Drug eruptions from mesna. After cyclophosphamide treatment of patients with systemic lupus erythematosus and dermatomyositis

Zonzits, E.

doi:10.1001/archderm.128.1.80

Cited by 9 publications

(9 citation statements)

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“…Although prick tests were done in patients with FDE [22], this diagnostic tool should be used to exclude underlying allergic type-I reactions (urticaria) and can be omitted in clear-cut FDE cases. As expected, in the presented case the prick test was negative.…”

Section: Discussionmentioning

confidence: 99%

Fixed drug eruption induced by an iodinated non-ionic X-ray contrast medium: a practical approach to identify the causative agent and to prevent its recurrence

Böhm

Medina²,

Prieto³

et al. 2006

Eur Radiol

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We describe the case of a 61-year-old physician who developed a fixed drug eruption (FDE) after i.v. administration of a non-ionic monomeric iodinated X-ray contrast medium (CM) (iopromide). During CM injection, a sensation of heat occurred, which was most intense in the right inguinal region. Four hours later, the FDE arose with a red macule of approximately 2 cm in diameter covering a dermal infiltration in the right inguinal region, and enlarged up to a final size of 15 x 8 cm, accompanied by a burning sensation. The patient's history revealed a similar reaction in the same localization and of the same clinical appearance after CM injection 1 year before. Patch testing 4 months later revealed positive reactions to iomeprol and iohexol. Iopamidol injection for another CT examination 23 months later was well tolerated. Based on these results, we suggest patch testing after CM-induced FDE, which could help to select a CM for future CT examinations. Late onset of adverse CM reactions may manifest as FDE. Patch testing within the previous skin reaction area is the diagnostic tool that should be used to confirm the suspected agent, possible cross-reacting agents and well-tolerated agents.

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Section: Discussionmentioning

confidence: 99%

Fixed drug eruption induced by an iodinated non-ionic X-ray contrast medium: a practical approach to identify the causative agent and to prevent its recurrence

Böhm

Medina²,

Prieto³

et al. 2006

Eur Radiol

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“…The rash recurred in the one patient rechallenged with mesna. Finally, Zonzits et al report drug eruptions in six patients with systemic lupus erythematosis, and one with dermatomyositis receiving monthly pulses of cyclophosphamide and mesna 6. Again, all the patients in this series had positive reactions to prick and intradermal tests with undiluted mesna only.…”

Section: Discussionmentioning

confidence: 62%

Adverse hypersensitivity reactions to mesna as adjunctive therapy for cyclophosphamide

Khaw

Downie

Waters

et al. 2005

Pediatric Blood & Cancer

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“…En effet, seuls cinq cas d'érythème pigmenté fixe au mesna sont rapportés : deux chez des patientes lupiques [2], un chez un patient présentant une sclérodermie [3] et deux pour une sclérose en plaque [4,5]. Seuls deux cas sont rapportés au Japon pour le cyclophosphamide [6], sans prise de mesna associé.…”

Section: Discussionunclassified

Tests épicutanés pour un érythème pigmenté fixe après prise de cyclophosphamide associé au mesna

Delaigue

Boyé

Pasquine

et al. 2015

Annales de Dermatologie et de Vénéréologie

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Drug eruptions from mesna. After cyclophosphamide treatment of patients with systemic lupus erythematosus and dermatomyositis

Cited by 9 publications

References 0 publications

Fixed drug eruption induced by an iodinated non-ionic X-ray contrast medium: a practical approach to identify the causative agent and to prevent its recurrence

Fixed drug eruption induced by an iodinated non-ionic X-ray contrast medium: a practical approach to identify the causative agent and to prevent its recurrence

Adverse hypersensitivity reactions to mesna as adjunctive therapy for cyclophosphamide

Tests épicutanés pour un érythème pigmenté fixe après prise de cyclophosphamide associé au mesna

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