Drug targeting using low density lipoprotein (LDL): physicochemical factors affecting drug loading into LDL particles

Kader, Abdul; Davis, Philip J.; Kara, M.; Liu, Hu

doi:10.1016/s0168-3659(98)00052-2

Cited by 46 publications

(30 citation statements)

References 37 publications

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“…Thirdly, the drug incorporation method and variables such as, incubation time, temperature, stirring, solvent, presence of surfactants, MW of PLGA, L:G ratio of PLGA, PLGA concentration, removal rate of organic solvent, etc., are also factors which may influence drug entrapment efficiency (Kader et al 1998) and this in accordance with the explanation of Zeng and Sun (2009). Figure 5a showed initial burst release profile of 54 % of 5-ALA from PLGA NPs after 24 h followed by a slower release rate that lasts for 12 days; this biphasic pattern is characterized by initial burst release followed by a slow and continuous release rate as shown in the figure.…”

Section: Characterization Of Drug Loadingsupporting

confidence: 81%

Enhanced photodynamic efficacy of PLGA-encapsulated 5-ALA nanoparticles in mice bearing Ehrlich ascites carcinoma

et al. 2013

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Nanoparticles (NPs) fabricated from the biodegradable copolymer poly(lactic-co-glycolic acid) (PLGA) were investigated as a drug delivery system to enhance the photodynamic efficacy of 5-aminolevulinic acid (5-ALA) in mice bearing Ehrlich ascites carcinoma. The PLGA-encapsulated 5-ALA NPs were prepared using binary organic solvent diffusion method and characterized in terms of shape and particle size. The in vivo photodynamic efficiency in Ehrlich ascites-bearing mice was studied. The obtained particles were uniform in size with spherical shape of mean size of 249.5 nm as obtained by particle size analyzer and the in vitro release studies demonstrated a controlled release profile of 5-ALA. Tumor-bearing mice injected with PLGA-encapsulated 5-ALA NPs exhibited significantly smaller mean tumor volume, increased tumor growth delay compared with the control group and the group injected with free 5-ALA during the time course of the experiment. Histopathological examination of tumor from mice treated with PLGAencapsulated 5-ALA NPs showed regression of tumor cells, in contrast to those obtained from mice treated with free 5-ALA. The results indicate that PLGA-encapsulated 5-ALA NPs are a successful delivery system for improving photodynamic activity in the target tissue.

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Section: Characterization Of Drug Loadingsupporting

confidence: 81%

Enhanced photodynamic efficacy of PLGA-encapsulated 5-ALA nanoparticles in mice bearing Ehrlich ascites carcinoma

et al. 2013

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“…Drinking instant coffee powder results in amelioration of abnormal lipoprotein profiles that occurred in hepatoma-bearing rats, and instant coffee powder has the ability to suppress tumor cell invasion by reducing oxidative stresses in vitro, leading to the inhibition of tumor growth and metastases (Miura et al, 2004). According to the metabolic characteristic of lipoids and lipoprotein (Chu et al, 2001;Kader et al, 1998), high-density lipoprotein has been used as a potential carrier for delivery of a lipophilic antitumoral drug into hepatoma cells (Lou et al, 2005).…”

Section: Resultsmentioning

confidence: 99%

Lipids changes in liver cancer

Jiang

Zhang

et al. 2007

J. Zhejiang Univ. - Sci. B

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Abstract:Liver is one of the most important organs in energy metabolism. Most plasma apolipoproteins and endogenous lipids and lipoproteins are synthesized in the liver. It depends on the integrity of liver cellular function, which ensures homeostasis of lipid and lipoprotein metabolism. When liver cancer occurs, these processes are impaired and the plasma lipid and lipoprotein patterns may be changed. Liver cancer is the fifth common malignant tumor worldwide, and is closely related to the infections of hepatitis B virus (HBV) and hepatitis C virus (HCV). HBV and HCV infections are quite common in China and other Southeast Asian countries. In addition, liver cancer is often followed by a procession of chronic hepatitis or cirrhosis, so that hepatic function is damaged obviously on these bases, which may significantly influence lipid and lipoprotein metabolism in vivo. In this review we summarize the clinical significance of lipid and lipoprotein metabolism under liver cancer.

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“…Other interesting approaches were immobilization of bacteriophages active against a variety of food-borne bacteria by physisorption to modified, cationic silica particles (Cademartiri et al, 2010) or use of low-density lipoproteins (LDLs) from human plasma for delivering drugs inside the cells and treat intracellular infections (Hu et al, 2000). Biopolymer particles from lipoproteins can readily be obtained from human plasma by density gradient ultracentrifugation (Kader et al, 1998). A lipid core is surrounded by a monolayer of phospholipids, in which cholesterol and apolipoprotein-B are present.…”

Section: Polymeric Lipid-based and Hybrid Particlesmentioning

confidence: 99%