Drug Delivery with PEGylated MoS₂ Nano‐sheets for Combined Photothermal and Chemotherapy of Cancer

Abstract

MoS2 nanosheets functionalized with poly-ethylene glycol are for the first time used as a multifunctional drug delivery system with high drug loading capacities. Using doxorubicin as the model drug and taking advantages of the strong near-infrared absorbance of MoS2, combined photothermal and chemotherapy of cancer is realized in animal experiments, achieving excellent synergistic anti-tumor effect upon systemic administration.

Molybdenum disulfide/graphene oxide nanocomposites show favorable lung targeting and enhanced drug loading/tumor-killing efficacy with improved biocompatibility

“…Figure 1a shows the morphologies and structures of all materials, as characterized by TEM. Consistent with previous observations, 28,42 bulk MoS 2 materials were not well dispersed in aquatic solutions and formed agglomerates, as evidenced by the TEM images (Figure 1a). By contrast, GO exhibited a single-layer sheet-like structure, while MoS 2 /GO composites, Lys-MoS 2 and FA-MoS 2 all appeared in a few-layer sheet-like structure without agglomeration (Figure 1a).…”

“…The thermal gravimetric analysis unveiled that the component ratio for MoS 2 and GO was 42 vs 58% within the MoS 2 /GO composites (Supplementary Figure S2). Pristine MoS 2 materials are poorly dispersible and tend to dramatically aggregate in water and physiological solutions, 26,28,29 which prevents the biomedical applications. Lys and FA are two main types of small molecules with excellent biocompatibility and are often used to modify nanomaterials.…”

“…26,27 Despite recent progresses, there are still considerable scientific and technical challenges for MoS 2 nanomaterials in biomedical applications. For example, pristine MoS 2 materials are poorly dispersible in aqueous solutions, 28,29 which greatly restrains their bioapplications. Meanwhile, more work needs to be done to achieve diversified functionalization and selective targeting together with optimal biocompatibility.…”

“…In the meantime, given the poor dispersity of bulk MoS 2 and the inability to target specific tissue sites, more improvement therefore becomes very necessary for its biological applications, especially for targeted cancer nanotheranostics. 28,32 In contrast, GO is highly soluble in aqueous solutions with a pronounced ability to target the lung. 9,10,21 Emerging evidence reports the applications of MoS 2 /GO nanocomposites in bioscience.…”

A 3D-printed scaffold with MoS2 nanosheets for tumor therapy and tissue regeneration

“…In addition, previous studies have demonstrated that MoS 2 nanosheets possessed excellent photothermal therapeutic effects on tumors both in vitro and in vivo. [15][16][17][18] However, these studies primarily focused on simple tumor therapy using MoS 2 in the form of particles, which limits their application. Specifically, MoS 2 particles lack the desired mechanical strength and porous structure to induce bone regeneration after the surgical resection of tumor tissues and repair large tumor-induced bone defects.…”