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“…For example, infusion of dopamine into dogs during a 14 day subacute toxicity study resulted in the formation of myocardial lesions (FDA, 1973). Several experts have also noted that the lesions appear different in their histological appearance, time-course, and severity than those seen after infusion of other cardiotoxic drugs, such as Adriamycin (Buja et al, 1973(Buja et al, , 1974a. Several experts have also noted that the lesions appear different in their histological appearance, time-course, and severity than those seen after infusion of other cardiotoxic drugs, such as Adriamycin (Buja et al, 1973(Buja et al, , 1974a.…”
Section: Review Of Hemoglobin-induced Myocardial Lesions 369mentioning
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“…For example, infusion of dopamine into dogs during a 14 day subacute toxicity study resulted in the formation of myocardial lesions (FDA, 1973). Several experts have also noted that the lesions appear different in their histological appearance, time-course, and severity than those seen after infusion of other cardiotoxic drugs, such as Adriamycin (Buja et al, 1973(Buja et al, , 1974a. Several experts have also noted that the lesions appear different in their histological appearance, time-course, and severity than those seen after infusion of other cardiotoxic drugs, such as Adriamycin (Buja et al, 1973(Buja et al, , 1974a.…”
Section: Review Of Hemoglobin-induced Myocardial Lesions 369mentioning
“…Catecholamine induced myocardial damage progresses as the demand of oxygen increases with increased metabolic rate by stimulation of catecholamine receptors and a mismatch occurs in myocardial perfusion [ 3 ]. Anthracyclines like daunorubicin and adriamycin can cause similar acute myocardial damage and delayed response to cumulative effects of these drugs results in interstitial fibrosis and myocardial degeneration [ 4 ].…”
Section: Discussionmentioning
“…Cardiac toxicity is a well-recognized complication of doxorubicin and daunorubicin and is frequently the dose-limiting factor in their administration (157)(158)(159). Clinical toxicity is usually manifested by evidence of impaired left ventricular systolic function.…”
Section: Anthracycline Chemotherapy (Doxorubicin and Daunorubicin)mentioning