Journal of Cell Biology volume 217, issue 10, P3683-3697 2018 DOI: 10.1083/jcb.201709149 View full text
Erica J. Hutchins, Marianne E. Bronner

Abstract: Neural crest cells undergo a spatiotemporally regulated epithelial-to-mesenchymal transition (EMT) that proceeds head to tailward to exit from the neural tube. In this study, we show that the secreted molecule Draxin is expressed in a transient rostrocaudal wave that mirrors this emigration pattern, initiating after neural crest specification and being down-regulated just before delamination. Functional experiments reveal that Draxin regulates the timing of cranial neural crest EMT by transiently inhibiting ca…

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