Drug Eruptions From Anticonvulsant Drugs

Pseudolymphoma Syndrome

“…The clinical picture of pseudolymphoma consists of generalized lymphadenopathy, malaise, fever and a skin rash, with the frequent association of pain and swelling in the joints as well as hepatosplenomegaly [1,2,[5][6][7][8][9]. In some cases diarrhea may be a part of this picture [10,11].…”

Implications of Endogenous Retroelements in the Etiopathogenesis of Systemic Lupus Erythematosus

“…Increased L1 transcripts and ORF1p protein have been detected in kidney biopsies from patients with lupus nephritis and in salivary gland biopsies from Sjögren's syndrome patients [98]. In healthy individuals, L1 transcripts are low or undetectable, but can be induced by demethylating drugs like 5-aza-deoxycytosine [99], including those known to cause drug-induced lupus [100,101], e.g., hydralazine and Alu elements have also gained interest in lupus research due to the association of Aluderived RNA with Ro60 [95][96][97], a well-recognized SLE autoantigen. In a 2015 paper [97], immune complexes formed by anti-Ro60 autoantibodies where isolated from SLE patients and the bound RNA sequenced, revealing that much of it was Alu-and L1-derived.…”

“…Increased L1 transcripts and ORF1p protein have been detected in kidney biopsies from patients with lupus nephritis and in salivary gland biopsies from Sjögren's syndrome patients [98]. In healthy individuals, L1 transcripts are low or undetectable, but can be induced by demethylating drugs like 5-aza-deoxycytosine [99], including those known to cause drug-induced lupus [100,101], e.g., hydralazine and procainamide. Reduced methylation of the 5 regulatory ("promoter") region of L1 has been reported in both adult and pediatric lupus patients [102].…”

Hautnebenwirkungen interner Arzneimittel

“…Wegen der weitverbreiteten An wendung von Hydantoinen und Phénobarbital ist ein Fall von Kreuzsen sibilisierung zwischen diesen beiden Mitteln erwähnenswert [173], Die Häufigkeitsangaben für die bekannte Gingivahyperplasie unter Hydantointherapie schwanken zwischen 20 und 60% (cf. Tabelle, Diverses 6.2).…”