Drug survival analysis of dupilumab and associated predictors in patients with atopic dermatitis in South Korea: single-center, retrospective study

Abstract

Long-term data on dupilumab drug survival in Asia patients with atopic dermatitis (AD) are limited. A single-center, retrospective study was performed to assess drug survival between March 2019 and March 2023. Drug survival and associated characteristics were analyzed using Kaplan–Meier survival curves and multivariate Cox regression analysis, respectively. A total of 124 patients with AD (Mean age [standard deviation], 26.0 [8.6] years) with a 4 years-overall dupilumab drug survival rate of 87.9%, were included in this study. During the same period, drug survival in the 479 cyclosporine patients was 0.2%, statistically different from the dupilumab group (p -value < 0.001). Characteristics associated with shorter drug survival were the low eczema area and severity index (EASI) scores at baseline (hazard ratio [HR], 0.84; 95% confidence interval [CI], 0.75–0.94, p-value = 0.003) and non-insurance coverage of dupilumab (HR, 11.87; 95% CI, 3.28–42.99, p-value = 0.001). This retrospective study demonstrated good overall 4-year dupilumab survival (87.9%) in South Korea. Patients with low baseline EASI scores and those who did not have insurance for dupilumab treatment discontinued the therapy frequently. To the best of our knowledge, this is the first long-term dupilumab drug survival study conducted in Asia with predictors.

S‐Substituted Oxadiazoles: A Multi‐Faceted Approach to Synthesis, Enzyme Inhibition, and Antibacterial Properties

“…In silico prediction of drug-likeness and ADMET of ciprofloxacin and the most potent compounds 6 e, 6 j, 6 o, and 6 a were performed using the preADMET online server. [45] Credit author statement…”