Dry Eye in the Beaver Dam Offspring Study: Prevalence, Risk Factors, and Health-Related Quality of Life

Abstract

Purpose To estimate dry eye prevalence in the Beaver Dam Offspring Study (BOSS), including a young adult population, and investigate associated risk factors and impact on health-related quality of life. Design Cohort study. Methods The BOSS (2005–2008) is a study of aging in the adult offspring of the population-based Epidemiology of Hearing Loss Study cohort. Questionnaire data on health history, medication use, risk factors, and quality of life were available for 3275 participants. Dry eye was determined by self-report of frequency of symptoms and the intensity of those symptoms. Associations between dry eye and risk factors were analyzed using logistic regression. Results The prevalence of dry eye in the BOSS was 14.5%, 17.9% of women and 10.5% of men. In a multivariate model, statistically significant associations were found with female sex (Odds Ratio (OR), 1.68; 95% Confidence Interval (CI), 1.33–2.11), current contact lens use (OR, 2.01; 95%CI, 1.53–2.64), allergies (OR, 1.59; 95%CI 1.22–2.08), arthritis (OR, 1.44; 95%CI, 1.12–1.85), thyroid disease (OR, 1.43; 95%CI, 1.02–1.99), antihistamine use (OR, 1.54; 95%CI, 1.18–2.02), and steroid use (OR, 1.54; 95%CI, 1.16–2.06). Dry eye was also associated with lower scores on the Medical Outcomes Short Form-36 (β=−3.9, p<0.0001) as well as on the National Eye Institute Visual Functioning Questionnaire (NEI-VFQ-25) (β= −3.4, p<0.0001) when controlling for age, sex, and comorbid conditions. Conclusions The prevalence of dry eye and its associated risk factors in the BOSS were similar to previous studies. In this study, DES was associated with lower quality of life on a health-related quality of life instrument and the vision-specific NEI-VFQ-25.

The role of dinucleoside polyphosphates on the ocular surface and other eye structures

“…The other main factor to develop dry eye is gender, it being more common in women than men. The Beaver Dam study showed a prevalence of dry eye of 18% in women and only 11% in men, and some other studies described even higher differences between women and men (Paulsen et al, 2014). The principal reason for these differences would be the hormonal factor (Guillon and Maissa, 2010).…”

Methods for detection of dry eye in critically ill patients: An Integrative Review

“…Based on OSDI score, the ocular surface is defined as normal (0-12), mild (13)(14)(15)(16)(17)(18)(19)(20)(21)(22), moderate (23)(24)(25)(26)(27)(28)(29)(30)(31)(32), or severe (33-100) [44]. It is noteworthy that although the OSDI is not routinely used in clinical practice, it has been shown to be valid and reliable to quantify the impact of dry eye on the quality of life [44].…”

Prevalencia de síntomas de enfermedad de la superficie ocular en pacientes que acuden a consulta oftalmológica

“…Es una enfermedad multifactorial de la superficie ocular que afecta a la película lagrimal provocando su inestabilidad, dando como resultado síntomas de malestar ocular, alteraciones visuales y un potencial daño de las estructuras oculares externas 2 . La prevalencia de la enfermedad ha sido ampliamente estudiada con resultados muy variables, desde el 5% hasta más del 70% en personas mayores de 50 años 1,[3][4][5][6][7][8][9][10][11][12][13] ; los resultados varían de acuerdo con la definición utilizada, los métodos diagnósticos y la población estudiada 1 . El cuestionario del Índice de Enfermedad de la Superficie Ocular (OSDI, por sus siglas en inglés) es un método muy utilizado en estudios epidemiológicos de ojo seco y enfermedad de la superficie ocular, ya que evalúa por medio de 12 preguntas no solo la sintomatología asociada a esta enfermedad, sino también el impacto en la calidad de vida de los encuestados.…”