Reducing cropland ammonia (NH3) emissions while improving air quality and food supply is a challenge, particularly in China where there are millions of smallholder farmers. We tested the effectiveness of a tailored nitrogen (N) management strategy applied to wheat-maize cropping systems in "Demonstration Squares" across Quzhou county in the North China Plain. The N management techniques included optimal N rates, deep fertilizer placement and application of urease inhibitors, implemented through cooperation between government, researchers, businesses and smallholders.Compared with conventional local smallholder practice, our NH3 mitigation campaign reduced NH3 volatilization from wheat and maize by 49% and 39%, and increased N use efficiency by 28% and 40% and farmers' profitability by 25% and 19%, respectively, with no detriment to crop yields. County-wide atmospheric NH3 and PM2.5 concentrations decreased by 40% and 8%, respectively. County-wide net benefits were estimated at $7.0 million. Our "Demonstration Square" approach shows that cropland NH3 mitigation and improved air quality and farm profitability can be achieved simultaneously by coordinated actions at the county level. Ammonia (NH3) is a major alkaline atmospheric gas that plays an important role in the nitrogen (N) cycle and other atmospheric chemical processes 1 . China is the global hotspot of cropland NH3 emissions 2 . The country accounts for >30% of global N fertilizer consumption, but the N use efficiency (NUE) is only 40% for major food crops such as maize and wheat 3 . Due to the low NUE, N losses to air and water are high and consequently total annual NH3 emission in China account for approximately 34% of the global emissions 4 . Excessive NH3 emissions promote the formation of PM2.5 (fine particles of aerodynamic diameters <2.5 μm) 5 and are estimated to contribute 8-11% of PM2.5 concentrations in the most developed regions of China with consequent adverse impacts on human heath 6,7 , while enhanced NH3 deposition is a threat to the biodiversity of terrestrial ecosystems. Reducing NH3 emissions via increasing NUE is