Drosophila Pax-6/eyeless is essential for normal adult brain structure and function

Mutational analysis of the eyeless gene and phenotypic rescue reveal that an intact Eyeless protein is necessary for normal eye and brain development in Drosophila

“…Phenotypes were most severe in ey OK107/4 and ey OK107/16 , while the phenotypes observed in ey OK107/10 flies were the mildest of the ey OK107/X alleles. Eye and brain development was not significantly affected in either ey OK107/4 /ey 2 , ey OK107/6 /ey 2 , and ey OK107/10 /ey 2 animals, similar to previous observations for ey JD /ey 2 and ey D1Da /ey 2 (Callaerts et al, 2001). However, the ey OK107/16 /ey 2 combination exhibited a moderate eye phenotype.…”

Mutational analysis of the eyeless gene and phenotypic rescue reveal that an intact Eyeless protein is necessary for normal eye and brain development in Drosophila

“…Phenotypes were most severe in ey OK107/4 and ey OK107/16 , while the phenotypes observed in ey OK107/10 flies were the mildest of the ey OK107/X alleles. Eye and brain development was not significantly affected in either ey OK107/4 /ey 2 , ey OK107/6 /ey 2 , and ey OK107/10 /ey 2 animals, similar to previous observations for ey JD /ey 2 and ey D1Da /ey 2 (Callaerts et al, 2001). However, the ey OK107/16 /ey 2 combination exhibited a moderate eye phenotype.…”

Drosophila CtBP regulates proliferation and differentiation of eye precursors and complexes with Eyeless, Dachshund, Dan, and Danr during eye and antennal development

“…A ~115 kD protein and a ~130 kD protein were detected by anti-Ey and anti-Dac antibodies, respectively, only in immunoprecipitates obtained with anti-Dan, but not in immunoprecipitates obtained with anti-Tubulin. These apparent molecular weights have previously been reported for Ey (Callaerts et al, 2001; Punzo et al, 2001) and for Dac (Chen et al, 1997). …”

Visual Targeting of Motor Actions in Climbing Drosophila

“…In accordance with earlier findings on step-length control in bridge-defective flies [3,14,15] and described projection systems [5], we propose a structure-function model of the protocerebral bridge. The two-times-eight glomeruli of the bridge are connected by the horizontal fiber system to the one-timeseight fans of the fan-shaped body in a crossover scheme (Figures 4B and 4C).…”

Mutational analysis of the eyeless gene and phenotypic rescue reveal that an intact Eyeless protein is necessary for normal eye and brain development in Drosophila

“…Phenotypes were most severe in ey OK107/4 and ey OK107/16 , while the phenotypes observed in ey OK107/10 flies were the mildest of the ey OK107/X alleles. Eye and brain development was not significantly affected in either ey OK107/4 /ey 2 , ey OK107/6 /ey 2 , and ey OK107/10 /ey 2 animals, similar to previous observations for ey JD /ey 2 and ey D1Da /ey 2 (Callaerts et al, 2001). However, the ey OK107/16 /ey 2 combination exhibited a moderate eye phenotype.…”

Drosophila CtBP regulates proliferation and differentiation of eye precursors and complexes with Eyeless, Dachshund, Dan, and Danr during eye and antennal development

“…A ~115 kD protein and a ~130 kD protein were detected by anti-Ey and anti-Dac antibodies, respectively, only in immunoprecipitates obtained with anti-Dan, but not in immunoprecipitates obtained with anti-Tubulin. These apparent molecular weights have previously been reported for Ey (Callaerts et al, 2001; Punzo et al, 2001) and for Dac (Chen et al, 1997). …”

Visual Targeting of Motor Actions in Climbing Drosophila

“…In accordance with earlier findings on step-length control in bridge-defective flies [3,14,15] and described projection systems [5], we propose a structure-function model of the protocerebral bridge. The two-times-eight glomeruli of the bridge are connected by the horizontal fiber system to the one-timeseight fans of the fan-shaped body in a crossover scheme (Figures 4B and 4C).…”

Mutational analysis of the eyeless gene and phenotypic rescue reveal that an intact Eyeless protein is necessary for normal eye and brain development in Drosophila

“…Phenotypes were most severe in ey OK107/4 and ey OK107/16 , while the phenotypes observed in ey OK107/10 flies were the mildest of the ey OK107/X alleles. Eye and brain development was not significantly affected in either ey OK107/4 /ey 2 , ey OK107/6 /ey 2 , and ey OK107/10 /ey 2 animals, similar to previous observations for ey JD /ey 2 and ey D1Da /ey 2 (Callaerts et al, 2001). However, the ey OK107/16 /ey 2 combination exhibited a moderate eye phenotype.…”

Drosophila CtBP regulates proliferation and differentiation of eye precursors and complexes with Eyeless, Dachshund, Dan, and Danr during eye and antennal development

“…A ~115 kD protein and a ~130 kD protein were detected by anti-Ey and anti-Dac antibodies, respectively, only in immunoprecipitates obtained with anti-Dan, but not in immunoprecipitates obtained with anti-Tubulin. These apparent molecular weights have previously been reported for Ey (Callaerts et al, 2001; Punzo et al, 2001) and for Dac (Chen et al, 1997). …”

Visual Targeting of Motor Actions in Climbing Drosophila

“…In accordance with earlier findings on step-length control in bridge-defective flies [3,14,15] and described projection systems [5], we propose a structure-function model of the protocerebral bridge. The two-times-eight glomeruli of the bridge are connected by the horizontal fiber system to the one-timeseight fans of the fan-shaped body in a crossover scheme (Figures 4B and 4C).…”