Journal of Cell Biology volume 217, issue 3, P1033-1045 2018 DOI: 10.1083/jcb.201705104 View full text
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Giorgos Tsoumpekos, Linda Nemetschke, Elisabeth Knust

Abstract: How signaling and scaffolding proteins are coordinated apically to control junctional tension and hence epithelial cell growth is unclear. Tsoumpekos et al. identify the Drosophila scaffolding protein Big bang as a novel regulator of growth in epithelial cells of the wing disc by showing that big bang ensures proper junctional tension and apical cytocortex organization.