Dual drug-loaded hydrogels with pH-responsive and antibacterial activity for skin wound dressing

Du, Miao; Jin, Jing; Zhu, Feng; Chen, Jiayue; Jiang, Wei

doi:10.1016/j.colsurfb.2022.113063

Cited by 25 publications

(14 citation statements)

References 45 publications

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“…It is worth noting that the levels of the antibacterial efficiency reached through the newly developed hydrogels are extremely high. Similar but not matched antibacterial performance have been reached in very few studies, − see Figure .…”

Section: Results and Discussionmentioning

confidence: 52%

Biomimetic Antibacterial Gelatin Hydrogels with Multifunctional Properties for Biomedical Applications

Ruan,

Bek,

Pandit

et al. 2023

ACS Appl. Mater. Interfaces

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A facile novel approach of introducing dopamine and [2-(methacryloyloxy) ethyl] dimethyl-(3-sulfopropyl) ammonium hydroxide via dopamine-triggered in situ synthesis into gelatin hydrogels in the presence of ZnSO4 is presented in this study. Remarkably, the resulting hydrogels showed 99.99 and 100% antibacterial efficiency against Gram-positive and Gram-negative bacteria, respectively, making them the highest performing surfaces in their class. Furthermore, the hydrogels showed adhesive properties, self-healing ability, antifreeze properties, electrical conductivity, fatigue resistance, and mechanical stability from −100 to 80 °C. The added multifunctional performance overcomes several disadvantages of gelatin-based hydrogels such as poor mechanical properties and limited thermostability. Overall, the newly developed hydrogels show significant potential for numerous biomedical applications, such as wearable monitoring sensors and antibacterial coatings.

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Section: Results and Discussionmentioning

confidence: 52%

Biomimetic Antibacterial Gelatin Hydrogels with Multifunctional Properties for Biomedical Applications

Ruan,

Bek,

Pandit

et al. 2023

ACS Appl. Mater. Interfaces

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“…2e) shows the CN bond at 410.9 eV and C–N bond at 399.4 eV. 26,27 The formation of Schiff base proves the successful crosslinking of the hydrogel.…”

Section: Resultsmentioning

confidence: 92%

Preparation and properties of biocompatible and injectable hydrogels for bladder cancer drug delivery

Deng¹,

Li²,

li³

et al. 2023

New J. Chem.

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“…CG was found to have a strong affinity for platelets, which aided in rapid hemostasis, enabling the dressing to halt bleeding within 10 seconds. Du and colleagues [43] developed a new hydrogel through photocrosslinking using gelatin methacrylate (GelMA) and hyaluronic acid aldehyde (HA-CHO). The hydrogel was loaded with either gentamicin sulfate (GS) or a combination of GS and lysozyme (LZM).…”

Section: Drug Hemostasis For Hydrogel Dressingsmentioning

confidence: 99%

Functional hydrogel dressings for wound management: a comprehensive review

Fu,

Zheng,

Wen

et al. 2023

Mater. Res. Express

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Hydrogels have gained significant attention as wound dressings due to their potential for rapid healing. Researchers have actively explored a range of techniques for antimicrobial applications, including incorporating drug payloads, utilizing inorganic nanometals, and harnessing the properties of natural cationic polymers. In terms of hemostasis and coagulation promotion, techniques such as drug delivery, adhesive physical hemostasis, and adhesive functional groups have been studied. To control inflammation, researchers have investigated the application of natural antioxidants and antioxidant functional groups, which have demonstrated anti-inflammatory effects. Furthermore, the smart responsiveness of hydrogel wound dressings to pH, temperature, and light has been explored. This review presents a summary of the research progress and application prospects in these areas and offers an outlook on the future development direction of hydrogel wound dressings.

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Dual drug-loaded hydrogels with pH-responsive and antibacterial activity for skin wound dressing

Cited by 25 publications

References 45 publications

Biomimetic Antibacterial Gelatin Hydrogels with Multifunctional Properties for Biomedical Applications

Biomimetic Antibacterial Gelatin Hydrogels with Multifunctional Properties for Biomedical Applications

Preparation and properties of biocompatible and injectable hydrogels for bladder cancer drug delivery

Functional hydrogel dressings for wound management: a comprehensive review

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