Dual purpose Prussian blue nanoparticles for cellular imaging and drug delivery: a new generation of T1-weighted MRI contrast and small molecule delivery agents

Composite iron oxide–Prussian blue nanoparticles for magnetically guided T₁-weighted magnetic resonance imaging and photothermal therapy of tumors

“…Finally, studies conducted to calculate the photothermal conversion efficiency ( Figure 4D) demonstrated that the nanoparticles had a photothermal conversion efficiency of 16.1%, which is consistent with the previously determined photothermal conversion efficiency of Prussian blue nanoparticles (around 20%) 35 despite others). 32,38,39 Similarly, T2W scans demonstrated that the Fe 3 O 4 @GdPB nanoparticles generated increased contrast in a concentration-dependent manner ( Figure 3B), ie, increased darkening with increasing concentrations, similar to Fe 3 O 4 nanoparticles, which have been well-described in the literature. 5,6 Based on image processing of multiple T1W and T2W scans, we generated relaxation time plots as a function of the contrast agent, namely Gd 3+ ions for GdPB ( Figure 3C) and Fe 3 O 4 @GdPB ( Figure 3D), and Fe for Fe 3 O 4 ( Figure 3E) and Fe 3 O 4 @GdPB ( Figure 3F).…”

Enzyme-triggered tyramine-enzyme repeats on prussian blue-gold hybrid nanostructures for highly sensitive electrochemical immunoassay of tissue polypeptide antigen

“…Monoclonal rabbit anti-human TPA capture antibody (denoted as mAb 1 ) and polyclonal rabbit anti-human TPA detection antibody (denoted as pAb 2 ) were purchased from Baomanbio Inc. (Shanghai, China). At the first step, prussian blue nanoparticles were synthesized referring to the literature with some minor modification (Fu et al, 2012;Shokouhimehr et al, 2010). Initially, 5 mL of 1.0 mM FeCl 3 aqueous solution was mixed with 5 mL of 1.0 mM K 4 [Fe(CN) 6 ] solution containing 0.2 mmol citric acid.…”

Prussian blue/serum albumin/indocyanine green as a multifunctional nanotheranostic agent for bimodal imaging guided laser mediated combinatorial phototherapy

“…PB and its analogues possess magnetic properties, so PB nanoparticles can act as an MRI contrast agent [16]. In addition, recently PB nanoparticles have also emerged as a new generation of photothermal agent owing to its high absorption in the NIR spectrum [17,18].…”