Drug-associated hyperpigmentation of the oral mucosa: report of four cases

Tosios, Konstantinos I.; Kalogirou, Eleni‐Marina; Sklavounou, Alexandra

doi:10.1016/j.oooo.2017.10.006

Cited by 34 publications

(41 citation statements)

References 56 publications

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“…Pigmented lesions of the oral cavity consist of a heterogeneous group with several etiopathogeneses, from reactional to neoplastic processes. Moreover, some oral pigmentations are associated with systemic conditions (Eisen, ; Gondak, da Silva‐Jorge, Jorge, Lopes, & Vargas, ; Hassona, Sawair, Al‐Karadsheh, & Scully, ; Hatch, ; Kauzman, Pavone, Blanas, & Bradley, ; Lenane & Powell, ; Meleti, Vescovi, Mooi, & van der Waal, ; Tosios, Kalogirou, & Sklavounou, ). Oral pigmentations have either a melanocytic or a nonmelanocytic origin.…”

Section: Introductionmentioning

confidence: 99%

Pigmented lesions of the oral mucosa: A cross‐sectional study of 458 histopathological specimens

et al. 2018

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Section: Introductionmentioning

confidence: 99%

Pigmented lesions of the oral mucosa: A cross‐sectional study of 458 histopathological specimens

et al. 2018

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“…The literature reported that prolonged systemic administration of this drug can determine the deposition of hemosiderin in the tissues of the oral cavity. Chloroquine chelates iron and/or melanin; moreover, melanocytes are stimulated in melanin production [2,3].…”

Section: Discussionmentioning

confidence: 99%

Hard Palate Hyperpigmentation Induced by Chloroquine: A Case Report

Attuati

Martini

Bonacina

et al. 2019

The XV National and III International Congress of the Italian Society of Oral Pathology and Medicine

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“…In total, 22 cases (91.7%) were associated with minocycline used for facial acne vulgaris at a dosage of 100-200 mg daily. 4,12,13,15,17,18,23,[27][28][29][30]34,37,44,65 The overall treatment duration ranged from 2 weeks to 11 years. Clinical characteristics included a bluish to grayish discoloration with…”

Section: Study Characteristics and Outcomesmentioning

confidence: 99%

“…38,64 Antimalarial medications were linked to MIOH in 68 cases affecting the palate, gingiva, and lips. Quinacrine hydrochloride, 47,63,66 hydroxychloroquine, 18,39 quinidine sulfate, 35,41 Daraclor, 32 amodiaquine, 42 and chloroquine compound 31,33,39,45,60 were the most commonly-reported offending medications. Oral melanosis occurred with different doses, in various populations, within fluctuating periods.…”

Section: Dovepressmentioning

confidence: 99%

“…Oral hyperpigmentation induced by chemotherapeutic and antineoplastic agents was reported in 30 and 125 patients, respectively. The most prevalent agent was imatinib 18,21,22,24,36,46,[48][49][50][51][52][53][54][55]57,62 other agents included capecitabine, 16 cyclophosphamide, 25,40 5-fluorouracil, 43 irinotecan, 26 and hydroxyurea. 11 The risk of oral pigmentation in association with imatinib therapy increased as the duration of intake increased (an average of 7 years) and occurred most commonly in the hard palate.…”

Section: Dovepressmentioning

confidence: 99%

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<p>Medication-Induced Oral Hyperpigmentation: A Systematic Review</p>

Binmadi¹,

Bawazir²,

Alhindi³

et al. 2020

PPA

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Background: Medication-induced oral hyperpigmentation is an oral condition that impacts patients' quality of life and has been linked to many systemic therapeutic agents. The exact pathogenesis of tissue pigmentation varies greatly and is not completely known. This systematic review aimed to present data on the causal association between medications and the development of oral/mucosal pigmentation as an adverse drug reaction. Methods: A systematic review and analysis of literature were conducted using the following databases: PubMed, Science Direct, ProQuest, Web of Science, and Scopus. The systematic review included original articles written in English and published between January 1982 and June 2020. Following the PRISMA statement, eligible articles were systematically reviewed, and data were extracted from eligible studies and analyzed. Results: A total of 235 articles were identified, of which 57 met the inclusion criteria and were included in this review. The mean age of included patients was 46.2±16.38 years (range: 10-90 years) with a male to female ratio of 1:1.45. Oral mucosal hyperpigmentation was reported following the use of several classes of medications such as antiviral (eg, zidovudine), antibiotic (eg, minocycline), antimalarial (eg, chloroquine), anti-fungal (eg, ketoconazole), antileprotic (eg, clofazimine), antihypertensive (eg, amlodipine), chemotherapeutic, and antineoplastic drugs. The risk of developing oral pigmentation was significantly higher with antimalarial medications, antibiotics, antineoplastic and chemotherapeutic agents. Medication-induced oral hyperpigmentation was most frequent among women and in the hard palate. Conclusion: Future research is warranted to better understand the pathogenesis and risk factors for medication-induced oral hyperpigmentation in order to reassure patients during prescription and management.

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Drug-associated hyperpigmentation of the oral mucosa: report of four cases

Cited by 34 publications

References 56 publications

Pigmented lesions of the oral mucosa: A cross‐sectional study of 458 histopathological specimens

Pigmented lesions of the oral mucosa: A cross‐sectional study of 458 histopathological specimens

Hard Palate Hyperpigmentation Induced by Chloroquine: A Case Report

<p>Medication-Induced Oral Hyperpigmentation: A Systematic Review</p>

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