Drug loaded phosphate glass/hydroxyapatite nanocomposite for orthopedic applications

Govindan, R.; Girija, E. K.

doi:10.1039/c4tb00549j

Cited by 34 publications

(23 citation statements)

References 42 publications

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“…All these criteria are well met by CaPs and their composites. In order to make the implant antibacterial, various antibiotics have been incorporated in CaPs [ 510 , 511 , 525 ], for example, gentamicin [ 591 , 592 , 593 , 594 , 595 , 596 ], ibuprofen [ 597 , 598 ], cephalothin [ 593 ], amoxicillin [ 593 ], tobramycin [ 593 ], zoledronate [ 599 ], aspirin [ 600 ], flomoxef sodium [ 601 ], tetracycline [ 602 , 603 ], vancomycin [ 604 , 605 ], streptomycin [ 606 ], etc. Tetracylines have a broad spectrum of antibiotic action and, therefore, are attractive candidates.…”

Section: Antibacterial Calcium Phosphatesmentioning

confidence: 99%

Calcium Phosphate Bioceramics: A Review of Their History, Structure, Properties, Coating Technologies and Biomedical Applications

2017

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Calcium phosphate (CaP) bioceramics are widely used in the field of bone regeneration, both in orthopedics and in dentistry, due to their good biocompatibility, osseointegration and osteoconduction. The aim of this article is to review the history, structure, properties and clinical applications of these materials, whether they are in the form of bone cements, paste, scaffolds, or coatings. Major analytical techniques for characterization of CaPs, in vitro and in vivo tests, and the requirements of the US Food and Drug Administration (FDA) and international standards from CaP coatings on orthopedic and dental endosseous implants, are also summarized, along with the possible effect of sterilization on these materials. CaP coating technologies are summarized, with a focus on electrochemical processes. Theories on the formation of transient precursor phases in biomineralization, the dissolution and reprecipitation as bone of CaPs are discussed. A wide variety of CaPs are presented, from the individual phases to nano-CaP, biphasic and triphasic CaP formulations, composite CaP coatings and cements, functionally graded materials (FGMs), and antibacterial CaPs. We conclude by foreseeing the future of CaPs.

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Section: Antibacterial Calcium Phosphatesmentioning

confidence: 99%

Calcium Phosphate Bioceramics: A Review of Their History, Structure, Properties, Coating Technologies and Biomedical Applications

2017

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“…Furthermore, each from the aforementioned formulations might be covered by a layer of nanodimensional CaPO 4 , as it was done by Zandi et al [ 632 ], who coated a biocomposite of nano-sized rods HA with gelatin by nano-sized HA. Several nanodimensional biocomposites were found to be applicable as carriers for delivery of drugs and growth factors [ 609 , 633 , 634 , 635 ], as well as promising vectors with ultrahigh gene loading and transfection efficiency [ 636 ]. Data are available on the excellent biocompatibility of such biocomposites [ 545 ].…”

Section: Biocomposites and Hybrid Biomaterials Containing Capo mentioning

confidence: 99%

Calcium Orthophosphate-Containing Biocomposites and Hybrid Biomaterials for Biomedical Applications

Dorozhkin¹

2015

JFB

129

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The state-of-the-art on calcium orthophosphate (CaPO4)-containing biocomposites and hybrid biomaterials suitable for biomedical applications is presented. Since these types of biomaterials offer many significant and exciting possibilities for hard tissue regeneration, this subject belongs to a rapidly expanding area of biomedical research. Through the successful combinations of the desired properties of matrix materials with those of fillers (in such systems, CaPO4 might play either role), innovative bone graft biomaterials can be designed. Various types of CaPO4-based biocomposites and hybrid biomaterials those are either already in use or being investigated for biomedical applications are extensively discussed. Many different formulations in terms of the material constituents, fabrication technologies, structural and bioactive properties, as well as both in vitro and in vivo characteristics have been already proposed. Among the others, the nano-structurally controlled biocomposites, those containing nanodimensional compounds, biomimetically fabricated formulations with collagen, chitin and/or gelatin, as well as various functionally graded structures seem to be the most promising candidates for clinical applications. The specific advantages of using CaPO4-based biocomposites and hybrid biomaterials in the selected applications are highlighted. As the way from a laboratory to a hospital is a long one and the prospective biomedical candidates have to meet many different necessities, the critical issues and scientific challenges that require further research and development are also examined.

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“…24 Recently we reported a novel biocompatible, bioactive phosphate glass/ hydroxyapatite (PG/HA) nanocomposite as drug carrier for orthopedic applications. 25 Several polymers such as poly (Llactic) acid (PLLA), 26,27 poly(caprolactone) (PCL), 27 alginate, 27 gelatin, 27,28 and poly-b-hydroxybutyrate 29 have been investigated as possible coating system for bioceramic scaffolds. In general, synthetic polymers exhibit better mechanical strength than natural polymers.…”

Section: Introductionmentioning

confidence: 99%

Polymer coated phosphate glass/hydroxyapatite composite scaffolds for bone tissue engineering applications

2015

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The development of bioactive ceramic composite scaffold materials with enhanced mechanical strength has been a topic of great interest in bone tissue engineering. In the present study, phosphate glass/hydroxyapatite (PG/HA) composite scaffold with an open-porous structure (∼89% porosity and pore size in the range 200−500 µm) has been fabricated by foam replica method. In order to enhance the mechanical strength of this scaffold a polymer coating of alginate, chitosan and gelatin was made on the composite scaffold by immersion method. The polymer coating did not affect the interconnectivity but reduced the porosity of the PG/HA composite scaffold. Biodegradation studies revealed that all the composite scaffolds have undergone significant degradation. But the compressive strength of the gelatin coated scaffold (G-PG/HA) exhibited sevenfold enhancement than the pristine scaffold. The PG/HA and G-PG/HA composite scaffolds revealed excellent biocompatibility with human osteoblast-like MG-63 cells. Hence, G-PG/HA composite scaffold may be a smart promising scaffold for bone tissue engineering.

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Drug loaded phosphate glass/hydroxyapatite nanocomposite for orthopedic applications

Abstract: A cylindrical shaped gentamicin sulfate (GS) loaded phosphate glass/hydroxyapatite (PG/HA) nanocomposite with sustained release behavior has been developed for osteomyelitis.

Cited by 34 publications

References 42 publications

Calcium Phosphate Bioceramics: A Review of Their History, Structure, Properties, Coating Technologies and Biomedical Applications

Calcium Phosphate Bioceramics: A Review of Their History, Structure, Properties, Coating Technologies and Biomedical Applications

Calcium Orthophosphate-Containing Biocomposites and Hybrid Biomaterials for Biomedical Applications

Polymer coated phosphate glass/hydroxyapatite composite scaffolds for bone tissue engineering applications

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