Shunyi Zhu, Bin Gao, Meichun Deng, Yuzhe Yuan, Lan Luo, Steve Peigneur, Yucheng Xiao, Songping Liang, Jan Tytgat
Abstract:The design of animal toxins with high target selectivity has long been a goal in protein engineering. Based on evolutionary relationship between the Drosophila antifungal defensin (drosomycin) and scorpion depressant Na(+) channel toxins, we exploited a strategy to create a novel chimeric molecule (named drosotoxin) with high selectivity for channel subtypes, which was achieved by using drosomycin to substitute the structural core of BmKITc, a depressant toxin acting on both insect and mammalian Na(+) channels…
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