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Cited by 135 publications
(98 citation statements)
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“…In the present study, we designed a Mg-incorporated scaffold with PLGA as the matrix using a low-temperature rapid-prototyping technique to repair small criticalsized bone defects with antibacterial activity. It has been reported that the addition of Mg particles to the PLGA scaffolds would increase the compressive strength and modulus compared with PLGA-only scaffolds [18,19]. In our study, the compression moduli of the PM-H and PM-L scaffolds increased by 134.2% and 86.3%, respectively, compared to the PLGA-only scaffolds (Fig.…”
Section: Discussionsupporting
confidence: 53%
“…In the present study, we designed a Mg-incorporated scaffold with PLGA as the matrix using a low-temperature rapid-prototyping technique to repair small criticalsized bone defects with antibacterial activity. It has been reported that the addition of Mg particles to the PLGA scaffolds would increase the compressive strength and modulus compared with PLGA-only scaffolds [18,19]. In our study, the compression moduli of the PM-H and PM-L scaffolds increased by 134.2% and 86.3%, respectively, compared to the PLGA-only scaffolds (Fig.…”
Section: Discussionsupporting
confidence: 53%
“…The addition of HA induced an improvement of mechanical properties as demonstrated by the CS = 30 MPa and E = 1.9 GPa, which appeared to be intermediate between mechanical properties of the cancellous and cortical bones . These results demonstrated that this approach allowed to design and manufacture 3D‐printed scaffolds as bone substitutes with mechanical properties reassembling closely those of bone tissues, which could be applied in vivo for cortical and cancellous bone repair . The authors also proved that the use of quaternized chitosan decreased bacterial adhesion and biofilm formation under in vitro and in vivo conditions, disrupting microbial membranes and inhibiting the biofilm formation.…”
Section: Hard Matrix‐based Compositesmentioning
confidence: 79%
“…Female New Zealand white rabbits (3.0 ± 0.8 kg, Animal Center of Chongqing Medical University) were used to establish an infected femoral metaphysis model . Cylinder‐shaped bony defect (2.8 mm × 8 mm) perpendicular to the femoral metaphysis was created under sterile conditions according to the previous method . Eighteen rabbits were assigned to three groups randomly, namely, control Ti implants ( n = 6), AH‐Sr‐AgNPs implants ( n = 6), and AH‐Sr‐AgNPs implants locally injected with AP20187 ( n = 6, abbreviated as AH‐Sr‐AgNPs+AP20187).…”
Section: Methodsmentioning
confidence: 99%