 2015

WJSC

126

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Outcomes following peripheral nerve injury remain frustratingly poor. The reasons for this are multifactorial, although maintaining a growth permissive environment in the distal nerve stump following repair is arguably the most important. The optimal environment for axonal regeneration relies on the synthesis and release of many biochemical mediators that are temporally and spatially regulated with a high level of incompletely understood complexity. The Schwann cell (SC) has emerged as a key player in this process. Prolonged periods of distal nerve stump denervation, characteristic of large gaps and proximal injuries, have been associated with a reduction in SC number and ability to support regenerating axons. Cell based therapy offers a potential therapy for the improvement of outcomes following peripheral nerve reconstruction. Stem cells have the potential to increase the number of SCs and prolong their ability to support regeneration. They may also have the ability to rescue and replenish populations of chromatolytic and apoptotic neurons following axotomy. Finally, they can be used in non-physiologic ways to preserve injured tissues such as denervated muscle while neuronal ingrowth has not yet occurred. Aside from stem cell type, careful consideration must be given to differentiation status, how stem cells are supported following transplantation and how they will be delivered to the site of injury. It is the aim of this article to review current opinions on the strategies of stem cell based therapy for the augmentation of peripheral nerve regeneration.

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Section: Cell Scaffolds and Methods Of Deliverymentioning

confidence: 99%

Section: Bone Marrow Derived Stem Cellsmentioning

confidence: 99%

Augmenting peripheral nerve regeneration using stem cells: A review of current opinion

Fairbairn

Meppelink

Ng-Glazier

et al. 2015

WJSC

126

View full text Add to dashboard Cite

show abstract

“…25,29,33,34,49,55 It has been found that pre-differentiation of stem cells into the Schwann cell phenotype in vitro prior to injection results in remarkably better outcomes compared with the use of undifferentiated SKPs or mesenchymal stem cells. 16,47,48 In previous studies, we and others showed that SKPs, predifferentiated in vitro into Schwann cells (SKP-SCs), survived in vivo and promoted robust axonal regrowth both in vitro and in acute and chronic models of rodent nerve injury.…”

Section: Discussionmentioning

confidence: 99%

Sensory recovery after cell therapy in peripheral nerve repair: effects of naïve and skin precursor-derived Schwann cells

Shakhbazau

Mohanty²,

Kumar

et al. 2014

JNS

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Object Cell therapy is a promising candidate among biological or technological innovations sought to augment microsurgical techniques in peripheral nerve repair. This report describes long-term functional regenerative effects of cell therapy in the rat injury model with a focus on sensory recovery. Methods Schwann cells were derived from isogenic nerve or skin precursor cells and injected into the transected and immediately repaired sciatic nerve distal to the injury site. Sensory recovery was assessed at weeks 4, 7, and 10. Axonal regeneration was assessed at Week 11. Results By Week 10, thermal sensitivity in cell therapy groups returned to a level indistinguishable from the baseline (p > 0.05). Immunohistochemistry at 11 weeks after injury showed improved regeneration of NF+ and IB4+ axons. Conclusions: The results of this study show that cell therapy significantly improves thermal sensation and the number of regenerated sensory neurons at 11 weeks after injury. These findings contribute to the view of skin-derived stem cells as a reliable source of Schwann cells with therapeutic potential for functional recovery in damaged peripheral nerve.

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“…Chemokines with chemokine receptors CXCR3, CXCR4 and CXCR6 were identified as the key players responsible for cell homing [44]. Further, CXCR4 ligands such as stromal cell-derived factor-1a (SDF-1a) promote MSCs' migration to the injury site [45]. Apart from migration and homing, recent studies have focused on cell free approaches such as EV [46].…”

Section: Mscs and Bpdmentioning

confidence: 99%

Stem cells and Bronchopulmonary Dysplasia - The five questions: Which cells, when, in which dose, to which patients via which route?

Mueller

Kramer

2017

Paediatric Respiratory Reviews

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Dual regeneration of muscle and nerve by intravenous administration of human amniotic fluid–derived mesenchymal stem cells regulated by stromal cell–derived factor-1α in a sciatic nerve injury model

Cited by 49 publications

References 27 publications

Augmenting peripheral nerve regeneration using stem cells: A review of current opinion

Augmenting peripheral nerve regeneration using stem cells: A review of current opinion

Sensory recovery after cell therapy in peripheral nerve repair: effects of naïve and skin precursor-derived Schwann cells

Stem cells and Bronchopulmonary Dysplasia - The five questions: Which cells, when, in which dose, to which patients via which route?

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