Drug specific, tuning of an ionic liquid's hydrophilic–lipophilic balance to improve water solubility of poorly soluble active pharmaceutical ingredients

How imidazolium‐based ionic liquids solubilize the poorly soluble ibuprofen? A theoretical study

“…Experimentally, plenty of efforts have been attempted to understand the relationship between ILs structure and the solvation mechanism of drugs in ILs for developing new ILs . It has been speculated from various experimental observations that hydrogen bond (HB) interactions between anions and drugs is the major reason for the favorable solvation of drugs in imidazolium‐based ILs . For example, Rogers et al indicated that the amphotericin B formed stronger HB interaction with acetate anion resulting in a higher solubility in ILs than that of itraconazole.…”

Investigation of pharmaceutically active ionic liquids as electrolyte for the electrosynthesis of polypyrrole and active component in controlled drug delivery

“…[22,24] Since 2007, Room Temperature Ionic Liquids (RTILs) containing active pharmaceutical ingredients have aroused strong interests as they limit drugs polymorphism and improve their solubility. [29][30][31][32][33] API-ILs have also been used as solvent for poorly soluble drugs [34][35][36][37][38] and as drug delivery systems in the form of microemulsions [39] and micelles. [40] Drug delivery systems have also been obtained by immobilization of API-ILs into silica either by sol-gel processing, [41] adsorption to silica [42] or into biocompatible poly(L-lactic acid).…”

‘Pro et contra’ ionic liquid drugs – Challenges and opportunities for pharmaceutical translation

“…Tuning biopharmaceutics 36 and toxicology by proper IL design is another focus. The review connects the interrelated chemical, phys- 37 ical, pharmaceutical, and toxicological outcome of IL-API, serving as guidance for the formulation scien- 38 tist who aims at expanding ones armamentarium for poorly water soluble APIs while avoiding structural 39 modification, thereof. 40 Ó 2015 Published by Elsevier B.V. 41 42 43 44 1.…”

“…acids[59,60,133] or fatty acids[38]. Novel counterions require tox-848 icological profiling, likely alone and as salts with the respective API 849 at question.…”

“…These range 77 from a use for synthesis of APIs [1,8,32], or analytical approaches 78 [33,34]. Besides these ILs were used as solvents for proteins 79 [35,36] or poorly water soluble APIs [30, [37][38][39] or as excipients 80 for the preparation of microemulsions [40][41][42]. 81 The focus of this review is on API-ILs and their potential appli- API-ILs [6,8,31,43], however, with a particular focus on pharma- 89 ceutical 'pro et contra' of these formulations and challenges and 90 opportunities of translating them into pharmaceutical and ulti- 91 mately clinical application.…”