Drug delivery system based on poly(ether‐block‐amide) and acrylic acid for controlled release of vancomycin

Ortega, Alejandra; Meléndez‐Ortiz, H. Iván; García-Uriostegui, Lorena; Ávila-Soria, Griselda

doi:10.1002/app.45745

Cited by 6 publications

(3 citation statements)

References 28 publications

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“…The current study has evaluated SBB binding and release from four different matrices. A potential candidate should be able to promote a sustained drug release for at least 8 hr 50 and all evaluated matrices displayed SBB release for this time period. In addition, the development of a TDDS system involves the optimization of drug permeation through the skin over a period of 3 days and such studies will be conducted in future work for the matrices evaluated here to gain information about the relationship between the SBB release rate and skin permeation.…”

Section: Results and Discusionmentioning

confidence: 99%

Evaluation of acrylic acid grafting on the loading and release of scopolamine butylbromide from polymeric matrices for future sialorrhea treatment

Morise

Mutch

Garms

et al. 2020

J of Applied Polymer Sci

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Sialorrhea is a disorder which causes an increase in salivation. Scopolamine butylbromide (SBB) can be administrated to treat sialorrhea and its transdermal application minimizes the occurrence of side effects. This work compared SBB adsorption and release from two polymer matrices, polycaprolactone and natural rubber latex, as well as the matrices modified by gamma irradiation-induced graft copolymerization of acrylic acid (AAc). Grafting with AAc-introduced carboxylate groups onto the surface of the matrices evident from chemical analysis and resulted in increased hydrophilicity evident from contact angle measurements. SBB adsorbed to the matrices without changing its structure and for the AAc-grafted matrices this was governed by electrostatic interactions. Higher SBB loading was observed for the AAc-grafted matrices while SBB release was slower for the nongrafted matrices than the grafted matrices. The four different matrices produced are candidates for the development of a transdermal drug delivery system.

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Section: Results and Discusionmentioning

confidence: 99%

Evaluation of acrylic acid grafting on the loading and release of scopolamine butylbromide from polymeric matrices for future sialorrhea treatment

Morise

Mutch

Garms

et al. 2020

J of Applied Polymer Sci

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“…These structures are used to make nanoparticles for drug formulations such as nanodrug delivery system. Indeed, polymers have an important place in the elaboration of nanovectors aimed to protect, carry on, and release the encapsulated drug in the pathological site (via stimulus such as thermal response, pH sensitivity, light, or ionic strength). − The most common polymers used are cellulose derivatives, poly( N -vinylpyrrolidone) (PVP), poloxamers, acrylic derivatives, polyols, poly( l -lysine) (PLL), poly(ethylenimine) (PEI), poly(lactic- co -glycolic acid) (PLGA), , and poly(ethylene glycol) (PEG) . PEG is the most widely used hydrophilic polymer in medical applications because of its interesting properties.…”

Section: Introductionmentioning

confidence: 99%

Amphiphilic Heterograft Copolymers Bearing Biocompatible/Biodegradable Grafts

Glaive,

Cœur,

Guigner

et al. 2024

Langmuir

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The amphiphilic heterograft copolymers bearing biocompatible/biodegradable grafts [poly(2-methyl-2-oxazoline-co-2-pentyl-2-oxazoline)-g-poly(d-l-lactic acid)/poly(2-ethyl-2-oxazoline)] were synthesized successfully by the combination of cationic ring-opening polymerization and click chemistry via the ⟨“grafting to”⟩ approach. The challenge of this synthesis was to graft together hydrophobic and hydrophilic chains on a hydrophilic platform based on PMeOx. The efficiency of grafting depends on the chemical nature of the grafts and of the length of the macromolecular chains. The self-assembly of these polymers in aqueous media was investigated by DLS, cryo-TEM, and SANS. The results demonstrated that different morphologies were obtained from nanospheres and vesicles to filaments depending on the hydrophilic weight ratio in the heterograft copolymer varying from 0.38 until 0.84. As poly(2-ethyl-2-oxazoline) is known to be thermoresponsive, the influence of temperature rise on the nanoassembly stability was studied in water and in a physiological medium. SANS and DLS measurements during a temperature ramp allowed to show that nanoassemblies start to self-assemble in “raspberry like” primary structures at 50 °C, and these structures grow and get denser as the temperature is increased further. These amphiphilic heterograft copolymers may include hydrophobic drugs and should find important applications for biomedical applications which require stealth properties.

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“…Cylindrical brushes with polyether side chains 7 are one of the most investigated systems for delivery of biologically active substances like indomethacin 8,9 or doxorubicin 10,11 . Other examples have been reported for grafted copolymers with biodegradable polyester side chains 12,13 , or pH-sensitive weak polyelectrolyte side chains like poly((meth)acrylic acid) 14–16 , polyvinylpyridine 17 and polyethyleneimine 18,19 . The brushes based on biopolymer backbone, like chitosan 20 , or protein 21 were also applied as drug carriers 22,23 .…”

Section: Introductionmentioning

confidence: 99%

Choline supported poly(ionic liquid) graft copolymers as novel delivery systems of anionic pharmaceuticals for anti-inflammatory and anti-coagulant therapy

Bielas

Mielańczyk

Skonieczna

et al. 2019

Sci Rep

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New type of carriers based on grafted poly(ionic liquid)s was designed for delivery of ionically attached salicylates (Sal). Choline derived ionic liquid monomeric units were successfully introduced with various content in the side chains by the controlled radical polymerization. Properly high amounts of ionic pharmaceutics in the polymer systems were achieved by the well-fitted length and grafting degree of the side chains. In aqueous solution the graft copolymers were self-assembled into the spherical superstructures with sizes up to 73 nm. Delivery studies showed “burst” release within 4 h, after that it was slower yielding ~70% of released drug within 80 h. Proposed nanocarriers supported low toxicity against human cells (NHDF and BEAS-2B), anti-inflammation activity evaluated with the use of pro-inflammatory interleukins (IL-6 and IL-8) and antibacterial activities towards E. coli. Adjustment of ionic drug content by structural parameters of graft copolymers, including grafting degree and graft length, are advantageous to tailor nanocarriers with self-assembly properties in aqueous media. Effective release process by ionic exchange and biological activity with low toxicity are promising for further development of this type of drug delivery (DDS).

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Drug delivery system based on poly(ether‐block‐amide) and acrylic acid for controlled release of vancomycin

Cited by 6 publications

References 28 publications

Evaluation of acrylic acid grafting on the loading and release of scopolamine butylbromide from polymeric matrices for future sialorrhea treatment

Evaluation of acrylic acid grafting on the loading and release of scopolamine butylbromide from polymeric matrices for future sialorrhea treatment

Amphiphilic Heterograft Copolymers Bearing Biocompatible/Biodegradable Grafts

Choline supported poly(ionic liquid) graft copolymers as novel delivery systems of anionic pharmaceuticals for anti-inflammatory and anti-coagulant therapy

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