Drug-induced pseudolymphoma and hypersensitivity syndrome. Two different clinical entities

Selected Inflammatory Imitators of Mycosis Fungoides: Histologic Features and Utility of Ancillary Studies

“…Lesions are often associated with a new medication and resolve completely with discontinuation of the offending drug, although that may take several months. [40][41][42] The clinical presentation ranges from a diffuse, maculopapular eruption to papules, plaques, and/or nodules that may be solitary or multiple. [41][42][43][44][45][46] Rare cases of erythroderma have been reported (Figure 4, A and B).…”

“…[40][41][42] The clinical presentation ranges from a diffuse, maculopapular eruption to papules, plaques, and/or nodules that may be solitary or multiple. [41][42][43][44][45][46] Rare cases of erythroderma have been reported (Figure 4, A and B). 42,43,47 Medications that may cause drug-induced pseudolymphoma (DIP) are numerous and include antiepileptic drugs (eg, phenytoin, carbamazepine, sodium valproate), as well as other commonly prescribed medications, such as penicillin, b-blockers, angiotensin-converting enzyme inhibitors, and fluoxetine (as reviewed in Ploysangam et al 43 and Albrecht et al 48 ).…”

“…42,45,47,48 Uncommonly, this syndrome may occur with medications other than anticonvulsants. 42 Pseudolymphoma syndrome generally develops 2 to 8 weeks after initiation of the offending drug and is characterized by a typically widespread, maculopapular eruption; facial edema; fever; lymphadenopathy; arthralgia; peripheral eosinophilia; hepatosplenomegaly; and elevated liver enzymes. 41,42,47 Circulating, atypical lymphocytes may also be identified.…”

“…Typically, patients with DIP experience a complete resolution of their symptoms after cessation of the offending drug, although it may take several months. [40][41][42]48 The mortality rate for patients with pseudolymphoma syndrome/hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms is approximately 10%. 42,47,48 Oral and topic steroids and antihistamines may be required until the process subsides.…”

Effects of Ascaris suum Extract and Sulfamethoxazole on Allergic Airway Inflammation

“…Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome or drug-induced hypersensitivity syndrome (DIHS) is a drug-induced severe adverse reaction characterized by generalized symptoms such as fever, skin eruptions, lymphadenopathy, hepatic dysfunction, and eosinophilia (Callot et al, 1996). Administration of sulfamethoxazole (SMX), a sulfonamide, is associated with a high incidence of hypersensitivity reactions in human (Mandell and Sande, 1990).…”