Drugs for preventing tuberculosis in people at risk of multiple-drug-resistant pulmonary tuberculosis

Assessing the effect of foreign travel and protection by BCG vaccination on the spread of tuberculosis in a low incidence country, United Kingdom, October 2008 to December 2009

“…An approach to reduce the incidence of travelacquired TB is to use serial TST before and after travel and treat those converting to a positive test for latent infection [25]. Unfortunately the acquisition of resistant strains would make this approach less effective, with limited options for the treatment of latent infection due to multi-and extensively drug-resistant TB [30]. Furthermore, some individuals will convert from a negative to a positive TST due to previous exposure to non-tuberculous mycobacteria.…”

Assessing the effect of foreign travel and protection by BCG vaccination on the spread of tuberculosis in a low incidence country, United Kingdom, October 2008 to December 2009

“…An approach to reduce the incidence of travelacquired TB is to use serial TST before and after travel and treat those converting to a positive test for latent infection [25]. Unfortunately the acquisition of resistant strains would make this approach less effective, with limited options for the treatment of latent infection due to multi-and extensively drug-resistant TB [30]. Furthermore, some individuals will convert from a negative to a positive TST due to previous exposure to non-tuberculous mycobacteria.…”

Failure of Chemoprophylaxis With Standard Antituberculosis Agents in Child Contacts of Multidrug-Resistant Tuberculosis Cases

“…A recent Cochrane review found no randomized control studies assessing the efficacy of treating latent tuberculosis infection in people exposed to MDR-TB. 21 Two observational studies have measured the effectiveness of treating MDR-TB contacts. A prospective cohort study of childhood contacts of MDR-TB cases in the Western Cape included 105 contacts without active disease at study entry who were followed up for 30 months.…”

Treating household contacts of MDR-TB patients: Are we being too hasty?

“…A study from South Africa by Verver and colleagues,[ 5 ] using such genotypic techniques, showed that there was only 20% concordance between households, with the rest of the infections being acquired in the community due to “extensive social mixing.” Treating such contacts infected by a sensitive strain, as if they had MDR-TB, would clearly be inappropriate. Treatment is of questionable benefit: A Cochrane review[ 6 ] of all the studies and available regimens showed that the balance of benefit versus harm in household contacts was far from clear. These authors concluded that drugs should only be offered in the context of well-designed randomized control trials (RCTs).…”

“…A Cochrane review[ 6 ] of all the studies and available regimens showed that the balance of benefit versus harm in household contacts was far from clear. These authors concluded that drugs should only be offered in the context of well-designed randomized control trials (RCTs).…”

Assessing the effect of foreign travel and protection by BCG vaccination on the spread of tuberculosis in a low incidence country, United Kingdom, October 2008 to December 2009

“…An approach to reduce the incidence of travelacquired TB is to use serial TST before and after travel and treat those converting to a positive test for latent infection [25]. Unfortunately the acquisition of resistant strains would make this approach less effective, with limited options for the treatment of latent infection due to multi-and extensively drug-resistant TB [30]. Furthermore, some individuals will convert from a negative to a positive TST due to previous exposure to non-tuberculous mycobacteria.…”

Failure of Chemoprophylaxis With Standard Antituberculosis Agents in Child Contacts of Multidrug-Resistant Tuberculosis Cases

“…A recent Cochrane review found no randomized control studies assessing the efficacy of treating latent tuberculosis infection in people exposed to MDR-TB. 21 Two observational studies have measured the effectiveness of treating MDR-TB contacts. A prospective cohort study of childhood contacts of MDR-TB cases in the Western Cape included 105 contacts without active disease at study entry who were followed up for 30 months.…”

Treating household contacts of MDR-TB patients: Are we being too hasty?

“…A study from South Africa by Verver and colleagues,[ 5 ] using such genotypic techniques, showed that there was only 20% concordance between households, with the rest of the infections being acquired in the community due to “extensive social mixing.” Treating such contacts infected by a sensitive strain, as if they had MDR-TB, would clearly be inappropriate. Treatment is of questionable benefit: A Cochrane review[ 6 ] of all the studies and available regimens showed that the balance of benefit versus harm in household contacts was far from clear. These authors concluded that drugs should only be offered in the context of well-designed randomized control trials (RCTs).…”

“…A Cochrane review[ 6 ] of all the studies and available regimens showed that the balance of benefit versus harm in household contacts was far from clear. These authors concluded that drugs should only be offered in the context of well-designed randomized control trials (RCTs).…”

Assessing the effect of foreign travel and protection by BCG vaccination on the spread of tuberculosis in a low incidence country, United Kingdom, October 2008 to December 2009

“…An approach to reduce the incidence of travelacquired TB is to use serial TST before and after travel and treat those converting to a positive test for latent infection [25]. Unfortunately the acquisition of resistant strains would make this approach less effective, with limited options for the treatment of latent infection due to multi-and extensively drug-resistant TB [30]. Furthermore, some individuals will convert from a negative to a positive TST due to previous exposure to non-tuberculous mycobacteria.…”

Failure of Chemoprophylaxis With Standard Antituberculosis Agents in Child Contacts of Multidrug-Resistant Tuberculosis Cases

“…A recent Cochrane review found no randomized control studies assessing the efficacy of treating latent tuberculosis infection in people exposed to MDR-TB. 21 Two observational studies have measured the effectiveness of treating MDR-TB contacts. A prospective cohort study of childhood contacts of MDR-TB cases in the Western Cape included 105 contacts without active disease at study entry who were followed up for 30 months.…”

Treating household contacts of MDR-TB patients: Are we being too hasty?

“…A study from South Africa by Verver and colleagues,[ 5 ] using such genotypic techniques, showed that there was only 20% concordance between households, with the rest of the infections being acquired in the community due to “extensive social mixing.” Treating such contacts infected by a sensitive strain, as if they had MDR-TB, would clearly be inappropriate. Treatment is of questionable benefit: A Cochrane review[ 6 ] of all the studies and available regimens showed that the balance of benefit versus harm in household contacts was far from clear. These authors concluded that drugs should only be offered in the context of well-designed randomized control trials (RCTs).…”

“…A Cochrane review[ 6 ] of all the studies and available regimens showed that the balance of benefit versus harm in household contacts was far from clear. These authors concluded that drugs should only be offered in the context of well-designed randomized control trials (RCTs).…”