Dual and multi-stimuli responsive polymeric nanoparticles for programmed site-specific drug delivery

Cheng, Ru; Meng, Fenghua; Deng, Chao; Klok, Harm‐Anton; Zhong, Zhiyuan

doi:10.1016/j.biomaterials.2013.01.084

Cited by 1,160 publications

(692 citation statements)

References 83 publications

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“…One appealing strategy that has emerged recently is the introduction of polymeric nanoparticle systems that can respond to multiple stimuli associated with pathological conditions29 and thereby assuring cargo release in biomedical applications. However, there is only a limited number of literature reports available so far describing polymeric hollow capsules28, 30, 31 and polymersomes32 that can modulate drug release in response to the combinations of dual stimuli such as pH/temperature,26, 33 pH/reduction,30 temperature/reduction,32 and enzyme/enzyme 28, 34.…”

Section: Introductionmentioning

confidence: 99%

Photo‐Cross‐Linked Dual‐Responsive Hollow Capsules Mimicking Cell Membrane for Controllable Cargo Post‐Encapsulation and Release

et al. 2016

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Multifunctional and responsive hollow capsules are ideal candidates to establish highly sophisticated compartments mimicking cell membranes for controllable bio‐inspired functions. For this purpose pH and temperature dual‐responsive and photo‐cross‐linked hollow capsules, based on silica‐templated layer‐by‐layer approach by using poly(N‐isopropyl acrylamide)‐block‐polymethacrylate) and polyallylamine, have been prepared to use them for the subsequent and easily available post‐encapsulation process of protein‐like macromolecules at room temperature and pH 7.4 and their controllable release triggered by stimuli. The uptake and release properties of the hollow capsules for cargos are highly affected by changes in the external stimuli temperature (25, 37, or 45 °C) and internal stimuli pH of the phosphate‐containing buffer solution (5.5 or 7.4), by the degree of photo‐cross‐linking, and the size of cargo. The photo‐cross‐linked and dual stimuli‐responsive hollow capsules with different membrane permeability can be considered as attractive material for mimicking cell functions triggered by controllable uptake and release of different up to 11 nm sized biomolecules.

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Section: Introductionmentioning

confidence: 99%

Photo‐Cross‐Linked Dual‐Responsive Hollow Capsules Mimicking Cell Membrane for Controllable Cargo Post‐Encapsulation and Release

et al. 2016

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“…Specifically, by recognizing their microenvironment, they enable on-demand processes (also termed as "switch on/off") and react in a dynamic way, which in turn mimic the responsiveness of living organisms. [622] It was in the late 1970s that Yatvin et al suggested the concepts of stimuli responsive drug delivery by employing thermosensitive polymers and hyperthermia for the local release of drugs. [623] Broadly speaking, temperature changes, light, ultrasound, electric fields, and magnetic fields are of exogenous stimuli exploited for triggering drug release.…”

Section: Magnetic Drug Targetingmentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

181

162

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In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non‐invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section. This study provides a conceptual framework of a wide range of synthetic routes classified mainly as wet chemistry, state‐of‐the‐art microfluidic reactors, and biogenic routes, along with the most popular coating materials to stabilize resultant MNPs. Additionally, key aspects of prolonging the half‐life of MNPs via overcoming the sequential biological barriers are covered through unraveling the biophysical interactions at the bio–nano interface and giving a set of criteria to efficiently modulate MNPs' physicochemical properties. Furthermore, concepts of passive and active targeting for successful cell internalization, by respectively exploiting the unique properties of cancers and novel targeting ligands are described in detail. Finally, this study extensively covers the recent developments in magnetic drug targeting and hyperthermia as therapeutic applications of MNPs. In addition, multi‐modal imaging via fusion of magnetic resonance imaging, and also innovative magnetic particle imaging with other imaging techniques for early diagnosis of diseases are extensively provided.

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“…3,5,6 To achieve a faster drug release at the tumor site or inside tumor cells, more and more polymeric micellar drug carriers were designed to respond to the intrinsic environment of tumor. [7][8][9] In particular, redox-responsive drug carriers are attractive due to the high reducing potential at the tumor site and inside tumor cells. 9 Generally, redoxresponsive drug carriers are prepared from reducible polymers.…”

Section: Introductionmentioning

confidence: 99%

Effects of copolymer component on the properties of phosphorylcholine micelles

Wu¹,

Cai²,

Cao³

et al. 2017

IJN

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Dual and multi-stimuli responsive polymeric nanoparticles for programmed site-specific drug delivery

Cited by 1,160 publications

References 83 publications

Photo‐Cross‐Linked Dual‐Responsive Hollow Capsules Mimicking Cell Membrane for Controllable Cargo Post‐Encapsulation and Release

Photo‐Cross‐Linked Dual‐Responsive Hollow Capsules Mimicking Cell Membrane for Controllable Cargo Post‐Encapsulation and Release

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Effects of copolymer component on the properties of phosphorylcholine micelles

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