Drug-induced Pruritus: A Review

Reich, Adam; Ständer, Sonja; Szepietowski, Jacek C.

doi:10.2340/00015555-0650

Cited by 137 publications

(94 citation statements)

References 124 publications

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“…This pruritus may be secondary to a cutaneous drug reaction (e.g., urticaria), but medications can also provoke pruritus without signs of skin irritation (Reich et al 2009). For example, 10-50 % of patients receiving intravenous opioids experience pruritus, as do 20-100 % of patients receiving intraspinal or epidural opioid injections (Ganesh and Maxwell 2007).…”

Section: Pharmacologicmentioning

confidence: 99%

Pruritus Epidemiology and Quality of Life

Leader¹,

Carr²,

Chen³

2015

Handbook of Experimental Pharmacology

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The burden of chronic pruritus is increasingly recognized as significant worldwide. As wet-laboratory researchers investigate the pathophysiology of chronic pruritus, epidemiologists and health services researchers are quantifying the impact of pruritus by incidence, prevalence, and quality of life measures. Outcomes researchers are also investigating factors that may predict chronic pruritus incidence and severity. Such efforts will direct resources for research, public health intervention, and clinical care.

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Section: Pharmacologicmentioning

confidence: 99%

Pruritus Epidemiology and Quality of Life

Leader¹,

Carr²,

Chen³

2015

Handbook of Experimental Pharmacology

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“…Only very rarely do solid tumors cause localized or generalized pruritus. On the other hand, drug-induced pruritus (without rash) is an important differential diagnosis [6], primarily caused by opioids, ACE inhibitors, statins, penicillin, chloroquine, and hydroxyethyl starch infusions.…”

Section: Systemic Disordersmentioning

confidence: 99%

Clinical management of pruritus

Ständer

Zeidler

Magnolo

et al. 2015

J Deutsche Derma Gesell

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SummaryThe care of patients with chronic pruritus as a symptom of a wide variety of underlying diseases continues to confront dermatologists with diagnostic and therapeutic challenges. However, a structured history and a physical examination may already substantially help in narrowing down the number of potential differential diagnoses. Apart form reducing the intensity of pruritus, identification and appropriate treatment of the underlying disease are important needs of patients. If these goals doesn't lead to improvement of itch, current guidelines provide a number of topical and systemic therapies for symptomatic treatment. Various skin lesions (for example, xerosis caused by irritant substances, secondary scratch lesions) prompt patients to consult a dermatologist, but most cases require an interdisciplinary therapeutic approach to identify potential internal medicine, neurologic, or psychosomatic aspects. Although great strides have been made in basic research, specific therapies are still rare, and a precise knowledge of the legal framework for the implementation of guidelines (for example, off-label use) is essential. This CME article gives an overview of the causes of and treatment options for chronic pruritus and discusses both advances in basic research as well as progress in clinical knowledge.

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“…(2)(3)(4) In the cases herein reported, a "toxic" nature might be hypothesized, with accumulation of drugs secondary to many factors: old age and/or possible impairment of liver metabolism and renal excretion, drug interactions due to long-term polytherapy, and reduced water intake. The approach used in our pilot experience might be helpful to assess the iatrogenic origin of chronic pruritus and may be considered throughout the step-by-step diagnostic work-up, at least in selected cases.…”

mentioning

confidence: 99%

“…(2)(3)(4) Drug-induced pruritus is likely to be underestimated in the general population, particularly in elderly subjects. (2,5) We retrospectively reviewed 15 patients, diagnosed with drug-induced pruritus and evaluated during a 3-year period.…”

mentioning

confidence: 99%