Drug-Receptor Interactions in Methemoglobins and in Hemin Models

Exploring the Role of Imidazoles in Amine-Impregnated Mesoporous Silica for CO2 Capture

“…In addition, the possibility of deprotonation from NH of Ims should be considered. The p K a values for the deprotonation of Im is still high (14.4) compared with the p K a value for the protonation of TEPA. Thus, the deprotonation of Im in the presence of TEPA can be ignored as is the case with 4MIm.…”

“…27−29 However, compared with the pK a value of 9.64 22 for TEPA, that for the deprotonation of 4MIm is substantially high (>14.4). 30 Thus, 4MIm hardly reacts with CO 2 to form carbamate even in the presence of TEPA.…”

“…Here, we consider the possibility of 4MIm-carbamate formation followed by the deprotonation from NH of 4MIm with the protonation of TEPA, because the anionic form of Ims is more reactive to CO 2 . − However, compared with the p K a value of 9.64 for TEPA, that for the deprotonation of 4MIm is substantially high (>14.4) . Thus, 4MIm hardly reacts with CO 2 to form carbamate even in the presence of TEPA.…”