Drug-Induced Ectropion

Hegde, Vijay; Robinson, Rosemary; Dean, Fiona; Mulvihill, H.A.; Ahluwalia, Harpreet

doi:10.1016/j.ophtha.2006.09.032

Cited by 30 publications

(13 citation statements)

References 9 publications

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“…There are few reports that address the prevalence of eyelid malpositions in patients treated with intraocular pressure-lowering eyedrops. 3 – 6 , 13 Hegde et al reported a retrospective analysis of 13 patients who were treated with topical medications and presented with topical drug-induced ectropion. 6 Dorzolamide (carbonic anhydrase inhibitor) was the most common offending agent (53%), followed by brimonidine (alpha 2 agonists; 23%).…”

Section: Discussionmentioning

confidence: 99%

“… 3 – 6 , 13 Hegde et al reported a retrospective analysis of 13 patients who were treated with topical medications and presented with topical drug-induced ectropion. 6 Dorzolamide (carbonic anhydrase inhibitor) was the most common offending agent (53%), followed by brimonidine (alpha 2 agonists; 23%). Those authors suggested that the chronic exposure to the causative agent leads to cicatricial changes in the anterior lamella of the eyelid in susceptible individuals and that this can manifest as contact dermatitis leading to tissue edema and mechanical ectropion.…”

Section: Discussionmentioning

confidence: 99%

“…A review of the literature over the past 15 years yielded only three case reports 3 – 5 and one case series 6 of ectropion or entropion purportedly induced by antiglaucoma medications. These reports found a correlation between the usage of antiglaucoma medications and the development of eyelid malposition abnormalities, but there were very few patients to establish the prevalence of the coexistence of these ophthalmologic pathologies.…”

Section: Introductionmentioning

confidence: 99%

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The prevalence of glaucoma in patients undergoing surgery for eyelid entropion or ectropion

Golan¹,

Rabina²,

Kurtz³

et al. 2016

CIA

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Purpose and designThe aim of this study was to establish the prevalence of known glaucoma in patients undergoing ectropion or entropion surgical repair. In this study, retrospective review of case series was performed.ParticipantsAll patients who underwent ectropion or entropion surgery in a tertiary medical center between 2007 and 2014 were included. The etiology of eyelid malpositioning was involutional or cicatricial.MethodsThe medical files of the study participants were reviewed for the presence and type of glaucoma, medical treatment, duration of treatment, and the amount of drops per day. These data were compared to a matched control group of 101 patients who underwent blepharoplasty for dermatochalasis in the same department during the same period.Main outcome measureIn this study, the prevalence of glaucoma in individuals with ectropion or entropion was the main outcome measure.ResultsA total of 227 patients (57% men, mean age: 79.2 years) who underwent ectropion or entropion surgery comprised the study group and 101 patients who underwent upper blepharoplasty for dermatochalasis comprised the control group. Compared to four patients in the control group (4%, P=0.01), 30 of the study patients (13.2%) had coexisting glaucoma. Of 30 glaucomatous patients, 25 had primary open-angle glaucoma for a mean duration of 10.3 years. The glaucomatous patients were treated with an average of 2.7 antiglaucoma medications.ConclusionAn increased prevalence of known glaucoma in patients undergoing ectropion or entropion repair surgery was found. This observation may indicate that the chronic usage of topical anti-glaucoma eyedrops may lead to an increased risk of developing eyelid malpositions, especially in elderly patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The prevalence of glaucoma in patients undergoing surgery for eyelid entropion or ectropion

Golan¹,

Rabina²,

Kurtz³

et al. 2016

CIA

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“…A study of 13 outpatients with topical drug-induced ectropion revealed that 12 were on topical AGMs. Dorzolamide (53%) and brimonidine (23%) were the most common offending agents, whereas other concomitant drugs used were betaxolol, latanoprost, and timolol 9 . Two patients successfully underwent surgical correction for ectropion after discontinuing their topical therapy.…”

Section: Eyelid Malpositionsmentioning

confidence: 99%

“…Clinicians need to be aware of these side effects because studies have shown that such side effects could negatively impact drug adherence and/or compliance 7 . However, these side effects can be reversed by discontinuing the offending drug and changing to another class of drug, using preservative-free formulations, or switching to laser or surgical treatments, if detected early 8–10 . This review summarizes the current knowledge about eyelid changes that develop secondary to chronic AGM use, excluding the effects on the ocular surface.…”

Section: Introductionmentioning

confidence: 99%

Ocular Adnexal Changes After Antiglaucoma Medication Use

Adewara¹,

Singh²

2023

International Ophthalmology Clinics

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Current awareness: Pharmacoepidemiology and drug safety

2007

Pharmacoepidemiology and Drug

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of pharmacoepidemiology and drug safety. Each bibliography is divided into 20 sections: 1 Reviews; 2 General; 3 Anti‐infective Agents; 4 Cardiovascular System Agents; 5 CNS Depressive Agents; 6 Non‐steroidal Anti‐inflammatory Agents; 7 CNS Agents; 8 Anti‐neoplastic Agents; 9 Haematological Agents; 10 Neuroregulator‐Blocking Agents; 11 Dermatological Agents; 12 Immunosuppressive Agents; 13 Autonomic Agents; 14 Respiratory System Agents; 15 Neuromuscular Agents; 16 Reproductive System Agents; 17 Gastrointestinal System Agents; 18 Anti‐inflammatory Agents ‐ Steroidal; 19 Teratogens/fetal exposure; 20 Others. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted.

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Drug-Induced Ectropion

Cited by 30 publications

References 9 publications

The prevalence of glaucoma in patients undergoing surgery for eyelid entropion or ectropion

The prevalence of glaucoma in patients undergoing surgery for eyelid entropion or ectropion

Ocular Adnexal Changes After Antiglaucoma Medication Use

Current awareness: Pharmacoepidemiology and drug safety

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