Dual-Mode SERS-Fluorescence Immunoassay Using Graphene Quantum Dot Labeling on One-Dimensional Aligned Magnetoplasmonic Nanoparticles

Zou, Fengming; Zhou, Hongjian; Tran, Van Tan; Kim, Jeonghyo; Koh, Kwangnak; Lee, Jaebeom

doi:10.1021/acsami.5b02523

Cited by 103 publications

(65 citation statements)

References 47 publications

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“…The Raman spectrum of the GQDs (Fig. 36,37 Similar to the G 0 mode, the evolution of this M band coupled with the increasing number of graphene layers could be inicted by that of electronic band with graphene lm structure. Furthermore, the other peak at 1750 cm À1 was clearly observed in Fig.…”

Section: Resultsmentioning

confidence: 92%

Simultaneous enhancement of Raman scattering and fluorescence emission on graphene quantum dot-spiky magnetoplasmonic supra-particle composite films

et al. 2015

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Graphene quantum dots (GQDs) are a new type of quantum dot that have low cytotoxicity, excellent solubility, chemical inertia, and stable photoluminescence and Raman signal, and are promising materials for various applications. Due to their Raman scattering (RS)-fluorescence emission (FE) multi-mode optical property, GQDs have been considered as an important candidate for applications in photovoltaics, light-emitting devices, bioimaging and diagnostic techniques. However, GQD-related applications are severely restricted because of the high signal attenuation, low contrast, and low resolution. To overcome these problems, we have designed a reliable strategy for enhancing the RS-FE of GQDs to make them suitably efficient for their applications. In this study, we utilized spiky Au-coated Fe 3 O 4 supraparticles (Fe 3 O 4 @Au SPs) to enhance the RS-FE of the GQDs by fabricating layer-by-layer (LbL) assembled GQD-spiky Fe 3 O 4 @Au SPs composite films. The RS and FE enhancements of 13-fold and 7.8-fold, respectively, were observed for the GQD-spiky Fe 3 O 4 @Au SPs composite films. It is also proved that external magnetic fields have an attenuation effect on the Raman activity of spiky Fe 3 O 4 @Au SPs. Moreover, the GQD-spiky Fe 3 O 4 @Au SPs composite films exhibited remarkable multi-mode imaging capabilities for Raman mapping and fluorescence imaging, which are expected to find application in photonic devices.

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Section: Resultsmentioning

confidence: 92%

Simultaneous enhancement of Raman scattering and fluorescence emission on graphene quantum dot-spiky magnetoplasmonic supra-particle composite films

et al. 2015

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“…[78] To detect viruses, DNA, RNA, and biomolecules, PRET-based FIs have been developed by using several plasmonic nanomaterials, including MeNPs, core/shell NPs, MeNP-CNMs, inorganic QDs, carbon dots, and GRP-QDs. [79][80][81][82][83] Takemura et al reported the detection of influenza virus through the PRET effect by using urchin-like Au NPs (u-Au NPs) and inorganic CdSeTeS QDs (Figure 3). [84] In this system, the u-Au NPs were utilized as a plasmonic substrate for energy transfer, while the QDs acted as the fluorescence indicator and captured the target influenza virus.…”

Section: Fluorescent Qds For Biosensing Systemsmentioning

confidence: 99%

High‐Performance Biosensing Systems Based on Various Nanomaterials as Signal Transducers

Lee

Adegoke

Park

2018

Biotechnology Journal

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Recently, highly sensitive and selective biosensors have become necessary for improving public health and well-being. To fulfill this need, high-performance biosensing systems based on various nanomaterials, such as nanoparticles, carbon nanomaterials, and hybrid nanomaterials, are developed. Numerous nanomaterials show excellent physical properties, including plasmonic, magnetic, catalytic, mechanical and fluorescence properties and high electrical conductivities, and these unique and beneficial properties have contributed to the fabrication of high-performance biosensors with various applications, including in optical, electrical, and electrochemical detection platforms. In addition, these properties can be transformed to signals for the detection of biomolecules. In this review, various types of nanomaterial-based biosensors are introduced, and they show high sensitivity and selectivity. In addition, the potential applications of these sensors on the biosensing of several types of biomolecules are also discussed. These nanomaterials-based biosensing systems provide a significant improvement on healthcare including rapid monitoring and early detection of infectious disease for public health.

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“…A dual-mode surface enhanced Raman scattering and fluorescence immunoassay using graphene QDs labels on one-dimensional aligned magneto-plasmonic nanoparticles has been recently developed by Zou et al [98] and used for the diagnostic detection of tuberculosis antigen CFP-10, reaching the excellent analyte detection limit of 0.0511 pg/mL. Dong et al developed multifunctional poly(L-lactide)-polyethylene glycol-grafted photoluminescent graphene quantum dots for intracellular microRNA imaging in HeLa cells [99].…”

Section: Quantum Dots For Diagnostics and Therapymentioning

confidence: 99%

Quantum dots in nanomedicine: recent trends, advances and unresolved issues

Volkov

2015

Biochemical and Biophysical Research Communications

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a b s t r a c tThe review addresses the current state of progress in the use of ultra-small nanoparticles from the category of quantum dots (QDs), which presently embraces a widening range of nanomaterials of different nature, including "classical" semiconductor groups III-V and II-VI nanocrystals, along with more recently emerged carbon, silicon, gold and other types of nanoparticles falling into this class of nanomaterials due to their similar physical characteristics such as small size and associated quantum confinement effects. A diverse range of QDs applications in nanomedicine has been extensively summarised previously in numerous publications. Therefore, this review is not intended to provide an all-embracing survey of the well documented QDs uses, but is rather focused on the most recent emerging developments, concepts and outstanding unresolved problematic and sometimes controversial issues. Over 125 publications are overviewed and discussed here in the context of major nanomedicine domains, i.e. medical imaging, diagnostics, therapeutic applications and combination of them in multifunctional theranostic systems.© 2015 Elsevier Inc. All rights reserved. Quantum dots in nanomedicine: recent trendsWithin a steadily increasing database of diverse nanomaterials reported as suitable for applications in nanomedicine [1e10], quantum dots (QDs) deservedly occupy a special niche as nanoparticles with a unique track record full of high expectations, dramatic pitfalls and often controversial experimental evidence. From the early optimistic aspirations of them as breakthrough tools for multipurpose in vitro and in vivo applications [11e17], they have been subject to a period of partial relinquishment following the sombre realisation that in the original unmodified state QDs did not stand a chance to deserve a unanimous approval as imaging or drug delivery vehicles in humans, due to their intrinsic toxicity and lack of biodegradability perspective. The disappointingly low yield of exploitable outputs following the initial rounds of heavy investments in the field has also contributed to the overall decline in research productivity metrics. The analysis of the recent ten years' trends in publications number in this area related to the QDs medical applications in vivo in general (Fig. 1 A), as well as for imaging and diagnostics purposes (Fig. 1 B, C) according to Thomson Reuters Web of Science™ database clearly reflects such "cooling down" period after 2010 resulting in a significant reduction in the initially steady exponential growth of publication rates. This trend has been partially or completely reversed by 2014 and it is intriguing whether we will see it sustained in 2015 and beyond.Such returning enthusiasm has been reinvigorated by a number of objective tendencies in the related technological developments, including the arrival of innovative nanotechnology-enabled tools for diagnostic and ex vivo imaging applications [18,19], the arrival of new types of QDs of alternative nature offering the opportunities of r...

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Dual-Mode SERS-Fluorescence Immunoassay Using Graphene Quantum Dot Labeling on One-Dimensional Aligned Magnetoplasmonic Nanoparticles

Cited by 103 publications

References 47 publications

Simultaneous enhancement of Raman scattering and fluorescence emission on graphene quantum dot-spiky magnetoplasmonic supra-particle composite films

Simultaneous enhancement of Raman scattering and fluorescence emission on graphene quantum dot-spiky magnetoplasmonic supra-particle composite films

High‐Performance Biosensing Systems Based on Various Nanomaterials as Signal Transducers

Quantum dots in nanomedicine: recent trends, advances and unresolved issues

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